DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ids and Ids

DIOPT Version :9

Sequence 1:	NP_647814.1	Gene:	Ids / 38423	FlyBaseID:	FBgn0035445	Length:	512	Species:	Drosophila melanogaster
Sequence 2:	XP_006527908.1	Gene:	Ids / 15931	MGIID:	96417	Length:	595	Species:	Mus musculus

Alignment Length:	576	Identity:	236/576 - (40%)
Similarity:	321/576 - (55%)	Gaps:	100/576 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 ITARLLLSLMMP---VLLDAAAPPRRP----NVVMVIFDDLRPVIGAYGDTLASTPYLDNFARGS 59
            |..:|..||::.   :.|::||.....    |::::|.|||||.:|.|||.|..:|.:|..|..|
Mouse     9 IWRQLSFSLLLGSFCIALESAAQGNSATDALNILLIIVDDLRPSLGCYGDKLVRSPNIDQLASHS 73

  Fly    60 HIFTRVYSQQSLCAPSRNSLLTGRRPDTLHLYDFYSYWRTFTGNFTTLPQYFKEHGYYTYSCGKV 124
            .:|...::||::|||||.|.||||||||..||||.||||..:|||:|:||||||:||.|.|.|||
Mouse    74 VLFQNAFAQQAVCAPSRVSFLTGRRPDTTRLYDFNSYWRVHSGNFSTIPQYFKENGYVTMSVGKV 138

  Fly   125 FHPGLSSNNTDDYPLSWSAPAFRPRTEQFMNSPVCPDKEGILRKNLICPVELQTQPYKTLPDIES 189
            ||||:|||::||||.|||.|.:.|.:|::.|:..|..::|.|..||:|||::...|..||||.:|
Mouse   139 FHPGISSNHSDDYPYSWSFPPYHPSSEKYENTKTCKGQDGKLHANLLCPVDVADVPEGTLPDKQS 203

  Fly   190 VAEALRFVGSRSRHSQEPFFLAMGFHKPHINFRFPRQFLSRFNLSQFYNYTEDSLKPPDMPAVAW 254
            ..||:|.: .:.:.|..|||||:|:|||||.||:|::|...:.|... ....|...|..:|.||:
Mouse   204 TEEAIRLL-EKMKTSASPFFLAVGYHKPHIPFRYPKEFQKLYPLENI-TLAPDPHVPDSLPPVAY 266

  Fly   255 NPYTDVRARDDFKHSNISFPYGPI------------------SPLQAA----------------- 284
            ||:.|:|.|:|.:..|||.|||||                  |..:::
Mouse   267 NPWMDIREREDVQALNISVPYGPIPEDFQHRCSICSILILRQSSCESSWKEHLLLLSRGFQLPSE 331

  Fly   285 --------QIRQSYYASVSYVDDLFGKLIGGLD----LDETVVVALGDHGWSLGEHAEWAKYSNF 337
                    :|||||:|||||:|...|.::..||    ...|::....||||:||||.||||||||
Mouse   332 VLCLFAERKIRQSYFASVSYLDTQVGHVLSALDDLRLAHNTIIAFTSDHGWALGEHGEWAKYSNF 396

  Fly   338 EVALRVPLII----RSPQFPVAQTKYY-------------------HGITELLDVFPTLVDLAGL 379
            :||.||||::    |:...|.|..|.:                   ..:.||:.:||||..||||
Mouse   397 DVATRVPLMLYVPGRTAPLPAAGQKLFPYRDPFDPASDWMDAGRHTEDLVELVSLFPTLAGLAGL 461

  Fly   380 PKLDKC--QSSQELTCGEGKSL--YHQLMGL-------GRADEHVALSQYPRPGMLPTKHPNSDK 433
            |...:|  .|.....|.||::|  :.||..|       |...|.:|.||||||...|  ..||||
Mouse   462 PVPPRCPIPSFHVELCREGQNLQKHLQLHDLEEEPDLFGNPRELIAYSQYPRPADFP--QWNSDK 524

  Fly   434 PKLRNIKIMGYSLRTDIYRYTMWVRFHAQNFSRDWHDVYGEELY--------DHRL 481
            |.|.:||:||||:||..||||:||.|....|..::.|::..|||        ||.:
Mouse   525 PSLNDIKVMGYSIRTVDYRYTVWVGFDPSEFLANFSDIHAGELYFVDSDPLQDHNV 580

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ids	NP_647814.1	AslA	21..509	CDD:225661	229/554 (41%)
Ids	NP_647814.1	iduronate-2-sulfatase	24..495	CDD:293754	229/551 (42%)
Ids	XP_006527908.1	iduronate-2-sulfatase	40..586	CDD:293754	227/538 (42%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167831440
Domainoid	1	1.000	360	1.000	Domainoid score	I954
eggNOG	1	0.900	-	-		E1_COG3119
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H169
Inparanoid	1	1.050	429	1.000	Inparanoid score	I1721
Isobase	1	0.950	-	0	Normalized mean entropy	S5833
OMA	1	1.010	-	-		QHG52284
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0007173
OrthoInspector	1	1.000	-	-		oto94825
orthoMCL	1	0.900	-	-		OOG6_105448
Panther	1	1.100	-	-	LDO	PTHR45953
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R9523
SonicParanoid	1	1.000	-	-		X6053
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	16	15.740