Protein Alignment Ids and Galns

DIOPT Version :10

• Sequence 1: NP_647814.1
• Gene: Ids / 38423
• FlyBaseID: FBgn0035445
• Length: 512
• Species: Drosophila melanogaster
• Sequence 2: NP_057931.3
• Gene: Galns / 50917
• MGIID: 1355303
• Length: 520
• Species: Mus musculus
• Alignment Length: 464
• Identity: 119/464 - (25%)
• Similarity: 178/464 - (38%)
• Gaps: 123/464 - (26%)

  Fly     4 ARLLLSLMMPVLLDAAAPPRRPNVVMVIFDDLR-PVIGAYGDTLASTPYLDNFARGSHIFTRVYS 67
            |:.||.::..:.|.||..|:.||:|:::.||:. ..:|..|:....||.||..|....:|...||
Mouse     7 AQQLLLVLSALGLLAAGAPQPPNIVLLLMDDMGWGDLGVNGEPSRETPNLDRMAAEGMLFPSFYS 71

  Fly    68 QQSLCAPSRNSLLTGRRP-------DTLHLYDFYSYWRTFTG---NFTTLPQYFKEHGYYTYSCG 122
            ...||:|||.:|||||.|       ...|..:.|:......|   :...||:..|:.||.....|
Mouse    72 ANPLCSPSRAALLTGRLPIRNGFYTTNAHARNAYTPQEIMGGIPNSEHLLPELLKKAGYTNKIVG 136

  Fly   123 K-------VFHPGLSSNNTDDYPLSWSAP--AFRPRTEQFM-NSPVCPDKEGILRKNLICPVELQ 177
            |       .|||  ..:..|::   :.:|  .|.|...:.. |.||..|.|.:.|.....|:..:
Mouse   137 KWHLGHRPQFHP--LKHGFDEW---FGSPNCHFGPYDNKAKPNIPVYRDWEMVGRFYEEFPINRK 196

  Fly   178 ------TQPYKTLPDIESVAEALRFVGSRSRHS-QEPFFLAMGFHKPHINFRFPRQFLSRFNLSQ 235
                  ||.|        ..|||.|:  :::|: |.||||.......|......||||.
Mouse   197 TGEANLTQLY--------TQEALDFI--QTQHARQSPFFLYWAIDATHAPVYASRQFLG------ 245

  Fly   236 FYNYTEDSLKPPDMPAVAWNPYTDVRARDDFKHSNISFPYGPISPLQAAQIRQSYYASVSYVDDL 300
                                  |.:|.|           ||.               :|..:||.
Mouse   246 ----------------------TSLRGR-----------YGD---------------AVREIDDS 262

  Fly   301 FGKLIGGLD----LDETVVVALGDHGWSL-------GEHAEW--AKYSNFEVALRVPLIIRSPQF 352
            .||::..|.    ...|.|....|:|.:|       |.:..:  .|.:.||..:|.|.|...|..
Mouse   263 VGKILSLLQNLGISKNTFVFFTSDNGAALISAPNEGGSNGPFLCGKQTTFEGGMREPAIAWWPGH 327

  Fly   353 PVAQTKYYHGITELLDVFPTLVDLAGL-PKLDKCQSSQEL--TCGEGKSL-----YHQLMGLGRA 409
             :|..:..|.:..::|:|.|.:.|||| |..|:.....:|  |..:|:.:     |::    |..
Mouse   328 -IAAGQVSHQLGSIMDLFTTSLSLAGLKPPSDRVIDGLDLLPTMLKGQMMDRPIFYYR----GNT 387

  Fly   410 DEHVALSQY 418
            ...|.|.||
Mouse   388 LMAVTLGQY 396

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ids	NP_647814.1	iduronate-2-sulfatase	24..495	CDD:293754	112/444 (25%)
Galns	NP_057931.3	Catalytic domain. /evidence=ECO:0000250	24..377		107/422 (25%)
		GALNS	27..492	CDD:293776	112/444 (25%)