Protein Alignment Ythdc1 and ythdc2

DIOPT Version :10

• Sequence 1: NP_647811.2
• Gene: Ythdc1 / 38420
• FlyBaseID: FBgn0027616
• Length: 721
• Species: Drosophila melanogaster
• Sequence 2: XP_021332046.1
• Gene: ythdc2 / 567114
• ZFINID: ZDB-GENE-220119-1
• Length: 1381
• Species: Danio rerio
• Alignment Length: 321
• Identity: 87/321 - (27%)
• Similarity: 140/321 - (43%)
• Gaps: 67/321 - (20%)

  Fly    78 RKTKKPAK---QSPQPAVETKSSKSSAKNKAK--REPTPEELNGGKKKKRTDSGTKKTTSSEASD 137
            |:.:.|:|   |..:..:.|..|..||:.::.  ::||     |..::.|..|....::.:....
Zfish  1118 RRIRSPSKACSQLDESTIRTLVSVLSAEEQSAGLQQPT-----GIGQRPRPVSAEDSSSYTHTHG 1177

  Fly   138 KVKSKSPDTEDRQPSAKKSRTKIPSNANDSAGHKSDLSEAEDEKPSLPTLESDSESSDSDSGTQH 202
            :.:: :.||..::.:|...|.::.|...:...|.|...| ||..|.
Zfish  1178 RSRN-TADTPQQEATASPDRPRLASQLKNPRMHHSRHQE-EDLAPC------------------- 1221

  Fly   203 KRNGGNGGGNGRGKPSSKSSTPEKDSVGGGTHSHSQKGYDYMTKLNYLFRDTRFFLIKSNNSDNV 267
                    |...|..|..::.....:.....||                 ..|:|::||:|..|:
Zfish  1222 --------GISEGPTSPSTALVSMSACVRAPHS-----------------SVRYFIMKSSNPRNI 1261

  Fly   268 QLSKNKSVWATLPQNDANLNQAFKEARNVLLIFSVNESGKFAGFARM--AAPSRRDIPQVAWVLP 330
            :||:.:|||:|.|.|:..||:||:.:..|.|:|||..||.|.|:|||  |..|.|.:
Zfish  1262 ELSQQRSVWSTTPNNEQKLNRAFQNSSAVFLVFSVQGSGHFQGYARMTSAVSSERCL-------- 1318

  Fly   331 PSISPKALGGVIELDWICRKELSFNATLHLHNTWNEGKPVKIGRDGQEIEPKIGGELCRLF 391
             ......||||..:.||..:.|:|..|..|.|.||:.|.|:|.||.||:||..|.:|.:|:
Zfish  1319 -DFGSSGLGGVFSVQWIHTESLAFQLTHKLLNPWNDNKKVQISRDAQELEPHTGNQLLQLW 1378

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ythdc1	NP_647811.2	YTH	255..391	CDD:410979	57/137 (42%)
ythdc2	XP_021332046.1	R3H_DEXH_helicase	36..94	CDD:100077
		PRK11131	169..>1003	CDD:182986
		DEXHc_YTHDC2	183..358	CDD:350745
		ANKYR	<473..>549	CDD:440430
		ANK repeat	496..524	CDD:293786
		SF2_C_RHA	584..739	CDD:350178
		OB_NTP_bind	958..1050	CDD:400182
		YTH	1249..1378	CDD:410979	57/137 (42%)