DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ids and Ids

DIOPT Version :9

Sequence 1:	NP_647814.1	Gene:	Ids / 38423	FlyBaseID:	FBgn0035445	Length:	512	Species:	Drosophila melanogaster
Sequence 2:	XP_038956467.1	Gene:	Ids / 363513	RGDID:	1560491	Length:	554	Species:	Rattus norvegicus

Alignment Length:	540	Identity:	240/540 - (44%)
Similarity:	316/540 - (58%)	Gaps:	58/540 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 LLLSLMMPVLLDAA---APPRRPNVVMVIFDDLRPVIGAYGDTLASTPYLDNFARGSHIFTRVYS 67
            |||......|:.||   :.....|::::|.|||||.:|.|||.|..:|.:|..|..|.:|...::
  Rat    19 LLLGFFCIALVSAAQGNSATDALNILLIIVDDLRPSLGCYGDKLVRSPNIDQLASHSIVFENAFA 83

  Fly    68 QQSLCAPSRNSLLTGRRPDTLHLYDFYSYWRTFTGNFTTLPQYFKEHGYYTYSCGKVFHPGLSSN 132
            ||::|||||.|.||||||||..||||.||||..:|||:|:||||||:||.|.|.|||||||:|||
  Rat    84 QQAVCAPSRVSFLTGRRPDTTRLYDFNSYWRVHSGNFSTIPQYFKENGYVTMSVGKVFHPGISSN 148

  Fly   133 NTDDYPLSWSAPAFRPRTEQFMNSPVCPDKEGILRKNLICPVELQTQPYKTLPDIESVAEALRFV 197
            ::||||.|||.|.:.|.:|::.|:..|..::|.|..||:|||::...|..||||.:|..||:|.:
  Rat   149 HSDDYPYSWSFPPYHPSSEKYENTKTCKGQDGKLHTNLLCPVDVADVPEGTLPDKQSTEEAIRLL 213

  Fly   198 GSRSRHSQEPFFLAMGFHKPHINFRFPRQFLSRFNLSQFYNYTEDSLKPPDMPAVAWNPYTDVRA 262
             .:.:.|..|||||:|:|||||.||:|::|...:.|... ....|...|..:|.||:||:.|:|.
  Rat   214 -EKMKTSVSPFFLAVGYHKPHIPFRYPKEFQKLYPLENM-TLAPDPHVPDSLPPVAYNPWMDIRE 276

  Fly   263 RDDFKHSNISFPYGPISPLQAAQIRQSYYASVSYVDDLFGKLIGGLD----LDETVVVALGDHGW 323
            |:|.:..|||.|||||......:|||||:|||||:|...|.|:..||    ...|::..:.||||
  Rat   277 REDVQALNISVPYGPIPVDFQRKIRQSYFASVSYLDTQVGHLLSALDDLRLAHNTIIAFMSDHGW 341

  Fly   324 SLGEHAEWAKYSNFEVALRVPLIIRSP----QFPVAQTKYY-------------------HGITE 365
            :||||.||||||||:|..||||:...|    ..|.|..|.:                   ..:.|
  Rat   342 ALGEHGEWAKYSNFDVTTRVPLMFYVPGKTALLPAAGEKLFPYQDPFDPASELMGAGRRTEDLVE 406

  Fly   366 LLDVFPTLVDLAGLPKLDKC--QSSQELTCGEGKSL--YHQLMGL-------GRADEHVALSQYP 419
            |:.:||||..|||:|....|  .|.....|.||.:|  |.||..|       |...|.:|.||||
  Rat   407 LVSLFPTLAGLAGMPVPPWCPIPSFHVELCREGHNLQRYLQLHDLEEDPYLFGNPRELIAYSQYP 471

  Fly   420 RPGMLPTKHPNSDKPKLRNIKIMGYSLRTDIYRYTMWVRFHAQNFSRDWHDVYGEELY------- 477
            ||...|  ..|||||.|::||:||||:||..||||:||.|....|..::.|::..|||
  Rat   472 RPADFP--QWNSDKPSLKDIKVMGYSIRTIDYRYTVWVGFSPTEFLANFSDIHAGELYFVDSDPL 534

  Fly   478 -DHRL--DS---GEELNLMP 491
             ||.:  ||   |..|:|.|
  Rat   535 QDHNVYNDSQHGGLLLSLRP 554

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ids	NP_647814.1	AslA	21..509	CDD:225661	234/522 (45%)
Ids	NP_647814.1	iduronate-2-sulfatase	24..495	CDD:293754	234/519 (45%)
Ids	XP_038956467.1	iduronate-2-sulfatase	42..545	CDD:293754	233/514 (45%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	323	1.000	Domainoid score	I1177
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H169
Inparanoid	1	1.050	390	1.000	Inparanoid score	I1931
OMA	1	1.010	-	-		QHG52284
OrthoDB	1	1.010	-	-		D1353742at2759
OrthoFinder	1	1.000	-	-		FOG0007173
OrthoInspector	1	1.000	-	-		oto98329
orthoMCL	1	0.900	-	-		OOG6_105448
Panther	1	1.100	-	-	LDO	PTHR45953
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X6053
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	12	11.980