DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG12010 and SPATA5L1

DIOPT Version :9

Sequence 1:	NP_728878.1	Gene:	CG12010 / 38421	FlyBaseID:	FBgn0035443	Length:	717	Species:	Drosophila melanogaster
Sequence 2:	NP_076968.2	Gene:	SPATA5L1 / 79029	HGNCID:	28762	Length:	753	Species:	Homo sapiens

Alignment Length:	775	Identity:	247/775 - (31%)
Similarity:	377/775 - (48%)	Gaps:	117/775 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MHHNQSDFPTFPLSL---LDDSDLEPQRCYI-PAWENSTGT---GWYRCHLCDGSYAVCWVTPRA 58
            |..:...||..||..   ||..|...|||.: ||..::.|.   ...:..|.||...:|...||.
Human     1 MAPDSDPFPEGPLLKLLPLDARDRGTQRCRLGPAALHALGARLGSAVKISLPDGGSCLCTAWPRR 65

  Fly    59 GS-------ETCCFLDGIVTSLTRFSPTNQRLVLLEPLKLVPC--VKRI---------------- 98
            ..       :..|...|.....:|    ::|.:.|..|.||||  ::|:
Human    66 DGADGFVQLDPLCASPGAAVGASR----SRRSLSLNRLLLVPCPPLRRVAVWPVLRERAGAPGAR 126

  Fly    99 --SCVITVTQELLQRPPVSLEDL---KDDVRIFLRHLKLTKGCS-------VQHRRLVQLGIASV 151
              :.|:...||||:..|:||..:   .......:..|.:..|..       |..|..|.||
Human   127 NTAAVLEAAQELLRNRPISLGHVVVAPPGAPGLVAALHIVGGTPSPDPAGLVTPRTRVSLG---- 187

  Fly   152 EIFDAPGVADDECFEIAHDAELLLADIRLGMPFSLDFIFKY--LPHSFERPMEQLEKLLETSKIS 214
              .:.|..|..:       .|:.|.    |:..:.|.:.:.  ||..:.|.:..|...:
Human   188 --GEPPSEAQPQ-------PEVPLG----GLSEAADSLRELLRLPLRYPRALTALGLAV------ 233

  Fly   215 FSHRFPTTALVVGPVDCGKSGLLSEFLRRHSCNCFYITASQVLRSYPGETEEELRRIFQAAQTFK 279
                 |...|:.||...||:.|:....|........::|..:..|.||||||.:||:||.|:
Human   234 -----PRGVLLAGPPGVGKTQLVRAVAREAGAELLAVSAPALQGSRPGETEENVRRVFQRAR--- 290

  Fly   280 EKLRPLLPIVILIEDLELLCPSTAVADAKNSSNSLRISAELYKLLDAL--PRGIICLATSGVPDS 342
             :|....|.::.:::::.|||...     :.:...|:.|::..|||..  .|.::.:..:..||:
Human   291 -ELASRGPSLLFLDEMDALCPQRG-----SRAPESRVVAQVLTLLDGASGDREVVVVGATNRPDA 349

  Fly   343 LHEHARR--RFVREVTINMPSEGQRRQLVEHLCEVHELNISQTLLEHIARNTQGYVIADLTLLLR 405
            |....||  ||.|||.|..|:..||:::::.:.....:: |...|..:|..|.|||.||||.|.|
Human   350 LDPALRRPGRFDREVVIGTPTLKQRKEILQVITSKMPIS-SHVDLGLLAEMTVGYVGADLTALCR 413

  Fly   406 RVQQQLL-----TKDDFDIEHI-FLKSLSQTQPSASRSTDVRVSKMTAGFEVIGGMEALKRTLQV 464
            ......|     .:|:..|:.| ||::....|||:.||....:......:|.|||:|.:|..|:.
Human   414 EAAMHALLHSEKNQDNPVIDEIDFLEAFKNIQPSSFRSVIGLMDIKPVDWEEIGGLEDVKLKLKQ 478

  Fly   465 SVLAGIRQSAAFARFGLSLPKGVLLYGPPGCAKTTVAKCLAKEADMTFIATSAAEVYSPYVGCAE 529
            |:...::....|.|.||:.||||||||||||||||:.:.||.....:|::.|.|:::||:||.:|
Human   479 SIEWPLKFPWEFVRMGLTQPKGVLLYGPPGCAKTTLVRALATSCHCSFVSVSGADLFSPFVGDSE 543

  Fly   530 RFISRIFDTARKNAPCLIFLDEIDSLVGRRTVSSGGGGGQVQLRILSTLLTEMNGI-------VG 587
            :.:|:||..||.:.|.::|||||||::|.|:.|.  .|..||.|:||.||.|::|:       .|
Human   544 KVLSQIFRQARASTPAILFLDEIDSILGARSASK--TGCDVQERVLSVLLNELDGVGLKTIERRG 606

  Fly   588 GGSQQH---------ILVVAATNRPDMIDDALLRPGRFDKLIHVPAPDEKSRLALLKLHSQRMPF 643
            ..|.|.         ::::|||||||::|.|||||||.||:|::|.||.|.||::||:.::.||.
Human   607 SKSSQQEFQEVFNRSVMIIAATNRPDVLDTALLRPGRLDKIIYIPPPDHKGRLSILKVCTKTMPI 671

  Fly   644 HENVFLQEIAARTDRYSGADLCNLCNEAAIEAFQRD-FKATEIELQDFEKVLTKQKSSLT 702
            ..:|.|:.:||.|..:|||||.|||.|||:.|.|.: ..||.::.:.|.|.|...|.||:
Human   672 GPDVSLENLAAETCFFSGADLRNLCTEAALLALQENGLDATTVKQEHFLKSLKTVKPSLS 731

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG12010	NP_728878.1	SpoVK	201..707	CDD:223540	192/529 (36%)
		AAA	224..357	CDD:278434	41/136 (30%)
		AAA	487..623	CDD:278434	70/151 (46%)
SPATA5L1	NP_076968.2	CDC48	22..746	CDD:273521	240/754 (32%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	171..203		8/44 (18%)
		AAA	237..367	CDD:278434	41/138 (30%)
		AAA	501..651	CDD:278434	70/151 (46%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165160290
Domainoid	1	1.000	139	1.000	Domainoid score	I4804
eggNOG	1	0.900	-	-		E1_COG0464
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S11702
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D169540at33208
OrthoFinder	1	1.000	-	-		FOG0000137
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR23077
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	10	9.760