DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment CG12010 and VCP

DIOPT Version :9

Sequence 1:NP_728878.1 Gene:CG12010 / 38421 FlyBaseID:FBgn0035443 Length:717 Species:Drosophila melanogaster
Sequence 2:NP_009057.1 Gene:VCP / 7415 HGNCID:12666 Length:806 Species:Homo sapiens


Alignment Length:570 Identity:182/570 - (31%)
Similarity:289/570 - (50%) Gaps:79/570 - (13%)


- Green bases have known domain annotations that are detailed below.


  Fly   202 EQLEKLLETSKISFSH---------RFPTTALVVGPVDCGKSGLLSEFLRRHSCNCFYITASQVL 257
            :||.::.|..::...|         :.|...|:.||...||:.:............|.|...:::
Human   211 KQLAQIKEMVELPLRHPALFKAIGVKPPRGILLYGPPGTGKTLIARAVANETGAFFFLINGPEIM 275

  Fly   258 RSYPGETEEELRRIFQAAQTFKEKLRPLLPIVILIEDLELLCPSTAVADAKNSSNSLRISAELYK 322
            ....||:|..||:.|:.|:       ...|.:|.|::|:.:.|.   .:..:.....||.::|..
Human   276 SKLAGESESNLRKAFEEAE-------KNAPAIIFIDELDAIAPK---REKTHGEVERRIVSQLLT 330

  Fly   323 LLDALPR--GIICLATSGVPDSLHEHARR--RFVREVTINMPSEGQRRQLVEHLCEVHELNI--- 380
            |:|.|.:  .:|.:|.:..|:|:....||  ||.|||.|.:|....|.:::    ::|..|:   
Human   331 LMDGLKQRAHVIVMAATNRPNSIDPALRRFGRFDREVDIGIPDATGRLEIL----QIHTKNMKLA 391

  Fly   381 SQTLLEHIARNTQGYVIADLTLLLRRVQQQLLTK--DDFDIE----------------HIFLKSL 427
            ....||.:|..|.|:|.|||..|......|.:.|  |..|:|                ..|..:|
Human   392 DDVDLEQVANETHGHVGADLAALCSEAALQAIRKKMDLIDLEDETIDAEVMNSLAVTMDDFRWAL 456

  Fly   428 SQTQPSASRSTDVRVSKMTAGFEVIGGMEALKRTLQVSVLAGIRQSAAFARFGLSLPKGVLLYGP 492
            ||:.|||.|.|.|.|.::|  :|.|||:|.:||.||..|...:.....|.:||::..||||.|||
Human   457 SQSNPSALRETVVEVPQVT--WEDIGGLEDVKRELQELVQYPVEHPDKFLKFGMTPSKGVLFYGP 519

  Fly   493 PGCAKTTVAKCLAKEADMTFIATSAAEVYSPYVGCAERFISRIFDTARKNAPCLIFLDEIDSLVG 557
            |||.||.:||.:|.|....||:....|:.:.:.|.:|..:..|||.||:.|||::|.||:||:..
Human   520 PGCGKTLLAKAIANECQANFISIKGPELLTMWFGESEANVREIFDKARQAAPCVLFFDELDSIAK 584

  Fly   558 RRTVSSGGGGGQVQLRILSTLLTEMNGIVGGGSQQHILVVAATNRPDMIDDALLRPGRFDKLIHV 622
            .|..:.|.|||... |:::.:||||:|:   .:::::.::.||||||:||.|:|||||.|:||::
Human   585 ARGGNIGDGGGAAD-RVINQILTEMDGM---STKKNVFIIGATNRPDIIDPAILRPGRLDQLIYI 645

  Fly   623 PAPDEKSRLALLKLHSQRMPFHENVFLQEIAARTDRYSGADLCNLC------------------- 668
            |.||||||:|:||.:.::.|..::|.|:.:|..|:.:|||||..:|                   
Human   646 PLPDEKSRVAILKANLRKSPVAKDVDLEFLAKMTNGFSGADLTEICQRACKLAIRESIESEIRRE 710

  Fly   669 -----NEAAIEAFQRDFKATEIELQDFEKVLTKQKSSLTQSQIDGYYKFA 713
                 |.:|:|. :.|....||....||:.:...:.|::.:.|..|..||
Human   711 RERQTNPSAMEV-EEDDPVPEIRRDHFEEAMRFARRSVSDNDIRKYEMFA 759

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG12010NP_728878.1 SpoVK 201..707 CDD:223540 178/562 (32%)
AAA 224..357 CDD:278434 36/136 (26%)
AAA 487..623 CDD:278434 60/135 (44%)
VCPNP_009057.1 CDC48 25..764 CDD:273521 182/570 (32%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 708..727 4/19 (21%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 768..806
Interaction with UBXN6. /evidence=ECO:0000269|PubMed:18656546 797..806
PIM motif. /evidence=ECO:0000269|PubMed:24726327 802..806
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG0464
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D169540at33208
OrthoFinder 1 1.000 - - FOG0000137
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
43.820

Return to query results.
Submit another query.