Protein Alignment Ids and IDS

DIOPT Version :10

• Sequence 1: NP_647814.1
• Gene: Ids / 38423
• FlyBaseID: FBgn0035445
• Length: 512
• Species: Drosophila melanogaster
• Sequence 2: NP_000193.1
• Gene: IDS / 3423
• HGNCID: 5389
• Length: 550
• Species: Homo sapiens
• Alignment Length: 517
• Identity: 232/517 - (44%)
• Similarity: 310/517 - (59%)
• Gaps: 53/517 - (10%)

  Fly    26 NVVMVIFDDLRPVIGAYGDTLASTPYLDNFARGSHIFTRVYSQQSLCAPSRNSLLTGRRPDTLHL 90
            ||:::|.|||||.:|.|||.|..:|.:|..|..|.:|...::||::|||||.|.||||||||..|
Human    38 NVLLIIVDDLRPSLGCYGDKLVRSPNIDQLASHSLLFQNAFAQQAVCAPSRVSFLTGRRPDTTRL 102

  Fly    91 YDFYSYWRTFTGNFTTLPQYFKEHGYYTYSCGKVFHPGLSSNNTDDYPLSWSAPAFRPRTEQFMN 155
            |||.||||...|||:|:||||||:||.|.|.|||||||:|||:|||.|.|||.|.:.|.:|::.|
Human   103 YDFNSYWRVHAGNFSTIPQYFKENGYVTMSVGKVFHPGISSNHTDDSPYSWSFPPYHPSSEKYEN 167

  Fly   156 SPVCPDKEGILRKNLICPVELQTQPYKTLPDIESVAEALRFVGSRSRHSQEPFFLAMGFHKPHIN 220
            :..|...:|.|..||:|||::...|..||||.:|..:|::.: .:.:.|..|||||:|:|||||.
Human   168 TKTCRGPDGELHANLLCPVDVLDVPEGTLPDKQSTEQAIQLL-EKMKTSASPFFLAVGYHKPHIP 231

  Fly   221 FRFPRQFLSRFNLSQFYNYTEDSLKPPDMPAVAWNPYTDVRARDDFKHSNISFPYGPISPLQAAQ 285
            ||:|::|...:.|... ....|...|..:|.||:||:.|:|.|:|.:..|||.|||||......:
Human   232 FRYPKEFQKLYPLENI-TLAPDPEVPDGLPPVAYNPWMDIRQREDVQALNISVPYGPIPVDFQRK 295

  Fly   286 IRQSYYASVSYVDDLFGKLIGGLD----LDETVVVALGDHGWSLGEHAEWAKYSNFEVALRVPLI 346
            |||||:|||||:|...|:|:..||    .:.|::....||||:||||.||||||||:||..||||
Human   296 IRQSYFASVSYLDTQVGRLLSALDDLQLANSTIIAFTSDHGWALGEHGEWAKYSNFDVATHVPLI 360

  Fly   347 I----RSPQFPVAQTKYY-------------------HGITELLDVFPTLVDLAGLPKLDKC--Q 386
            .    |:...|.|..|.:                   ..:.||:.:||||..||||....:|  .
Human   361 FYVPGRTASLPEAGEKLFPYLDPFDSASQLMEPGRQSMDLVELVSLFPTLAGLAGLQVPPRCPVP 425

  Fly   387 SSQELTCGEGKSL--YHQLMGL-------GRADEHVALSQYPRPGMLPTKHPNSDKPKLRNIKIM 442
            |.....|.|||:|  :.:...|       |...|.:|.||||||..:|  ..|||||.|::||||
Human   426 SFHVELCREGKNLLKHFRFRDLEEDPYLPGNPRELIAYSQYPRPSDIP--QWNSDKPSLKDIKIM 488

  Fly   443 GYSLRTDIYRYTMWVRFHAQNFSRDWHDVYGEELY--------DHRL--DS-GEELNLMPLP 493
            |||:||..||||:||.|:...|..::.|::..|||        ||.:  || |.:|..:.:|
Human   489 GYSIRTIDYRYTVWVGFNPDEFLANFSDIHAGELYFVDSDPLQDHNMYNDSQGGDLFQLLMP 550

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ids	NP_647814.1	iduronate-2-sulfatase	24..495	CDD:293754	232/517 (45%)
IDS	NP_000193.1	iduronate-2-sulfatase	38..540	CDD:293754	228/505 (45%)