Protein Alignment CG12010 and AFG2A

DIOPT Version :10

• Sequence 1: NP_728878.1
• Gene: CG12010 / 38421
• FlyBaseID: FBgn0035443
• Length: 717
• Species: Drosophila melanogaster
• Sequence 2: NP_001425251.1
• Gene: AFG2A / 166378
• HGNCID: 18119
• Length: 917
• Species: Homo sapiens
• Alignment Length: 589
• Identity: 182/589 - (30%)
• Similarity: 285/589 - (48%)
• Gaps: 79/589 - (13%)

  Fly   162 DECFEIAHDAELLLADIRLGMPFSLDFIFKYLPHSFERPMEQLEKLLETSKISFSHRFPTTALVV 226
            |..|::.:|           |...|....|.:....|.|::|.|...     |:....|...|:.
Human   345 DNQFKVTYD-----------MIGGLSSQLKAIREIIELPLKQPELFK-----SYGIPAPRGVLLY 393

  Fly   227 GPVDCGKSGLLSEFLRRHSCNCFYITASQVLRSYPGETEEELRRIFQAAQTFKEKLRPLLPIVIL 291
            ||...||:.:..............|...:::..:.||||.:||:|| |..|.:.      |.:|.
Human   394 GPPGTGKTMIARAVANEVGAYVSVINGPEIISKFYGETEAKLRQIF-AEATLRH------PSIIF 451

  Fly   292 IEDLELLCPSTAVADAKNSSNSLRISAELYKLLDAL----PRG-IICLATSGVPDSLHEHARR-- 349
            |::|:.|||..  ..|:|.... |:.|.|..|:|.:    ..| ::.|..:..|.:|....||
Human   452 IDELDALCPKR--EGAQNEVEK-RVVASLLTLMDGIGSEVSEGQVLVLGATNRPHALDAALRRPG 513

  Fly   350 RFVREVTINMPSEGQRRQLVEHLCEVHELNISQTLLEHIARNTQGYVIADLTLL----------- 403
            ||.:|:.|.:|:...|..:::.|.......:::..|..:|.:..|||.|||.:|
Human   514 RFDKEIEIGVPNAQDRLDILQKLLRRVPHLLTEAELLQLANSAHGYVGADLKVLCNEAAGTRILK 578

  Fly   404 ---------------------LRRVQQQLLTKDDFDIEHI-------FLKSLSQTQPSASRSTDV 440
                                 |||:.::.....|..:..:       ||::::..:|||.|  ::
Human   579 AHMYVSAFATGLTQTPQGLCALRRILKKQPNLPDVKVAGLVKITLKDFLQAMNDIRPSAMR--EI 641

  Fly   441 RVSKMTAGFEVIGGMEALKRTLQVSVLAGIRQSAAFARFGLSLPKGVLLYGPPGCAKTTVAKCLA 505
            .:......:..|||:|::|..|:.:|...::...:|.|.|:..||||||||||||:||.:||.||
Human   642 AIDVPNVSWSDIGGLESIKLKLEQAVEWPLKHPESFIRMGIQPPKGVLLYGPPGCSKTMIAKALA 706

  Fly   506 KEADMTFIATSAAEVYSPYVGCAERFISRIFDTARKNAPCLIFLDEIDSLVGRRTVSSGGGGGQV 570
            .|:.:.|:|....|:.:.|||.:||.:...|..||..||.:||.||:|:|...|  .|..|.|.|
Human   707 NESGLNFLAIKGPELMNKYVGESERAVRETFRKARAVAPSIIFFDELDALAVER--GSSLGAGNV 769

  Fly   571 QLRILSTLLTEMNGIVGGGSQQHILVVAATNRPDMIDDALLRPGRFDKLIHVPAPDEKSRLALLK 635
            ..|:|:.|||||:||   ...:.:.::|||||||.||.||:||||.|::|:||.||..:|..:.|
Human   770 ADRVLAQLLTEMDGI---EQLKDVTILAATNRPDRIDKALMRPGRIDRIIYVPLPDAATRREIFK 831

  Fly   636 LHSQRMPFHENVFLQEIAARTDRYSGADLCNLCNEAAIEAFQRDFKATEIELQDFEKVLTKQKSS 700
            |....||....|.|.|:..:||.||||::..:|.|||:.|.:.|.:|..|..:.|.:.|:.....
Human   832 LQFHSMPVSNEVDLDELILQTDAYSGAEIVAVCREAALLALEEDIQANLIMKRHFTQALSTVTPR 896

  Fly   701 LTQS 704
            :.:|
Human   897 IPES 900

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG12010	NP_728878.1	CDC48	<220..713	CDD:273521	171/531 (32%)
AFG2A	NP_001425251.1	None