Protein Alignment CG12010 and Spast

DIOPT Version :10

• Sequence 1: NP_728878.1
• Gene: CG12010 / 38421
• FlyBaseID: FBgn0035443
• Length: 717
• Species: Drosophila melanogaster
• Sequence 2: XP_008762708.1
• Gene: Spast / 362700
• RGDID: 1308494
• Length: 614
• Species: Rattus norvegicus
• Alignment Length: 532
• Identity: 141/532 - (26%)
• Similarity: 228/532 - (42%)
• Gaps: 113/532 - (21%)

  Fly   261 PGETEEELRRIFQAAQTFKEKLRPLLPIVILIEDLELLCPSTAVADAKNSSNSLRISAELYKL-L 324
            ||...|.:|       .|.::....:.|.:.|             |.:..:.....:.|.||. :
  Rat   107 PGGEAESVR-------VFHKQAFEYISIALRI-------------DEEEKAGQKEQAVEWYKKGI 151

  Fly   325 DALPRGIICLATSGVPDSLHEHARRRFVREVTINMPSEGQRRQLVEHLCEVHELNISQTLLEHIA 389
            :.|.:||..:.|.  ....:|.|||...:.:| |:.....|.||:|.|..|.:.:.|||.:.:.:
  Rat   152 EELEKGIAVIVTG--QGEQYERARRLQAKMMT-NLVMAKDRLQLLEKLQPVLQFSKSQTDVYNES 213

  Fly   390 RN---TQGYVIADLTLLLRRVQQQLLTKDDFDIEHIFLKSLS----------------------- 428
            .|   ..|::.::...:.::........:........:||.|
  Rat   214 TNLTCRNGHLQSESGAVPKKKDPLTHASNSLPRSKTVMKSGSTGLSGHHRAPSCSGLSMVSGARP 278

  Fly   429 ----------------QTQPSASRSTDVRVSK------------------------MTAGFEVIG 453
                            :|...::.:|.||..|                        ....|:.|.
  Rat   279 GSGPAATTHKGTSKPNRTNKPSTPTTAVRKKKDLKNFRNVDSNLANLIMNEIVDNGTAVKFDDIA 343

  Fly   454 GMEALKRTLQVSVLAGIRQSAAFARFGLSLP-KGVLLYGPPGCAKTTVAKCLAKEADMTFIATSA 517
            |.|..|:.||..|:....:...|.  ||..| :|:||:||||..||.:||.:|.|::.||...||
  Rat   344 GQELAKQALQEIVILPSLRPELFT--GLRAPARGLLLFGPPGNGKTMLAKAVAAESNATFFNISA 406

  Fly   518 AEVYSPYVGCAERFISRIFDTARKNAPCLIFLDEIDSLVGRRTVSSGGGGGQVQLRILSTLLTEM 582
            |.:.|.|||..|:.:..:|..||:..|.:||:||:|||:..|.    .|......|:.:..|.|.
  Rat   407 ASLTSKYVGEGEKLVRALFAVARELQPSIIFIDEVDSLLCERR----EGEHDASRRLKTEFLIEF 467

  Fly   583 NGIVGGGSQQHILVVAATNRPDMIDDALLRPGRFDKLIHVPAPDEKSRLALLK--LHSQRMPFHE 645
            :|:...|..: :||:.|||||..:|:|:||  ||.|.::|..|:|::||.|||  |..|..|..:
  Rat   468 DGVQSAGDDR-VLVMGATNRPQELDEAVLR--RFIKRVYVSLPNEETRLLLLKNLLCKQGSPLTQ 529

  Fly   646 NVFLQEIAARTDRYSGADLCNLCNEAAIEAFQ-------RDFKATE---IELQDFEKVLTKQKSS 700
            .. |.::|..||.|||:||..|..:||:...:       ::..|:|   |.|.||.:.|.|.|.|
  Rat   530 KE-LAQLARMTDGYSGSDLTALAKDAALGPIRELKPEQVKNMSASEMRNIRLSDFTESLKKIKRS 593

  Fly   701 LTQSQIDGYYKF 712
            ::...::.|.::
  Rat   594 VSPQTLEAYIRW 605

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG12010	NP_728878.1	CDC48	<220..713	CDD:273521	141/532 (27%)
Spast	XP_008762708.1	MIT_spastin	114..193	CDD:239142	20/101 (20%)
		RecA-like_spastin	341..504	CDD:410932	66/171 (39%)
		AAA_lid_3	531..585	CDD:465537	18/54 (33%)
		Vps4_C	<578..610	CDD:462762	9/28 (32%)