Protein Alignment CG12010 and SAP1

DIOPT Version :10

• Sequence 1: NP_728878.1
• Gene: CG12010 / 38421
• FlyBaseID: FBgn0035443
• Length: 717
• Species: Drosophila melanogaster
• Sequence 2: NP_010966.1
• Gene: SAP1 / 856771
• SGDID: S000000849
• Length: 897
• Species: Saccharomyces cerevisiae
• Alignment Length: 735
• Identity: 173/735 - (23%)
• Similarity: 296/735 - (40%)
• Gaps: 168/735 - (22%)

  Fly   121 DDVRI-FLRHLKLTKGCSVQHRRLVQLGIASVEIFDAPGVADDECFEIAHDAELLLADIRL---- 180
            :::|: |:....|:...|.||:.       .:|..|.|...:.|.:...:.:|.:|.|:..
Yeast   187 ENIRVNFVPSKPLSNNASRQHKN-------PIEHNDPPLKKETELYSDKYISEPILIDLTNDEDD 244

  Fly   181 ------------------GMPFSL-DFIFKYLPHSFERPMEQLE-----KLLE-----------T 210
                              |..|.: |:...:.....|...|:.|     |.||           |
Yeast   245 HDVGILKGHNVFDEEESDGFEFDVSDYYDNFSEVDVEEEEEEKEERRRIKTLEAIQQQMSDLSVT 309

  Fly   211 SKISFS--------------HRFPTTA-----LVVGP---VDCGKSGLLSEFLRRHSCNCFYITA 253
            |..|.:              ...||||     |...|   ||...|   :..|:.||........
Yeast   310 SSTSSNKSVSSSENVPGSCIQSLPTTAPALPSLPPPPLLNVDRASS---TGALKPHSLETSTTMD 371

  Fly   254 SQVLRS-------------YPGETEEELRRIFQAAQTF----KEKLRPLL------PIVIL-IED 294
            |..:|:             |...|:.....|.::..||    |...:|::      |...| :.:
Yeast   372 SSKIRNPQISKLMKNNHVPYLKGTKSTPTLITKSTPTFITRSKSNTKPIIKSNASSPTSSLTVPN 436

  Fly   295 LELLCPSTAVADAKNSSNSLRISAELYKLLDALPRGIICLATSGVPDSLHEHARRRFVREVTINM 359
            ..:..|.||...||...||.::::............|:...|:.||:|..:.......|.|:.:.
Yeast   437 SVIQKPKTAAMAAKRVLNSKKVASNPALNTTKKSHPILKSKTAKVPNSSSKKTSSHPSRPVSNSK 501

  Fly   360 P-SEG---QRRQLVEHLCEVHELN--------ISQTLLEHIARNTQGYVIADLTLLLRRVQQQLL 412
            | |.|   .::........:.:.|        |....:|.:...       |.|.....:.:|
Yeast   502 PYSHGASQNKKPSKNQTTSMSKTNRKIPAQKKIGSPKIEDVGTE-------DATEHATSLNEQ-- 557

  Fly   413 TKDDFDIEHIFLKSLSQTQPSAS-RSTDVRVSK------MTAGFEV----IGGMEALKRTLQVSV 466
             :::.:|:...|:.:.:.:...| :..|.:.:|      :..|.||    |.|:|:.|.:|:.:|
Yeast   558 -REEPEIDKKVLREILEDEIIDSLQGVDRQAAKQIFAEIVVHGDEVHWDDIAGLESAKYSLKEAV 621

  Fly   467 LAGIRQSAAFARFGLSLP-KGVLLYGPPGCAKTTVAKCLAKEADMTFIATSAAEVYSPYVGCAER 530
            :....:...|.  ||..| :|:||:||||..||.:|:.:|.|:..||.:.||:.:.|.|:|.:|:
Yeast   622 VYPFLRPDLFR--GLREPVRGMLLFGPPGTGKTMLARAVATESHSTFFSISASSLTSKYLGESEK 684

  Fly   531 FISRIFDTARKNAPCLIFLDEIDSLVGRRTVSSGGGGGQVQLRILSTLLTEMNGI--VGGGSQQ- 592
            .:..:|..|:|.:|.:||:|||||::|.|   :.....:...||.:..|.:.:.:  ...||.:
Yeast   685 LVRALFAIAKKLSPSIIFVDEIDSIMGSR---NNENENESSRRIKNEFLVQWSSLSSAAAGSNKS 746

  Fly   593 --------------HILVVAATNRPDMIDDALLRPGRFDKLIHVPAPDEKSRLALLK--LHSQRM 641
                          .:||:||||.|..||:|..|  ||.:..::|.|::::|....|  |..|:.
Yeast   747 NTNNSDTNGDEDDTRVLVLAATNLPWSIDEAARR--RFVRRQYIPLPEDQTRHVQFKKLLSHQKH 809

  Fly   642 PFHENVFLQEIAARTDRYSGADLCNLCNEAAIEAFQRDF--KATEIE--------LQDFEKVLTK 696
            ...|:.| .|:...|:.|||:|:.:|..:||:... ||.  |..|.|        |.||:..|..
Yeast   810 TLTESDF-DELVKITEGYSGSDITSLAKDAAMGPL-RDLGDKLLETEREMIRPIGLVDFKNSLVY 872

  Fly   697 QKSSLTQSQIDGYYKFAYRF 716
            .|.|::|..:..|.|:|.:|
Yeast   873 IKPSVSQDGLVKYEKWASQF 892

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG12010	NP_728878.1	CDC48	<220..713	CDD:273521	146/577 (25%)
SAP1	NP_010966.1	Herpes_BLLF1	<353..543	CDD:282904	35/192 (18%)
		McrB	<539..>659	CDD:441011	32/131 (24%)
		RecA-like_VPS4-like	607..788	CDD:410917	61/187 (33%)
		AAA_lid_3	815..850	CDD:465537	12/36 (33%)
		Vps4_C	<847..893	CDD:462762	14/46 (30%)