Protein Alignment CG12010 and Vcp

DIOPT Version :10

• Sequence 1: NP_728878.1
• Gene: CG12010 / 38421
• FlyBaseID: FBgn0035443
• Length: 717
• Species: Drosophila melanogaster
• Sequence 2: NP_033529.3
• Gene: Vcp / 269523
• MGIID: 99919
• Length: 806
• Species: Mus musculus
• Alignment Length: 570
• Identity: 182/570 - (31%)
• Similarity: 289/570 - (50%)
• Gaps: 79/570 - (13%)

  Fly   202 EQLEKLLETSKISFSH---------RFPTTALVVGPVDCGKSGLLSEFLRRHSCNCFYITASQVL 257
            :||.::.|..::...|         :.|...|:.||...||:.:............|.|...:::
Mouse   211 KQLAQIKEMVELPLRHPALFKAIGVKPPRGILLYGPPGTGKTLIARAVANETGAFFFLINGPEIM 275

  Fly   258 RSYPGETEEELRRIFQAAQTFKEKLRPLLPIVILIEDLELLCPSTAVADAKNSSNSLRISAELYK 322
            ....||:|..||:.|:.|:       ...|.:|.|::|:.:.|.   .:..:.....||.::|..
Mouse   276 SKLAGESESNLRKAFEEAE-------KNAPAIIFIDELDAIAPK---REKTHGEVERRIVSQLLT 330

  Fly   323 LLDALPR--GIICLATSGVPDSLHEHARR--RFVREVTINMPSEGQRRQLVEHLCEVHELNI--- 380
            |:|.|.:  .:|.:|.:..|:|:....||  ||.|||.|.:|....|.:::    ::|..|:
Mouse   331 LMDGLKQRAHVIVMAATNRPNSIDPALRRFGRFDREVDIGIPDATGRLEIL----QIHTKNMKLA 391

  Fly   381 SQTLLEHIARNTQGYVIADLTLLLRRVQQQLLTK--DDFDIE----------------HIFLKSL 427
            ....||.:|..|.|:|.|||..|......|.:.|  |..|:|                ..|..:|
Mouse   392 DDVDLEQVANETHGHVGADLAALCSEAALQAIRKKMDLIDLEDETIDAEVMNSLAVTMDDFRWAL 456

  Fly   428 SQTQPSASRSTDVRVSKMTAGFEVIGGMEALKRTLQVSVLAGIRQSAAFARFGLSLPKGVLLYGP 492
            ||:.|||.|.|.|.|.::|  :|.|||:|.:||.||..|...:.....|.:||::..||||.|||
Mouse   457 SQSNPSALRETVVEVPQVT--WEDIGGLEDVKRELQELVQYPVEHPDKFLKFGMTPSKGVLFYGP 519

  Fly   493 PGCAKTTVAKCLAKEADMTFIATSAAEVYSPYVGCAERFISRIFDTARKNAPCLIFLDEIDSLVG 557
            |||.||.:||.:|.|....||:....|:.:.:.|.:|..:..|||.||:.|||::|.||:||:..
Mouse   520 PGCGKTLLAKAIANECQANFISIKGPELLTMWFGESEANVREIFDKARQAAPCVLFFDELDSIAK 584

  Fly   558 RRTVSSGGGGGQVQLRILSTLLTEMNGIVGGGSQQHILVVAATNRPDMIDDALLRPGRFDKLIHV 622
            .|..:.|.|||... |:::.:||||:|:   .:::::.::.||||||:||.|:|||||.|:||::
Mouse   585 ARGGNIGDGGGAAD-RVINQILTEMDGM---STKKNVFIIGATNRPDIIDPAILRPGRLDQLIYI 645

  Fly   623 PAPDEKSRLALLKLHSQRMPFHENVFLQEIAARTDRYSGADLCNLC------------------- 668
            |.||||||:|:||.:.::.|..::|.|:.:|..|:.:|||||..:|
Mouse   646 PLPDEKSRVAILKANLRKSPVAKDVDLEFLAKMTNGFSGADLTEICQRACKLAIRESIESEIRRE 710

  Fly   669 -----NEAAIEAFQRDFKATEIELQDFEKVLTKQKSSLTQSQIDGYYKFA 713
                 |.:|:|. :.|....||....||:.:...:.|::.:.|..|..||
Mouse   711 RERQTNPSAMEV-EEDDPVPEIRRDHFEEAMRFARRSVSDNDIRKYEMFA 759

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG12010	NP_728878.1	CDC48	<220..713	CDD:273521	176/541 (33%)
Vcp	NP_033529.3	CDC48	25..764	CDD:273521	182/570 (32%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	708..727		4/19 (21%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	768..806
		Interaction with UBXN6. /evidence=ECO:0000250	797..806
		PIM motif. /evidence=ECO:0000250|UniProtKB:P55072	802..806