DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ids and Sulf2

DIOPT Version :9

Sequence 1:	NP_647814.1	Gene:	Ids / 38423	FlyBaseID:	FBgn0035445	Length:	512	Species:	Drosophila melanogaster
Sequence 2:	NP_001030099.1	Gene:	Sulf2 / 311642	RGDID:	1305078	Length:	875	Species:	Rattus norvegicus

Alignment Length:	523	Identity:	112/523 - (21%)
Similarity:	188/523 - (35%)	Gaps:	159/523 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    24 RPNVVMVIFDDLRPVIGAYGDTLASTPYLDNFAR-----GSHIFTRVYSQQSLCAPSRNSLLTGR 83
            |||:::|:.||....:|       |...::...|     |:| |...:....:|.|||:|:|||:
  Rat    43 RPNIILVLTDDQDVELG-------SMQVMNKTRRIMEQGGAH-FINAFVTTPMCCPSRSSILTGK 99

  Fly    84 RPDTLHLYDFYS--------YW------RTFTGNFTTLPQYFKEHGYYTYSCGKVFHPGLSSNNT 134
               .:|.::.|:        .|      |||.       .|....||.|...||.    |:..|.
  Rat   100 ---YVHNHNTYTNNENCSSPSWQAQHESRTFA-------VYLNSTGYRTAFFGKY----LNEYNG 150

  Fly   135 DDYPLSWSAPAFRPRTEQFMNSPVCPDKEGILRKNLICPVELQTQPYKT--LPDIESVAEALRFV 197
            ...|..|.......:..:|.|..:|  :.|:..|:        ...|.|  |.|:.:......|.
  Rat   151 SYVPPGWKEWVGLLKNSRFYNYTLC--RNGMKEKH--------GSDYSTDYLTDLITNDSVSFFR 205

  Fly   198 GSRSRHSQEPFFLAMGFHKPHINFRFPRQFLSRF-NLSQF----YNYTEDSLKPPDMPAVAWNPY 257
            .|:..:...|..:.:....||.......|:...| |.||.    |||..:    ||
  Rat   206 TSKKMYPHRPVLMVISHAAPHGPEDSAPQYSRLFPNASQHITPSYNYAPN----PD--------- 257

  Fly   258 TDVRARDDFKHSNISFPYGPISPLQ---AAQIRQSYYASVSYVDD----LFGKLIGGLDLDETVV 315
                     ||..:.:. ||:.|:.   ...:::....::..|||    ::..|:...:||.|.:
  Rat   258 ---------KHWIMRYT-GPMKPIHMEFTNMLQRKRLQTLMSVDDSMETIYDMLVETGELDNTYI 312

  Fly   316 VALGDHGWSLGEHA-EWAKYSNFEVALRVPLIIRSPQFPVAQTKYYHGITELLDVFPTLVDLAGL 379
            |...|||:.:|:.. ...|...:|..:|||..:|.|.........:  |...:|:.||::|:|||
  Rat   313 VYTADHGYHIGQFGLVKGKSMPYEFDIRVPFYVRGPSVEAGSLNPH--IVLNIDLAPTILDIAGL 375

  Fly   380 PKLDKCQSSQELTCG-EGKSLYHQLMGLGRADEHVALSQYPRPGMLPTKHPNSDKPKLRNIKIMG 443
                      ::... :|||:...|                          :|::|.
  Rat   376 ----------DIPADMDGKSILKLL--------------------------DSERPV-------- 396

  Fly   444 YSLRTDIYRYTMWVRFHAQNFSRDWHDVY----GEELYDHRLDSGEELNLMP---LPQFDDVRQR 501
                         .|||.:...|.|.|.:    |:.|:..   .|:::|...   ||::..|:..
  Rat   397 -------------NRFHLKKKLRVWRDSFLVERGKLLHKR---EGDKVNAQEENFLPKYQRVKDL 445

  Fly   502 LRR 504
            .:|
  Rat   446 CQR 448

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ids	NP_647814.1	AslA	21..509	CDD:225661	112/523 (21%)
Ids	NP_647814.1	iduronate-2-sulfatase	24..495	CDD:293754	110/512 (21%)
Sulf2	NP_001030099.1	G6S	43..385	CDD:293766	93/408 (23%)
		DUF3740	533..666	CDD:403667
		ALP_like	<754..803	CDD:419962
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3119
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810