DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment sty and Notch2

DIOPT Version :9

Sequence 1:	NP_523902.2	Gene:	sty / 38424	FlyBaseID:	FBgn0014388	Length:	589	Species:	Drosophila melanogaster
Sequence 2:	NP_035058.2	Gene:	Notch2 / 18129	MGIID:	97364	Length:	2473	Species:	Mus musculus

Alignment Length:	144	Identity:	34/144 - (23%)
Similarity:	46/144 - (31%)	Gaps:	57/144 - (39%)

- Green bases have known domain annotations that are detailed below.

  Fly   379 PRC----GRCRCEQCQSPRPLPQTWVCNKTCLCSAESVIDYASCLCCAKALFYHCARDNDLDCDD 439
            |||    ..|..:.||:          :.|||    ..|...:|||.......||    :|:.::
Mouse   451 PRCEMDINECHSDPCQN----------DATCL----DKIGGFTCLCMPGFKGVHC----ELEVNE 497

  Fly   440 GNGTPCVDN----------PCSCGPYKRTQRWGWLGALSIF-------LPCLWFYWPMRGCMKLC 487
            ....|||:|          .|.|.|       |:.|.:...       .|||      .|.
Mouse   498 CQSNPCVNNGQCVDKVNRFQCLCPP-------GFTGPVCQIDIDDCSSTPCL------NGA---- 545

  Fly   488 EKCYGRFAGRGCRC 501
             ||.....|..|:|
Mouse   546 -KCIDHPNGYECQC 558

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sty	NP_523902.2	Sprouty	384..488	CDD:282994	26/120 (22%)
Notch2	NP_035058.2	EGF_CA	109..143	CDD:238011
		EGF_CA	182..218	CDD:238011
		EGF_CA	260..296	CDD:238011
		EGF_CA	298..335	CDD:238011
		EGF_CA	415..454	CDD:238011	2/2 (100%)
		EGF_CA	456..492	CDD:238011	12/53 (23%)
		EGF_CA	495..530	CDD:238011	9/41 (22%)
		EGF_CA	532..567	CDD:238011	9/38 (24%)
		EGF_CA	570..604	CDD:238011
		EGF_CA	608..643	CDD:238011
		EGF_CA	645..679	CDD:238011
		EGF_CA	682..717	CDD:238011
		EGF_CA	757..793	CDD:238011
		EGF_CA	795..831	CDD:238011
		EGF_CA	873..909	CDD:238011
		EGF_CA	911..947	CDD:238011
		EGF_CA	949..985	CDD:238011
		EGF_CA	987..1022	CDD:238011
		EGF_CA	1025..1061	CDD:238011
		EGF_CA	1117..1147	CDD:238011
		EGF_CA	1151..1185	CDD:238011
		EGF_CA	1188..1223	CDD:238011
		EGF_CA	1225..1262	CDD:238011
		EGF_CA	1264..1302	CDD:238011
		EGF_CA	<1312..1343	CDD:238011
		Notch	1423..1456	CDD:333809
		Negative regulatory region (NRR). /evidence=ECO:0000250	1425..1679
		NL	1459..1496	CDD:197463
		Notch	1501..1534	CDD:333809
		NOD	1540..1591	CDD:311024
		NODP	1621..1675	CDD:311559
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1755..1778
		ANKYR	<1820..1932	CDD:223738
		ANK repeat	1828..1875	CDD:293786
		ANK 1	1828..1872
		ANK 2	1877..1906
		ANK repeat	1878..1908	CDD:293786
		ANKYR	1880..2067	CDD:223738
		ANK 3	1910..1940
		ANK repeat	1944..1975	CDD:293786
		ANK 4	1944..1973
		Ank_2	1949..2041	CDD:338493
		ANK repeat	1977..2008	CDD:293786
		ANK 5	1977..2006
		ANK repeat	2010..2041	CDD:293786
		ANK 6	2010..2039
		GGN	<2070..>2390	CDD:317988
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2098..2117
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2122..2169
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2382..2473
		DUF3454	2385..2441	CDD:314760
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0.928771	Normalized mean entropy	S2
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.950