Protein Alignment CG12010 and AFG2B

DIOPT Version :10

• Sequence 1: NP_728878.1
• Gene: CG12010 / 38421
• FlyBaseID: FBgn0035443
• Length: 717
• Species: Drosophila melanogaster
• Sequence 2: NP_076968.2
• Gene: AFG2B / 79029
• HGNCID: 28762
• Length: 753
• Species: Homo sapiens
• Alignment Length: 775
• Identity: 247/775 - (31%)
• Similarity: 377/775 - (48%)
• Gaps: 117/775 - (15%)

  Fly     1 MHHNQSDFPTFPLSL---LDDSDLEPQRCYI-PAWENSTGT---GWYRCHLCDGSYAVCWVTPRA 58
            |..:...||..||..   ||..|...|||.: ||..::.|.   ...:..|.||...:|...||.
Human     1 MAPDSDPFPEGPLLKLLPLDARDRGTQRCRLGPAALHALGARLGSAVKISLPDGGSCLCTAWPRR 65

  Fly    59 GS-------ETCCFLDGIVTSLTRFSPTNQRLVLLEPLKLVPC--VKRI---------------- 98
            ..       :..|...|.....:|    ::|.:.|..|.||||  ::|:
Human    66 DGADGFVQLDPLCASPGAAVGASR----SRRSLSLNRLLLVPCPPLRRVAVWPVLRERAGAPGAR 126

  Fly    99 --SCVITVTQELLQRPPVSLEDL---KDDVRIFLRHLKLTKGCS-------VQHRRLVQLGIASV 151
              :.|:...||||:..|:||..:   .......:..|.:..|..       |..|..|.||
Human   127 NTAAVLEAAQELLRNRPISLGHVVVAPPGAPGLVAALHIVGGTPSPDPAGLVTPRTRVSLG---- 187

  Fly   152 EIFDAPGVADDECFEIAHDAELLLADIRLGMPFSLDFIFKY--LPHSFERPMEQLEKLLETSKIS 214
              .:.|..|..:       .|:.|.    |:..:.|.:.:.  ||..:.|.:..|...:
Human   188 --GEPPSEAQPQ-------PEVPLG----GLSEAADSLRELLRLPLRYPRALTALGLAV------ 233

  Fly   215 FSHRFPTTALVVGPVDCGKSGLLSEFLRRHSCNCFYITASQVLRSYPGETEEELRRIFQAAQTFK 279
                 |...|:.||...||:.|:....|........::|..:..|.||||||.:||:||.|:
Human   234 -----PRGVLLAGPPGVGKTQLVRAVAREAGAELLAVSAPALQGSRPGETEENVRRVFQRAR--- 290

  Fly   280 EKLRPLLPIVILIEDLELLCPSTAVADAKNSSNSLRISAELYKLLDAL--PRGIICLATSGVPDS 342
             :|....|.::.:::::.|||...     :.:...|:.|::..|||..  .|.::.:..:..||:
Human   291 -ELASRGPSLLFLDEMDALCPQRG-----SRAPESRVVAQVLTLLDGASGDREVVVVGATNRPDA 349

  Fly   343 LHEHARR--RFVREVTINMPSEGQRRQLVEHLCEVHELNISQTLLEHIARNTQGYVIADLTLLLR 405
            |....||  ||.|||.|..|:..||:::::.:.....:: |...|..:|..|.|||.||||.|.|
Human   350 LDPALRRPGRFDREVVIGTPTLKQRKEILQVITSKMPIS-SHVDLGLLAEMTVGYVGADLTALCR 413

  Fly   406 RVQQQLL-----TKDDFDIEHI-FLKSLSQTQPSASRSTDVRVSKMTAGFEVIGGMEALKRTLQV 464
            ......|     .:|:..|:.| ||::....|||:.||....:......:|.|||:|.:|..|:.
Human   414 EAAMHALLHSEKNQDNPVIDEIDFLEAFKNIQPSSFRSVIGLMDIKPVDWEEIGGLEDVKLKLKQ 478

  Fly   465 SVLAGIRQSAAFARFGLSLPKGVLLYGPPGCAKTTVAKCLAKEADMTFIATSAAEVYSPYVGCAE 529
            |:...::....|.|.||:.||||||||||||||||:.:.||.....:|::.|.|:::||:||.:|
Human   479 SIEWPLKFPWEFVRMGLTQPKGVLLYGPPGCAKTTLVRALATSCHCSFVSVSGADLFSPFVGDSE 543

  Fly   530 RFISRIFDTARKNAPCLIFLDEIDSLVGRRTVSSGGGGGQVQLRILSTLLTEMNGI-------VG 587
            :.:|:||..||.:.|.::|||||||::|.|:.|.  .|..||.|:||.||.|::|:       .|
Human   544 KVLSQIFRQARASTPAILFLDEIDSILGARSASK--TGCDVQERVLSVLLNELDGVGLKTIERRG 606

  Fly   588 GGSQQH---------ILVVAATNRPDMIDDALLRPGRFDKLIHVPAPDEKSRLALLKLHSQRMPF 643
            ..|.|.         ::::|||||||::|.|||||||.||:|::|.||.|.||::||:.::.||.
Human   607 SKSSQQEFQEVFNRSVMIIAATNRPDVLDTALLRPGRLDKIIYIPPPDHKGRLSILKVCTKTMPI 671

  Fly   644 HENVFLQEIAARTDRYSGADLCNLCNEAAIEAFQRD-FKATEIELQDFEKVLTKQKSSLT 702
            ..:|.|:.:||.|..:|||||.|||.|||:.|.|.: ..||.::.:.|.|.|...|.||:
Human   672 GPDVSLENLAAETCFFSGADLRNLCTEAALLALQENGLDATTVKQEHFLKSLKTVKPSLS 731

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG12010	NP_728878.1	CDC48	<220..713	CDD:273521	191/510 (37%)
AFG2B	NP_076968.2	Required for interaction with AFG2A and CINP. /evidence=ECO:0000269|PubMed:38554706	1..189		46/197 (23%)
		CDC48	22..746	CDD:273521	240/754 (32%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	171..203		8/44 (18%)