DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ids and sulf2a

DIOPT Version :9

Sequence 1:	NP_647814.1	Gene:	Ids / 38423	FlyBaseID:	FBgn0035445	Length:	512	Species:	Drosophila melanogaster
Sequence 2:	XP_005169326.1	Gene:	sulf2a / 393910	ZFINID:	ZDB-GENE-040426-759	Length:	874	Species:	Danio rerio

Alignment Length:	519	Identity:	116/519 - (22%)
Similarity:	194/519 - (37%)	Gaps:	150/519 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    24 RPNVVMVIFDDLRPVIGAYGDTLASTPYLDNFAR-----GSHIFTRVYSQQSLCAPSRNSLLTGR 83
            |||:::::.||....:|       |...::...|     |:| |:..::...:|.|||:::|||:
Zfish    45 RPNMILILTDDQDIELG-------SMQAMNKTKRIMMQGGTH-FSNAFATTPMCCPSRSTILTGK 101

  Fly    84 RPDTLHLYDFYSYWRTFTGNFTTL---------PQYFKEH----GYYTYSCGKVFHPGLSSNNTD 135
            .....|         |:|.|....         |..|..|    ||.|...||.    |:..|..
Zfish   102 YVHNHH---------TYTNNENCSSPSWQAHHEPHTFAVHLNNSGYRTAFFGKY----LNEYNGS 153

  Fly   136 DYPLSWSAPAFRPRTEQFMNSPVCPDKEGILRKNLICPVELQTQ-PYKTLPDIESVAEALRFVGS 199
            ..|..|.......:..:|.|..:|  :.||..|:       .|| |...|.|:.:......|..|
Zfish   154 YVPPGWREWVALVKNSRFYNYTLC--RNGIREKH-------GTQYPKDYLTDVITNDSINYFRMS 209

  Fly   200 RSRHSQEPFFLAMGFHKPHINFRFPRQFLSRF-NLSQF----YNYTEDSLKPPDMPAVAWNPYTD 259
            :..:...|..:.:....||.......|:.|.| |.||.    ||:..:    ||
Zfish   210 KRMYPHRPVMMVLSHAAPHGPEDAAPQYSSAFPNASQHITPSYNHAPN----PD----------- 259

  Fly   260 VRARDDFKHSNISFPYGPISP--------LQAAQIRQSYYASVSYVDDLFGKLIGGLDLDETVVV 316
                   ||..:.:. ||:.|        ||..:: |:..:....|:.::..|:...:||.|.::
Zfish   260 -------KHWILRYT-GPMKPVHMQFTNMLQRRRL-QTLLSVDDSVEKVYNMLVETGELDNTYII 315

  Fly   317 ALGDHGWSLGEHA-EWAKYSNFEVALRVPLIIRSPQFPVAQTKYYHGITELLDVFPTLVDLAGLP 380
            .:.|||:.:|:.. ...|...:|..:|:|..:|.|.........:  |....|:.|||:|:||:
Zfish   316 YMSDHGYHIGQFGLVKGKSMPYEFDIRIPFYVRGPNVEAGAINPH--IVLNTDLAPTLLDMAGI- 377

  Fly   381 KLDKCQSSQELTCGEGKSLYHQLMGLGRADEHVALSQYPRPGMLPTKHP-NSDKPKLRNIKIMGY 444
                 ...|::   :|||:..                     :|.|:.| ||
Zfish   378 -----DIPQDM---DGKSILK---------------------LLETERPVNS------------- 400

  Fly   445 SLRTDIYRYTMWVRFHAQNFSRDWHDVY----GEELYDHRLDSGEELNLMPLPQFDDVRQRLRR 504
                       :.|||:...::.|.|.:    |:.|  |:|..|:|:....||::..||...:|
Zfish   401 -----------FTRFHSYKKAKLWRDSFLVERGKPL--HKLADGKEVEQNSLPKYQRVRDLCQR 451

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ids	NP_647814.1	AslA	21..509	CDD:225661	116/519 (22%)
Ids	NP_647814.1	iduronate-2-sulfatase	24..495	CDD:293754	113/508 (22%)
sulf2a	XP_005169326.1	G6S	45..387	CDD:293766	93/406 (23%)
		DUF3740	541..670	CDD:289325
		ALP_like	<758..807	CDD:304875
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3119
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810