DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ids and STS

DIOPT Version :9

Sequence 1:	NP_647814.1	Gene:	Ids / 38423	FlyBaseID:	FBgn0035445	Length:	512	Species:	Drosophila melanogaster
Sequence 2:	NP_001307679.1	Gene:	STS / 412	HGNCID:	11425	Length:	590	Species:	Homo sapiens

Alignment Length:	526	Identity:	123/526 - (23%)
Similarity:	201/526 - (38%)	Gaps:	135/526 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 LLLSLMMPVLLDAAAPPRRPNVVMVIFDDL---RPVIGAYGDTLASTPYLDNFARGSHIFTRVYS 67
            |||..:......||:   |||:::|:.|||   .|  |.||:....||.:|..|.|....|:..:
Human    18 LLLFFLWEAESHAAS---RPNIILVMADDLGIGDP--GCYGNKTIRTPNIDRLASGGVKLTQHLA 77

  Fly    68 QQSLCAPSRNSLLTGRRPDTLHLYDFYSYWRT----FTGNFTTLP-------QYFKEHGYYTYSC 121
            ...||.|||.:.:|||.|....:   .|:.||    ||.:...||       :..|:.||.|...
Human    78 ASPLCTPSRAAFMTGRYPVRSGM---ASWSRTGVFLFTASSGGLPTDEITFAKLLKDQGYSTALI 139

  Fly   122 GKVFHPGLSSNNTDDY---PLSWSAPAFRPRTEQFMNSPVCPDKEGIL-----RKNLICPVELQT 178
            || :|.|:|.::..|:   ||......|...:  ..|...|...||.:     ::.:..|:::..
Human   140 GK-WHLGMSCHSKTDFCHHPLHHGFNYFYGIS--LTNLRDCKPGEGSVFTTGFKRLVFLPLQIVG 201

  Fly   179 QPYKTLPDIE---------SVAEALRFVGSRSRHSQEPFFLAMGF---HKP-----HINFRFPRQ 226
            ....||..:.         .|..:|.|:.:..      ..|.:||   .:|     ..|:...:|
Human   202 VTLLTLAALNCLGLLHVPLGVFFSLLFLAALI------LTLFLGFLHYFRPLNCFMMRNYEIIQQ 260

  Fly   227 FLSRFNLSQ-----FYNYTEDSLKPPDMPAVAW-NPYTDVRARDDFKHSNISFPYGPISPLQAAQ 285
            .:|..||:|     ...:.:.:.:.|.:..::: :.:|.:.:..||...:....||.
Human   261 PMSYDNLTQRLTVEAAQFIQRNTETPFLLVLSYLHVHTALFSSKDFAGKSQHGVYGD-------- 317

  Fly   286 IRQSYYASVSYVDDLFGKLIGGLD----LDETVVVALGD--------------HGWSLGEHAEWA 332
                   :|..:|...|:::..||    .::|::....|              ||.|.|.: :..
Human   318 -------AVEEMDWSVGQILNLLDELRLANDTLIYFTSDQGAHVEEVSSKGEIHGGSNGIY-KGG 374

  Fly   333 KYSNFEVALRVPLIIRSPQFPVAQTKYYHGITELLDVFPTLVDLAGLPKLDKCQSSQELTCGEGK 397
            |.:|:|..:|||.|:|.|:...|..|.... |..:|:|||:..|||.|       ..|....:|:
Human   375 KANNWEGGIRVPGILRWPRVIQAGQKIDEP-TSNMDIFPTVAKLAGAP-------LPEDRIIDGR 431

  Fly   398 SLYHQLMGLGRADEHVALSQYPRPGMLPTKHPNSDKPKLRNIKIMGYSLRTDIYRYTMWVRFHAQ 462
            .|...|.|..:..:|..|..|                               ...|...||:|.|
Human   432 DLMPLLEGKSQRSDHEFLFHY-------------------------------CNAYLNAVRWHPQ 465

  Fly   463 NFSRDW 468
            |.:..|
Human   466 NSTSIW 471

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ids	NP_647814.1	AslA	21..509	CDD:225661	118/511 (23%)
Ids	NP_647814.1	iduronate-2-sulfatase	24..495	CDD:293754	118/508 (23%)
STS	NP_001307679.1	AslA	30..555	CDD:225661	120/514 (23%)
STS	NP_001307679.1	ES	33..557	CDD:293778	118/508 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3119
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S5833
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.760