Protein Alignment CG12010 and PEX6

DIOPT Version :10

• Sequence 1: NP_728878.1
• Gene: CG12010 / 38421
• FlyBaseID: FBgn0035443
• Length: 717
• Species: Drosophila melanogaster
• Sequence 2: NP_000278.3
• Gene: PEX6 / 5190
• HGNCID: 8859
• Length: 980
• Species: Homo sapiens
• Alignment Length: 746
• Identity: 194/746 - (26%)
• Similarity: 322/746 - (43%)
• Gaps: 167/746 - (22%)

  Fly    62 TCCFLDG----------IVTSLTRFSPTNQRLVLLEPLKLVPCVKR--ISCVITVTQ-ELLQRPP 113
            :|..|.|          ||:|....:..|...||....::...|:.  :.||.|:.| |:|:..|
Human   308 SCSLLPGPPFARELHIEIVSSPHYSTNGNYDGVLYRHFQIPRVVQEGDVLCVPTIGQVEILEGSP 372

  Fly   114 VSLEDLKDDVRIFLRHLKLTKGCSVQHRRLVQLGIASVEIFDAP-GVADDECFEIAHDAELLLAD 177
            ..|...::   :|.: :|.|.|                   :|| |.|.....:..|.:..::..
Human   373 EKLPRWRE---MFFK-VKKTVG-------------------EAPDGPASAYLADTTHTSLYMVGS 414

  Fly   178 IRLGMPF----------SLDFIFKYLPHSFERPMEQLEKLLE------------TSKISFSHRFP 220
            ....:|:          ||.      |...|..:.:|..:|:            ||.:
Human   415 TLSPVPWLPSEESTLWSSLS------PPGLEALVSELCAVLKPRLQPGGALLTGTSSV------- 466

  Fly   221 TTALVVGPVDCGKSGLLSEFLRRHSCNCFYITASQVLRSYPGETEEELRRIFQAAQTFKEKLRPL 285
               |:.||..|||:.:::........:...:..|.:.....|..|.:|:.||..|       |..
Human   467 ---LLRGPPGCGKTTVVAAACSHLGLHLLKVPCSSLCAESSGAVETKLQAIFSRA-------RRC 521

  Fly   286 LPIVILIEDLELLCPSTAVADAKNSSNSLRISAELYKL------LDALPRGIICLATSGVPDSLH 344
            .|.|:|:..::||     ..|........|:.|.|..|      |::.|..::...||...| |.
Human   522 RPAVLLLTAVDLL-----GRDRDGLGEDARVMAVLRHLLLNEDPLNSCPPLMVVATTSRAQD-LP 580

  Fly   345 EHARRRFVREVTINMPSEGQR----RQLVEHLCEVHELNISQTLLEHIARNTQGYVIADLTLLLR 405
            ...:..|..|:.:...|||||    |.|..||....|:|::|     :||...|:|:.||..||.
Human   581 ADVQTAFPHELEVPALSEGQRLSILRALTAHLPLGQEVNLAQ-----LARRCAGFVVGDLYALLT 640

  Fly   406 RVQQQL------------LTKDDFD---------IEHIFLKSLSQTQPSASRSTDVRVSKM-TAG 448
            ...:..            ||::|..         :...|.::|.|.|.:.|::  |...|: :..
Human   641 HSSRAACTRIKNSGLAGGLTEEDEGELCAAGFPLLAEDFGQALEQLQTAHSQA--VGAPKIPSVS 703

  Fly   449 FEVIGGMEALKR----TLQVS------VLAGIRQSAAFARFGLSLPKGVLLYGPPGCAKTTVAKC 503
            :..:||::.:|:    |:|:.      :..|:|:|            |:||:||||..||.:||.
Human   704 WHDVGGLQEVKKEILETIQLPLEHPELLSLGLRRS------------GLLLHGPPGTGKTLLAKA 756

  Fly   504 LAKEADMTFIATSAAEVYSPYVGCAERFISRIFDTARKNAPCLIFLDEIDSLVGRRTVSSGGGGG 568
            :|.|..:||::....|:.:.|||.:|..:..:|..||..|||:||.||:|||...|..|...||
Human   757 VATECSLTFLSVKGPELINMYVGQSEENVREVFARARAAAPCIIFFDELDSLAPSRGRSGDSGG- 820

  Fly   569 QVQLRILSTLLTEMNGIVGGGSQQHILVVAATNRPDMIDDALLRPGRFDKLIHVPA-PDEKSRLA 632
             |..|::|.||.|::|:   .|.|.:.|:.||||||::|.|||||||||||:.|.| .|..|:|.
Human   821 -VMDRVVSQLLAELDGL---HSTQDVFVIGATNRPDLLDPALLRPGRFDKLVFVGANEDRASQLR 881

  Fly   633 LLKLHSQRMPFHENVFLQEIA-ARTDRYSGADLCNLCNEAAIEAFQR---DFK--------ATEI 685
            :|...:::.....:|.|..:. ....:.:||||.:||::|...|.:|   |.:        |..:
Human   882 VLSAITRKFKLEPSVSLVNVLDCCPPQLTGADLYSLCSDAMTAALKRRVHDLEEGLEPGSSALML 946

  Fly   686 ELQDFEKVLTKQKSSLTQSQIDGYYKFAYRF 716
            .::|..:...:.:.|:::.::..|.:...:|
Human   947 TMEDLLQAAARLQPSVSEQELLRYKRIQRKF 977

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG12010	NP_728878.1	CDC48	<220..713	CDD:273521	157/547 (29%)
PEX6	NP_000278.3	CDC48	<466..977	CDD:273521	157/557 (28%)