DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment sty and SPRY2

DIOPT Version :9

Sequence 1:	NP_523902.2	Gene:	sty / 38424	FlyBaseID:	FBgn0014388	Length:	589	Species:	Drosophila melanogaster
Sequence 2:	NP_001305465.1	Gene:	SPRY2 / 10253	HGNCID:	11270	Length:	315	Species:	Homo sapiens

Alignment Length:	343	Identity:	114/343 - (33%)
Similarity:	160/343 - (46%)	Gaps:	72/343 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   168 QSAEPASNALGQP-PASPVT-----LAQPRPESERLTNEYVDTPLQHATRSQHPAGQQDNGQTTT 226
            |:........|:| |...:|     |:..:..:.|.||||.:.|    |....| |.:...:.:|
Human    16 QTPRDGGRQRGEPDPRDALTQQVHVLSLDQIRAIRNTNEYTEGP----TVVPRP-GLKPAPRPST 75

  Fly   227 HHLLLLPQRNQHLH-LQQHQQHLQQQQQQQQQQQQQQHLQHQQNQQHARLATTTQATSVGSDHTD 290
            .|      :::.|| |.:|              :|...|||.|....||...:...::|.|.
Human    76 QH------KHERLHGLPEH--------------RQPPRLQHSQVHSSARAPLSRSISTVSSG--- 117

  Fly   291 GLLHSHLQNSTTKPPASKQPAPPRLGMGLGLGLGLG-LNQPIITKQPTPATQKERMHALEELLQP 354
                   ..|:|:...|...:..||   ||.....| :...||..||            :..|:|
Human   118 -------SRSSTRTSTSSSSSEQRL---LGSSFSSGPVADGIIRVQP------------KSELKP 160

  Fly   355 GGAGGNGGPLVMAGDPSLLNPIVCPRCGRCRCEQCQSPRPLPQTWVCNKTCLCSAESVIDYASCL 419
            |..    .||  :.:...|:...|..||:|:|::|..|||||..|:|:|.|||||::||||.:|:
Human   161 GEL----KPL--SKEDLGLHAYRCEDCGKCKCKECTYPRPLPSDWICDKQCLCSAQNVIDYGTCV 219

  Fly   420 CCAKALFYHCARDNDLDCDDGNGTPCVDNPCSCGPYKRTQRWGWLGALSIFLPCLWFYWPMRGCM 484
            ||.|.|||||:.|     |:.|   |.||||||.......||..:|.:|:||||||.|.|.:||:
Human   220 CCVKGLFYHCSND-----DEDN---CADNPCSCSQSHCCTRWSAMGVMSLFLPCLWCYLPAKGCL 276

  Fly   485 KLCEKCYGRFAGRGCRCQ 502
            |||:.||.|....||||:
Human   277 KLCQGCYDRVNRPGCRCK 294

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sty	NP_523902.2	Sprouty	384..488	CDD:282994	55/103 (53%)
SPRY2	NP_001305465.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..39		5/22 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	51..140		30/126 (24%)
		Required for interaction with CAV1. /evidence=ECO:0000250\|UniProtKB:Q9QXV8	118..315		84/206 (41%)
		Required for interaction with TESK1. /evidence=ECO:0000269\|PubMed:17974561	178..315		66/125 (53%)
		Sprouty	183..284	CDD:398746	57/108 (53%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165144945
Domainoid	1	1.000	148	1.000	Domainoid score	I4467
eggNOG	1	0.900	-	-		E1_2CAWB
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	188	1.000	Inparanoid score	I3918
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1157681at2759
OrthoFinder	1	1.000	-	-		FOG0001173
OrthoInspector	1	1.000	-	-		otm41854
orthoMCL	1	0.900	-	-		OOG6_109465
Panther	1	1.100	-	-	LDO	PTHR12365
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4768
SonicParanoid	1	1.000	-	-		X723
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	13	12.790