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Protein Alignment Ythdc1 and YTHDC1

DIOPT Version :9

Sequence 1:	NP_647811.2	Gene:	Ythdc1 / 38420	FlyBaseID:	FBgn0027616	Length:	721	Species:	Drosophila melanogaster
Sequence 2:	NP_001317627.1	Gene:	YTHDC1 / 91746	HGNCID:	30626	Length:	735	Species:	Homo sapiens

Alignment Length:	726	Identity:	198/726 - (27%)
Similarity:	268/726 - (36%)	Gaps:	250/726 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly    25 LDENEADIAEELQDFE-FNTRSEASESNGGDSSDSEPSISSVSTATSSLAGSSKRKTKKPAKQSP 88
            ||:...::.|  ||.| :|..||..::....|......:.|..|.....:..|::...||...|
Human    16 LDDILTEVPE--QDDELYNPESEQDKNEKKGSKRKSDRMESTDTKRQKPSVHSRQLVSKPLSSS- 77

  Fly    89 QPAVETKSSKSSAKNKAKREPTPEELNGGKKKKRTDSGTKKTTSSEAS----------------- 136
               |.......|.|.|:..|...||....::.||.|:..|...||.||
Human    78 ---VSNNKRIVSTKGKSATEYKNEEYQRSERNKRLDADRKIRLSSSASREPYKNQPEKTCVRKRD 139

  Fly   137 --DKVKSKSPDTEDR---------QPSAKKSRTKIPS---------------------NANDSAG 169
              .:.||.:||..:|         ..|::.|:.::.|                     ..|:..|
Human   140 PERRAKSPTPDGSERIGLEVDRRASRSSQSSKEEVNSEEYGSDHETGSSGSSDEQGNNTENEEEG 204

  Fly   170 HKSDLSEAE------------------------------------------DEKPSLPTLESDSE 192
            .:.|:.|.|                                          |:|......::.||
Human   205 VEEDVEEDEEVEEDAEEDEEVDEDGEEEEEEEEEEEEEEEEEEEEYEQDERDQKEEGNDYDTRSE 269

  Fly   193 SSDSDSGTQHKRNGGNGGGNGRGKPSSK-----------------SSTPEKDSVGGGTHSHSQKG 240
            :|||.|.:....:|....|:|......|                 |.:...:|..|....|.:..
Human   270 ASDSGSESVSFTDGSVRSGSGTDGSDEKKKERKRARGISPIVFDRSGSSASESYAGSEKKHEKLS 334

  Fly   241 -------YDYMTKLNYLFRDTRFFLIKSNNSDNVQLSKNKSVWATLPQNDANLNQAFKEARNVLL 298
                   .|..:||.|:.:|.|||||||||.:||.|:|.|.||:|||.|:..||.||:.||:|:|
Human   335 SSVRAVRKDQTSKLKYVLQDARFFLIKSNNHENVSLAKAKGVWSTLPVNEKKLNLAFRSARSVIL 399

  Fly   299 IFSVNESGKFAGFARMAAPSRRDIPQVAWVLPPSISPKALGGVIELDWICRKELSFNATLHLHNT 363
            ||||.|||||.||||:::.|......:.||||..:|.|.||||.::|||||:||.|..:.||.|.
Human   400 IFSVRESGKFQGFARLSSESHHGGSPIHWVLPAGMSAKMLGGVFKIDWICRRELPFTKSAHLTNP 464

  Fly   364 WNEGKPVKIGRDGQEIEPKIGGELCRLFPEDEQIELTPILKKSKETARVMREKGIHVIYKPPRSL 428
            |||.|||||||||||||.:.|.:||.|||.||.|:|..::.|
Human   465 WNEHKPVKIGRDGQEIELECGTQLCLLFPPDESIDLYQVIHK----------------------- 506

  Fly   429 SSRGHGGGGRGGGRGSNHDHLGPMRHKRSYHGAPHH--RPYRHHHGMGLPPGGGFKRSGSPYRQM 491
                                   |||||..|..|..  ||.|.                .|.|.:
Human   507 -----------------------MRHKRRMHSQPRSRGRPSRR----------------EPVRDV 532

  Fly   492 G---------------GAAGAPP---GGPGDMAMPSWERYMS----------SAAAAEAYV---- 524
            |               .....||   ..||.:..|.::...|          |....:.::
Human   533 GRRRPEDYDIHNSRKKPRIDYPPEFHQRPGYLKDPRYQEVDSFTNLIPNRRFSGVRRDVFLNGSY 597

  Fly   525 ADYMRNMHGQLPPLPF--VPPFAQLPIPGAGAGAAGALPPGAAAAMYEQLPPPVRYYDGPGAPPL 587
            .||:|..|...||.|:  :||:                 ||     .|| ||...||....
Human   598 NDYVREFHNMGPPPPWQGMPPY-----------------PG-----MEQ-PPHHPYYQHHA---- 635

  Fly   588 PDYPPPQRPPP 598
               ||||..||
Human   636 ---PPPQAHPP 643

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.