Protein Alignment CG12010 and PEX1

DIOPT Version :10

• Sequence 1: NP_728878.1
• Gene: CG12010 / 38421
• FlyBaseID: FBgn0035443
• Length: 717
• Species: Drosophila melanogaster
• Sequence 2: NP_000457.1
• Gene: PEX1 / 5189
• HGNCID: 8850
• Length: 1283
• Species: Homo sapiens
• Alignment Length: 660
• Identity: 178/660 - (26%)
• Similarity: 300/660 - (45%)
• Gaps: 139/660 - (21%)

  Fly   103 TVTQELLQRPPVSLEDLKDDVRIFLRHLKLTKGCSVQHRRLVQLGIASVEIFDAPGVADDECFEI 167
            |..|.||.  |:..|:..:::...|..|||:....|.     .||::|:|             .|
Human   526 TTIQVLLD--PMVKEENSEEIDFILPFLKLSSLGGVN-----SLGVSSLE-------------HI 570

  Fly   168 AHDAELLLADIRLGMPFSLDFIFKYLPHSFERPMEQLEKLLETSKISFSHRFPTTALVVGPVDCG 232
            .|..        ||.|.|             |.:..|...|....:          |:.|....|
Human   571 THSL--------LGRPLS-------------RQLMSLVAGLRNGAL----------LLTGGKGSG 604

  Fly   233 KSGL-----------LSEFLRRHSCNCFYITASQVLRSYPGETEEELRRIFQAAQTFKEKLRPLL 286
            ||.|           |...:.|..|        :.||   |:..|.:::..:.|  |.|.:. :.
Human   605 KSTLAKAICKEAFDKLDAHVERVDC--------KALR---GKRLENIQKTLEVA--FSEAVW-MQ 655

  Fly   287 PIVILIEDLELLCPSTAVADAKNSSNSLRISAELYKLLDALPRGI------ICLATSGVPDSLH- 344
            |.|:|::||:|:....||.:.::|.::::.....:.|.|.:...|      ..:|||....|||
Human   656 PSVVLLDDLDLIAGLPAVPEHEHSPDAVQSQRLAHALNDMIKEFISMGSLVALIATSQSQQSLHP 720

  Fly   345 --------------EHARRRFVREVTINMPSEGQRRQLVEHL------CEVHELNISQTLLEHIA 389
                          :|          |..|::.||.:::.::      |::::  .:...|:|:|
Human   721 LLVSAQGVHIFQCVQH----------IQPPNQEQRCEILCNVIKNKLDCDINK--FTDLDLQHVA 773

  Fly   390 RNTQGYVIADLTLLLRRV------QQQLLTKDDFDIEHI-FLKSLSQTQPSASRSTDVRVSKMTA 447
            :.|.|:|..|.|:|:.|.      :|.:.|::...:..: |.|:|....|::.||.::...: ..
Human   774 KETGGFVARDFTVLVDRAIHSRLSRQSISTREKLVLTTLDFQKALRGFLPASLRSVNLHKPR-DL 837

  Fly   448 GFEVIGGMEALKRTLQVSVLAGIRQSAAFARFGLSLPKGVLLYGPPGCAKTTVAKCLAKEADMTF 512
            |::.|||:..:::.|..::....:....||...:....|:|||||||..||.:|..:|:|:.|.|
Human   838 GWDKIGGLHEVRQILMDTIQLPAKYPELFANLPIRQRTGILLYGPPGTGKTLLAGVIARESRMNF 902

  Fly   513 IATSAAEVYSPYVGCAERFISRIFDTARKNAPCLIFLDEIDSLVGRRTVSSGGGGGQVQLRILST 577
            |:....|:.|.|:|.:|:.:..||..|:...||::|.||.:|:..||...:.|    |..|:::.
Human   903 ISVKGPELLSKYIGASEQAVRDIFIRAQAAKPCILFFDEFESIAPRRGHDNTG----VTDRVVNQ 963

  Fly   578 LLTEMNGIVGGGSQQHILVVAATNRPDMIDDALLRPGRFDKLIHVPAPDEKSRLALLKLHSQRMP 642
            |||:::|:.|   .|.:.|:|||:|||:||.|||||||.||.::.|.||:.|||.:|.:.|..:|
Human   964 LLTQLDGVEG---LQGVYVLAATSRPDLIDPALLRPGRLDKCVYCPPPDQVSRLEILNVLSDSLP 1025

  Fly   643 FHENVFLQEIAARTDRYSGADLCNLCNEAAIEA---------FQRDFKATEIELQDFEKVLTKQK 698
            ..::|.||.:|:.||.::||||..|...|.:||         .|....:::.:|.....|.....
Human  1026 LADDVDLQHVASVTDSFTGADLKALLYNAQLEALHGMLLSSGLQDGSSSSDSDLSLSSMVFLNHS 1090

  Fly   699 SSLTQSQIDG 708
            |....|..||
Human  1091 SGSDDSAGDG 1100

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG12010	NP_728878.1	CDC48	<220..713	CDD:273521	154/543 (28%)
PEX1	NP_000457.1	PEX-2N	17..98	CDD:462730
		PEX-1N	104..179	CDD:462729
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	346..367
		CDC48	<595..1065	CDD:273521	147/513 (29%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1260..1283