Protein Alignment CG12010 and NVL

DIOPT Version :10

• Sequence 1: NP_728878.1
• Gene: CG12010 / 38421
• FlyBaseID: FBgn0035443
• Length: 717
• Species: Drosophila melanogaster
• Sequence 2: XP_016856867.1
• Gene: NVL / 4931
• HGNCID: 8070
• Length: 917
• Species: Homo sapiens
• Alignment Length: 773
• Identity: 212/773 - (27%)
• Similarity: 339/773 - (43%)
• Gaps: 192/773 - (24%)

  Fly    71 TSLTRFSPTNQRLVLLEPLK---------LVPCVKRISCVITVTQELL--QRPPVSLEDLKD--- 121
            :|..|.|.....:.|..|.|         ..|.||:.|..:.::.|..  ::|...::|.||
Human   182 SSTPRISSKTGSIPLKTPAKDSEGGWFIDKTPSVKKDSFFLDLSCEKSNPKKPITEIQDSKDSSL 246

  Fly   122 ---DVRIFLRHLKLTKGCSVQHRRLVQLGIASVEIFDAPGVADDECFEIAHDAELLL---ADIRL 180
               |::   |..||....|.:.:..:|                    |:..:.|.:|   |..|
Human   247 LESDMK---RKGKLKNKGSKRKKEDLQ--------------------EVDGEIEAVLQKKAKAR- 287

  Fly   181 GMPFSLDFIFKYLPHSFERPMEQLEKLLETSKISFSHRFPTT-----------ALVVGPVDCGKS 234
            |:.|.:..:      .||........|.|..|:....|.|..           .|:.||..|||:
Human   288 GLEFQISNV------KFEDVGGNDMTLKEVCKMLIHMRHPEVYHHLGVVPPRGVLLHGPPGCGKT 346

  Fly   235 GLLSEFLRRHSC------NCFY----------------------ITASQVLRSYPGETEEELRRI 271
             ||:..:....|      :|.:                      :.|.:::....||:|::||.:
Human   347 -LLAHAIAGAECSGMITAHCSFDFSGSNDPPASASQELDLPILKVAAPEIVSGVSGESEQKLREL 410

  Fly   272 FQAAQTFKEKLRPLLPIVILIEDLELLCPSTAVADAKNSSNSLRISAELYKLLD-----ALPRGI 331
            |:.|.:       ..|.:|.|::::.:.|...||   :.....||.|:|...:|     |....:
Human   411 FEQAVS-------NAPCIIFIDEIDAITPKREVA---SKDMERRIVAQLLTCMDDLNNVAATARV 465

  Fly   332 ICLATSGVPDSLHEHARR--RFVREVTINMPSEGQRRQLVEHLCEVHELNISQTL-LEHIARNTQ 393
            :.:..:..||||....||  ||.||:.:.:|.|..|.::::.||  .:|.:.|.. ..|:|..|.
Human   466 LVIGATNRPDSLDPALRRAGRFDREICLGIPDEASRERILQTLC--RKLRLPQAFDFCHLAHLTP 528

  Fly   394 GYVIADLTLLLRR------------------------------VQQQLL-------TKDDFD--- 418
            |:|.|||..|.|.                              ||::.|       |:|:..
Human   529 GFVGADLMALCREAAMCAVNRVLMKLQEQQKKNPEMEDLPSKGVQEERLGTEPTSETQDELQRLL 593

  Fly   419 ------------------IE-HIFLKSLSQTQPSASRSTDVRVSKMTAGFEVIGGMEALKRTLQV 464
                              || :.|:.:||..||||.|...|.|..:|  :..||.:|.::..|.:
Human   594 GLLRDQDPLSEEQMQGLCIELNDFIVALSSVQPSAKREGFVTVPNVT--WADIGALEDIREELTM 656

  Fly   465 SVLAGIRQSAAFARFGLSLPKGVLLYGPPGCAKTTVAKCLAKEADMTFIATSAAEVYSPYVGCAE 529
            ::||.:|....|...||..|.||||.|||||.||.:||.:|.|:.:.||:....|:.:.|||.:|
Human   657 AILAPVRNPDQFKALGLVTPAGVLLAGPPGCGKTLLAKAVANESGLNFISVKGPELLNMYVGESE 721

  Fly   530 RFISRIFDTARKNAPCLIFLDEIDSLVGRRTVSSGGGGGQVQLRILSTLLTEMNGIVGGGSQQHI 594
            |.:.::|..|:.:|||:||.||:|:|..||:....|    ..:|:::.|||||:|:   .::|.:
Human   722 RAVRQVFQRAKNSAPCVIFFDEVDALCPRRSDRETG----ASVRVVNQLLTEMDGL---EARQQV 779

  Fly   595 LVVAATNRPDMIDDALLRPGRFDKLIHVPAPDEKSRLALLKL---HSQRMPFHENVFLQEIAA-- 654
            .::|||||||:||.|:|||||.||.:.|..|....|||:||.   :..:.|...:|.|:.||.
Human   780 FIMAATNRPDIIDPAILRPGRLDKTLFVGLPPPADRLAILKTITKNGTKPPLDADVNLEAIAGDL 844

  Fly   655 RTDRYSGADLCNLCNEAAIEAFQRDFK---------ATEIELQDFEKVLTKQKSSLTQ 703
            |.|.|:||||..|..||:|.|.:::..         ..::..:.||:...|.:||:::
Human   845 RCDCYTGADLSALVREASICALRQEMARQKSGNEKGELKVSHKHFEEAFKKVRSSISK 902

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG12010	NP_728878.1	CDC48	<220..713	CDD:273521	178/604 (29%)
NVL	XP_016856867.1	Nucleolin_bd	2..72	CDD:465247
		CDC48	<277..917	CDD:273521	190/655 (29%)