DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ids and Sulf1

DIOPT Version :9

Sequence 1:	NP_647814.1	Gene:	Ids / 38423	FlyBaseID:	FBgn0035445	Length:	512	Species:	Drosophila melanogaster
Sequence 2:	XP_006495573.1	Gene:	Sulf1 / 240725	MGIID:	2138563	Length:	1121	Species:	Mus musculus

Alignment Length:	517	Identity:	111/517 - (21%)
Similarity:	189/517 - (36%)	Gaps:	155/517 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    24 RPNVVMVIFDDLRPVIGAYGDTLASTPYLDNFARGSHIFTRVYSQQSLCAPSRNSLLTGRRPDTL 88
            |||:::|:.||....:|:. ..:..|..:  ..:|...||..:....:|.|||:|:|||:   .:
Mouse    42 RPNIILVLTDDQDVELGSL-QVMNKTRKI--MEQGGATFTNAFVTTPMCCPSRSSMLTGK---YV 100

  Fly    89 HLYDFYS--------YW------RTFTGNFTTLPQYFKEHGYYTYSCGKVFHPGLSSNNTDDYPL 139
            |.::.|:        .|      |||.       .|....||.|...||..         ::|..
Mouse   101 HNHNVYTNNENCSSPSWQAMHEPRTFA-------VYLNNTGYRTAFFGKYL---------NEYNG 149

  Fly   140 SWSAPAFRP-----RTEQFMNSPVCPDKEGILRKNLICPVELQTQPYKTLPDIESVAEALRFVGS 199
            |:..|.:|.     :..:|.|..||  :.||..|:   ..:.....:..|...||:.   .|..|
Mouse   150 SYIPPGWREWLGLIKNSRFYNYTVC--RNGIKEKH---GFDYAKDYFTDLITNESIN---YFKMS 206

  Fly   200 RSRHSQEPFFLAMGFHKPHINFRFPRQFLSRF-NLSQF----YNYTEDSLKPPDMPAVAWNPYTD 259
            :..:...|..:.:....||.......||...: |.||.    |||.      |:|.
Mouse   207 KRMYPHRPIMMVISHAAPHGPEDSAPQFSKLYPNASQHITPSYNYA------PNMD--------- 256

  Fly   260 VRARDDFKHSNISFPYGPISPLQ---AAQIRQSYYASVSYVDD----LFGKLIGGLDLDETVVVA 317
                   ||..:.:. ||:.|:.   ...:::....::..|||    |:..|:...:||.|.::.
Mouse   257 -------KHWIMQYT-GPMLPIHMEFTNVLQRKRLQTLMSVDDSVERLYNMLVESGELDNTYIIY 313

  Fly   318 LGDHGWSLGEHA-EWAKYSNFEVALRVPLIIRSPQFP----VAQTKYYHGITELLDVFPTLVDLA 377
            ..|||:.:|:.. ...|...::..:|||..||.|...    |.|      |...:|:.||::|:|
Mouse   314 TADHGYHIGQFGLVKGKSMPYDFDIRVPFFIRGPSIEPGSIVPQ------IVLNIDLAPTILDIA 372

  Fly   378 GLPKLDKCQSSQELTCGEGKSLYHQLMGLGRADEHVALSQYPRPGMLPTKHPNSDKPKLRNIKIM 442
            ||      .|..::   :|||:             :.|....:||.
Mouse   373 GL------DSPSDV---DGKSV-------------LKLLDLEKPGN------------------- 396

  Fly   443 GYSLRTDIYRYTMWVRFHAQNFSRDWHDVYGEE---LYDHRLDSGEELNLM-PLPQFDDVRQ 500
                           ||.....::.|.|.:..|   ....:.:||:.:... .||:::.|::
Mouse   397 ---------------RFRTNKKAKIWRDTFLVERGKFLRKKEESGKNIQQSNHLPKYERVKE 443

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ids	NP_647814.1	AslA	21..509	CDD:225661	111/517 (21%)
Ids	NP_647814.1	iduronate-2-sulfatase	24..495	CDD:293754	110/510 (22%)
Sulf1	XP_006495573.1	G6S	42..384	CDD:293766	96/409 (23%)
		DUF3740	534..674	CDD:403667
		ALP_like	<767..816	CDD:419962
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3119
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810