Protein Alignment CG12010 and Pex1

DIOPT Version :10

• Sequence 1: NP_728878.1
• Gene: CG12010 / 38421
• FlyBaseID: FBgn0035443
• Length: 717
• Species: Drosophila melanogaster
• Sequence 2: NP_001102690.1
• Gene: Pex1 / 500006
• RGDID: 1559939
• Length: 1283
• Species: Rattus norvegicus
• Alignment Length: 698
• Identity: 188/698 - (26%)
• Similarity: 325/698 - (46%)
• Gaps: 132/698 - (18%)

  Fly    49 YAVCWVTPRAGSETCCFLDGIVTSLTRFSPTNQRLVLLEPLKLVPCVKRISCVITVTQELLQRPP 113
            :||..:||   .||              :|...|.:.|:|.:.:|.......|..|....||...
  Rat   426 HAVVRITP---LET--------------TPVIPRALRLQPAENLPRDVSEEEVKAVFSSWLQESA 473

  Fly   114 VSL--------EDLKDDVRIFLRHLKLT----------KGCSVQHRRLVQLGIASVEIFDAPGVA 160
            .::        |.:|.:::..|:...|:          :|.:|.....:.|...||::...|.:.
  Rat   474 TTMFPLIISKQECIKLEIKDGLKEFSLSIVHSQEKEKEQGRTVFVLSPILLQKISVQVLLEPMIG 538

  Fly   161 DDECFEIAHDAELLLADI---RLGMPFSLDF-IFKYLPHS-FERPM-EQLEKLLETSKISFSHRF 219
                 |.:.:.::||..:   .||...||.. ..:::.|| ..||: .||..|:...:..
  Rat   539 -----EHSEEIDILLPSLTLSSLGGVSSLSVSAMEHITHSLLGRPLSRQLMALVAGLRNG----- 593

  Fly   220 PTTALVVGPVDCGKSGLLSEFLRR-HSC--------NCFYITASQVLRSYPGETEEELRRIFQAA 275
              ..|:.|....|||.|.....:. |..        :|      :.||   |:..|.:::..:.|
  Rat   594 --ALLITGGKGSGKSTLAKAICKEAHDALDAHVEMVDC------KALR---GKRLESIQKALEVA 647

  Fly   276 QTFKEKL-RPLLPIVILIEDLELLC--PSTAVAD-AKNSSNSLRISAELYKLL-DALPRG--IIC 333
              |.|.. |.  |.|||::||:|:.  |||...: :..:..|.|::..|..:: :.:..|  :..
  Rat   648 --FSEAAWRQ--PSVILLDDLDLIAGLPSTPEHEHSPEAVQSQRLAHALNNMIKEFVSMGSLVAL 708

  Fly   334 LATSGVPDSLH---------------EHARRRFVREVTINMPSEGQRRQLVEHL------CEVHE 377
            :|||.:..|||               :|          |..|.:.||.:::..:      |::.:
  Rat   709 IATSQLQHSLHPSLVSAQGVHTFQCIQH----------IQPPDQEQRCEILHSVVKNKLGCDISK 763

  Fly   378 LNISQTL-LEHIARNTQGYVIADLTLLLRRV------QQQLLTKDDFDIEHI-FLKSLSQTQPSA 434
               |..| |:.||:.|:.:|..|.|:|:.|.      :||..|::...:... |.|:|....|::
  Rat   764 ---SPDLDLKCIAKETEAFVARDFTVLVDRAIHSSLSRQQNPTREGLTLTTADFQKALRGFLPAS 825

  Fly   435 SRSTDVRVSKMTAGFEVIGGMEALKRTLQVSVLAGIRQSAAFARFGLSLPKGVLLYGPPGCAKTT 499
            .|:.::...: ..|::.|||:..:::.|..::....:....||...:....|:|||||||..||.
  Rat   826 LRNVNLHKPR-DLGWDKIGGLHEVRQILMDTIQLPAKYPELFANLPIRQRTGILLYGPPGTGKTL 889

  Fly   500 VAKCLAKEADMTFIATSAAEVYSPYVGCAERFISRIFDTARKNAPCLIFLDEIDSLVGRRTVSSG 564
            :|..:|:|:.|.||:....|:.|.|:|.:|:.:..:|..|:...||::|.||.:|:..||...:.
  Rat   890 LAGVVARESGMNFISIQGPELLSKYIGASEQAVRDVFIRAQAAKPCILFFDEFESIAPRRGHDNT 954

  Fly   565 GGGGQVQLRILSTLLTEMNGIVGGGSQQHILVVAATNRPDMIDDALLRPGRFDKLIHVPAPDEKS 629
            |    |..|:::.|||:::|:.|   .|.:.|:|||:|||:||.|||||||.||.::.|.||:.|
  Rat   955 G----VTDRVVNQLLTQLDGVEG---LQGVYVLAATSRPDLIDPALLRPGRLDKCVYCPPPDQVS 1012

  Fly   630 RLALLKLHSQRMPFHENVFLQEIAARTDRYSGADLCNLCNEAAIEAFQ 677
            ||.:|.:.|:.:|..::|.||.:|:.|:.::||||..|...|.:||.|
  Rat  1013 RLEILTVLSKSLPLADDVDLQHVASVTESFTGADLKALLYNAQLEALQ 1060

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG12010	NP_728878.1	CDC48	<220..713	CDD:273521	149/503 (30%)
Pex1	NP_001102690.1	PEX-2N	17..98	CDD:462730
		PEX-1N	104..179	CDD:462729
		NACHT	418..>750	CDD:444362	80/375 (21%)
		CDC48	<595..1060	CDD:273521	148/498 (30%)