DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG12010 and TER94

DIOPT Version :9

Sequence 1:	NP_728878.1	Gene:	CG12010 / 38421	FlyBaseID:	FBgn0035443	Length:	717	Species:	Drosophila melanogaster
Sequence 2:	NP_001097249.1	Gene:	TER94 / 36040	FlyBaseID:	FBgn0286784	Length:	826	Species:	Drosophila melanogaster

Alignment Length:	570	Identity:	176/570 - (30%)
Similarity:	285/570 - (50%)	Gaps:	78/570 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly   202 EQLEKLLETSKISFSH---------RFPTTALVVGPVDCGKSGLLSEFLRRHSCNCFYITASQVL 257
            :||.::.|..::...|         :.|...|:.||...||:.:............|.|...:::
  Fly   233 KQLAQIKEMVELPLRHPSLFKAIGVKPPRGILMYGPPGTGKTLIARAVANETGAFFFLINGPEIM 297

  Fly   258 RSYPGETEEELRRIFQAAQTFKEKLRPLLPIVILIEDLELLCPSTAVADAKNSSNSLRISAELYK 322
            ....||:|..||:.|:.|:...       |.:|.|::::.:.|.   .|..:.....||.::|..
  Fly   298 SKLAGESESNLRKAFEEAEKNS-------PAIIFIDEIDAIAPK---RDKTHGEVERRIVSQLLT 352

  Fly   323 LLDALPRG--IICLATSGVPDSLHEHARR--RFVREVTINMPSEGQRRQLVEHLCEVHELNI--- 380
            |:|.:.:.  :|.:|.:..|:|:....||  ||.||:.|.:|....|.:::    .:|..|:
  Fly   353 LMDGMKKSSHLIVMAATNRPNSIDPALRRFGRFDREIDIGIPDATGRLEVL----RIHTKNMKLH 413

  Fly   381 SQTLLEHIARNTQGYVIADLTLL-----LRRVQQQL----LTKDDFDIEHI---------FLKSL 427
            ....||.||..:.|:|.|||..|     |:::::::    |..|..|.|.:         |..::
  Fly   414 DDVDLEQIAAESHGHVGADLASLCSEAALQQIREKMDLIDLEDDKIDAEVLASLAVTMENFRYAM 478

  Fly   428 SQTQPSASRSTDVRVSKMTAGFEVIGGMEALKRTLQVSVLAGIRQSAAFARFGLSLPKGVLLYGP 492
            :::.|||.|.|.|.|...|  :..|||:|::|:.||..|...:.....|.:||:...:|||.|||
  Fly   479 TKSSPSALRETVVEVPNTT--WTDIGGLESVKKELQELVQYPVEHPDKFLKFGMQPSRGVLFYGP 541

  Fly   493 PGCAKTTVAKCLAKEADMTFIATSAAEVYSPYVGCAERFISRIFDTARKNAPCLIFLDEIDSLVG 557
            |||.||.:||.:|.|....||:....|:.:.:.|.:|..:..|||.||..|||::|.||:||:..
  Fly   542 PGCGKTLLAKAIANECQANFISVKGPELLTMWFGESEANVRDIFDKARSAAPCVLFFDELDSIAK 606

  Fly   558 RRTVSSGGGGGQVQLRILSTLLTEMNGIVGGGSQQHILVVAATNRPDMIDDALLRPGRFDKLIHV 622
            .|..:.|..||... |:::.:||||:|:   |:::::.::.||||||:||.|:|||||.|:||::
  Fly   607 ARGGNVGDAGGAAD-RVINQILTEMDGM---GAKKNVFIIGATNRPDIIDPAILRPGRLDQLIYI 667

  Fly   623 PAPDEKSRLALLKLHSQRMPFHENVFLQEIAARTDRYSGADLCNLCNEA-------AIEA----- 675
            |.||:|||.|:||.:.::.|..:.|.|..||..|..:|||||..:|..|       ||||
  Fly   668 PLPDDKSREAILKANLRKSPLAKEVDLTYIAKVTQGFSGADLTEICQRACKLAIRQAIEAEIRRE 732

  Fly   676 ------------FQRDFKATEIELQDFEKVLTKQKSSLTQSQIDGYYKFA 713
                        ...|....||....||:.:...:.|::.:.|..|..||
  Fly   733 KERAENQNSAMDMDEDDPVPEITSAHFEEAMKFARRSVSDNDIRKYEMFA 782

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG12010	NP_728878.1	SpoVK	201..707	CDD:223540	172/562 (31%)
		AAA	224..357	CDD:278434	34/136 (25%)
		AAA	487..623	CDD:278434	60/135 (44%)
TER94	NP_001097249.1	CDC48	47..787	CDD:273521	176/570 (31%)
		CDC48_N	47..129	CDD:280513
		CDC48_2	153..213	CDD:215011
		AAA	263..392	CDD:278434	34/138 (25%)
		AAA	536..669	CDD:278434	60/136 (44%)
		Vps4_C	<741..783	CDD:286426	10/42 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45445207
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0464
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D169540at33208
OrthoFinder	1	1.000	-	-		FOG0000137
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR23077
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	6	5.850