Protein Alignment CG12010 and prx-1

DIOPT Version :10

• Sequence 1: NP_728878.1
• Gene: CG12010 / 38421
• FlyBaseID: FBgn0035443
• Length: 717
• Species: Drosophila melanogaster
• Sequence 2: NP_510386.2
• Gene: prx-1 / 181538
• WormBaseID: WBGene00004191
• Length: 996
• Species: Caenorhabditis elegans
• Alignment Length: 654
• Identity: 156/654 - (23%)
• Similarity: 288/654 - (44%)
• Gaps: 111/654 - (16%)

  Fly    89 LKLVP----CVKRI---SC-VITVTQELLQRPPVSLEDLKD---DVRIFLRHLKLTKGCSVQHRR 142
            ||:||    .|||:   :| :..:|.||:.:   .|.|||.   |.....|..|.|:...
 Worm   399 LKVVPSMKGLVKRVTENTCFLFDLTTELIFQ---QLGDLKQKHGDTENTRRRRKRTEEAE----- 455

  Fly   143 LVQLGIASVEIFDAPGVADDECFEIAHDAELLLADIRLGMPFSLDFIFKYLPHSFERPMEQLEKL 207
                  ||.:|...|..:..|.|..|.:...    :::|              |..:.:.:|:|:
 Worm   456 ------ASEQIPQKPETSTMENFGFAQNKHF----VQIG--------------SHSKLLSELDKV 496

  Fly   208 LETSKISFSHRFPTTALVVGPVDCGKSGLLSEFLRRHSCN-----CFYITASQVLRSYPGETEEE 267
            ....|   .|     .:|:|....||:..:.:..||.|.|     |..:..: :|:....:..|:
 Worm   497 CCGGK---QH-----VMVLGGNGSGKTTFIKKLARRLSHNSSVTFCKMVPCA-LLKGRSADIIEK 552

  Fly   268 LRRIFQAAQTFKEKLRPLLPIVILIEDLELLCPSTAVADAKNSSNSL-RISAELYKLLDALPRGI 331
            |     .:.|..| :....|..:.::|.:::.|.   .|.:....:: ::.:...:.|......:
 Worm   553 L-----LSDTLHE-MEVKKPSCLFLDDFDVILPQ---IDQEQRHLAMEKVVSVFAQKLRTTEVSV 608

  Fly   332 ICLA--TSGVPDSLHEHARRRFVREVTINMPSEGQRRQL----VEHLCEVHE----LNISQTLLE 386
            :.:|  .|.:.|.        ||.:|....|...::.:|    .|..||:.|    |..:..::.
 Worm   609 VLVAQRLSSLNDG--------FVEQVMRARPIVSRKIELEQLTKEDRCEIFETFLDLPENSDIIS 665

  Fly   387 HIARNTQGYVIADLTLLLRRVQQQLLTK-----DDFDIEHIFLKSLSQTQPSASRSTDVRVSKMT 446
            .|.:.:.||..:::..|...:..:...|     .:.::|..|...:      |.:...:...::.
 Worm   666 EIVKKSDGYTFSEIEKLAVSINVECAIKGVKYITEIEVEKAFECFV------AGKMGKIEDGQVL 724

  Fly   447 AGFEVIGGMEALKRTLQVSVLAGIRQSAAFARFGLSLPKGVLLYGPPGCAKTTVAKCLAKEADMT 511
            ...|.:|||...|:.|:..::...:....|...|:.:.||:||:||.||.||.:|......::.:
 Worm   725 PTMEDVGGMFEQKKLLEQVIIWPRKYPQLFESVGVPVSKGILLHGPSGCGKTLLANATISNSNFS 789

  Fly   512 FIATSAAEVYSPYVGCAERFISRIFDTARKNAPCLIFLDEIDSLVGRRTVSSGGGGGQVQLRILS 576
            .:.....|:.|.|:|.:|..:..:|:.||..|||::|.||:|||..:|...|.|    |..|:::
 Worm   790 VVNVKGPELLSKYIGASEENVRLVFEKARSCAPCILFFDELDSLAPKRGHDSTG----VTDRVVN 850

  Fly   577 TLLTEMNGIVGGGSQQHILVVAATNRPDMIDDALLRPGRFDKLIHVPAPDEKSRLALLKLHSQRM 641
            .||||::|..||  .:.::::..|:|.|:||||||||||||..::...|::..||.::|:.:.::
 Worm   851 QLLTELDGAEGG--MKGVIILGCTSRIDLIDDALLRPGRFDHHVYCGHPEKTERLDIMKVLTNKL 913

  Fly   642 PFHENVFLQEIAARTDRYSGADLCNLCNEAAIEAFQRDFKATEIELQDFEKVLTKQKSSLTQSQI 706
            . ..:|..:.:|.:||.:|||||..|...|..      :.|.:|..:  |..|.:....:.|:.|
 Worm   914 K-PTDVDFECLAQKTDGWSGADLQLLFTNAQF------YNARQIAKE--EDGLEEDNVPIDQASI 969

  Fly   707 DGYY 710
            :..:
 Worm   970 ESVF 973

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG12010	NP_728878.1	CDC48	<220..713	CDD:273521	124/512 (24%)
prx-1	NP_510386.2	PEX-1N	103..179	CDD:462729
		P-loop containing Nucleoside Triphosphate Hydrolases	481..>522	CDD:476819	10/62 (16%)
		CDC48	<504..952	CDD:273521	120/484 (25%)
		RecA-like_PEX1_r2	736..894	CDD:410934	59/163 (36%)