DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG12010 and Spata5

DIOPT Version :9

Sequence 1:	NP_728878.1	Gene:	CG12010 / 38421	FlyBaseID:	FBgn0035443	Length:	717	Species:	Drosophila melanogaster
Sequence 2:	NP_001156983.1	Gene:	Spata5 / 57815	MGIID:	1927170	Length:	893	Species:	Mus musculus

Alignment Length:	617	Identity:	194/617 - (31%)
Similarity:	297/617 - (48%)	Gaps:	77/617 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly   104 VTQELLQRPPVSLEDLKDDVRIFL---RHLKLTKGCSVQHRRLVQLGIASVEIFDAPGVADDECF 165
            |::|.|.:|..:......|...|:   ..:.|.|.|:....:                   |..|
Mouse   303 VSEEKLLKPASAGTKSNTDTFYFISSTTRINLRKICTNSKEQ-------------------DSQF 348

  Fly   166 EIAHDAELLLADIRLGMPFSLDFIFKYLPHSFERPMEQLEKLLETSKISFSHRFPTTALVVGPVD 230
            ::.:|           |...|:...|.:....|.|::|.|...     |:....|...|:.||..
Mouse   349 KVTYD-----------MIGGLNSQLKAIREIIELPLKQPELFK-----SYGIPAPRGLLLYGPPG 397

  Fly   231 CGKSGLLSEFLRRHSCNCFYITASQVLRSYPGETEEELRRIFQAAQTFKEKLRPLLPIVILIEDL 295
            .||:.:..............|...:::..:.||||..||:|| |..|.:.      |.:|.|::|
Mouse   398 TGKTMIARAVANEVGAYVSVINGPEIISKFYGETEARLRQIF-AEATLRH------PSIIFIDEL 455

  Fly   296 ELLCPSTAVADAKNSSNSLRISAELYKLLDAL----PRG-IICLATSGVPDSLHEHARR--RFVR 353
            :.|||.   .:...|....|:.|.|..|:|.:    ..| ::.|..:..|.:|....||  ||.:
Mouse   456 DALCPK---REGAQSEVEKRVVASLLTLMDGIGSEGSEGRVLVLGATNRPQALDAALRRPGRFDK 517

  Fly   354 EVTINMPSEGQRRQLVEHLCEVHELNISQTLLEHIARNTQGYVIADLTLL--------LRRVQQQ 410
            |:.|.:|:...|..:::.|.......:::..|..:|.|..|||.|||..|        ||||.::
Mouse   518 EIEIGIPNAQDRLDILQKLLRRVPHLLTKAELLRLANNAHGYVGADLKALCNEAGLHALRRVLRK 582

  Fly   411 LLTKDDFDIEHI-------FLKSLSQTQPSASRSTDVRVSKMTAGFEVIGGMEALKRTLQVSVLA 468
            .....|..:..:       ||:.::..:|||.|  :|.:......:..|||:|.:|..|:.:|..
Mouse   583 QPNLPDSKVAGMVKITLNDFLQGMNDIRPSAMR--EVAIDVPNVSWSDIGGLENIKLKLKQAVEW 645

  Fly   469 GIRQSAAFARFGLSLPKGVLLYGPPGCAKTTVAKCLAKEADMTFIATSAAEVYSPYVGCAERFIS 533
            .::...:|.|.|:..||||||||||||:||.:||.||.|:.:.|:|....|:.:.|||.:||.:.
Mouse   646 PLKHPKSFNRMGIQPPKGVLLYGPPGCSKTMIAKALANESGLNFLAIKGPELMNKYVGESERAVR 710

  Fly   534 RIFDTARKNAPCLIFLDEIDSLVGRRTVSSGGGGGQVQLRILSTLLTEMNGIVGGGSQQHILVVA 598
            .||..||..||.:||.||:|:|...|  .|..|.|.|..|:|:.|||||:||   ...:::.|:|
Mouse   711 EIFRKARAVAPSIIFFDELDALAVER--GSSSGAGNVADRVLAQLLTEMDGI---EQLKNVTVLA 770

  Fly   599 ATNRPDMIDDALLRPGRFDKLIHVPAPDEKSRLALLKLHSQRMPFHENVFLQEIAARTDRYSGAD 663
            ||||||.||.||:||||.|::|:||.||..:|..:|.|....||....|.|.|:..:||.||||:
Mouse   771 ATNRPDRIDKALMRPGRIDRIIYVPLPDAATRREILNLQFHSMPISNEVDLDELVLQTDTYSGAE 835

  Fly   664 LCNLCNEAAIEAFQRDFKATEIELQDFEKVLT 695
            :..:|.|||:.|.:.:.||..|..:.|.:.|:
Mouse   836 IIAVCKEAALLALEENIKADCIMKRHFTQALS 867

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG12010	NP_728878.1	SpoVK	201..707	CDD:223540	177/517 (34%)
		AAA	224..357	CDD:278434	38/139 (27%)
		AAA	487..623	CDD:278434	68/135 (50%)
Spata5	NP_001156983.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..38
		CDC48_N	64..132	CDD:304500
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	202..227
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	239..315		4/11 (36%)
		SpoVK	370..882	CDD:223540	179/520 (34%)
		AAA	390..522	CDD:278434	38/141 (27%)
		AAA	664..796	CDD:278434	69/136 (51%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0464
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D169540at33208
OrthoFinder	1	1.000	-	-		FOG0000137
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.820