DRSC/TRiP Functional Genomics Resources

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Protein Alignment Ythdc1 and YTHDF2

DIOPT Version :9

Sequence 1:NP_647811.2 Gene:Ythdc1 / 38420 FlyBaseID:FBgn0027616 Length:721 Species:Drosophila melanogaster
Sequence 2:NP_001166599.1 Gene:YTHDF2 / 51441 HGNCID:31675 Length:579 Species:Homo sapiens


Alignment Length:377 Identity:87/377 - (23%)
Similarity:153/377 - (40%) Gaps:63/377 - (16%)


- Green bases have known domain annotations that are detailed below.


  Fly    61 SISSVSTATSSLAGSSKRKTK---------KPAKQSPQPAVETKSSKSSAKNKAKREPTPEELNG 116
            ||:|...|::||..::....|         |||||  ||.::||:..:.    :...|.|     
Human   215 SITSNIVASNSLPPATIAPPKPASWADIASKPAKQ--QPKLKTKNGIAG----SSLPPPP----- 268

  Fly   117 GKKKKRTDSGT--KKTTSSEASDKVKSKS---PDTEDRQPSAKKSRTKIPSNANDSAGHKSDLSE 176
              .|...|.||  .|...::|..:...::   |.....||..:::... |..|..|.|.::....
Human   269 --IKHNMDIGTWDNKGPVAKAPSQALVQNIGQPTQGSPQPVGQQANNS-PPVAQASVGQQTQPLP 330

  Fly   177 AEDEKPSLPTLESDSES-----SDSDSGTQHKRNGGNGGGNGRGKPSSKSSTPEKDSV---GGGT 233
            ....:|:..:::..:..     :..:.|:....||.:|.|.|:.:..|.|:..|...|   ....
Human   331 PPPPQPAQLSVQQQAAQPTRWVAPRNRGSGFGHNGVDGNGVGQSQAGSGSTPSEPHPVLEKLRSI 395

  Fly   234 HSHSQKGYDYMTKLNYLFRDTRFFLIKSNNSDNVQLSKNKSVWATLPQNDANLNQAFKEARN--- 295
            ::::.|.:|:..|      ..|.|:|||.:.|::..|...::|.:....:..|:.|::....   
Human   396 NNYNPKDFDWNLK------HGRVFIIKSYSEDDIHRSIKYNIWCSTEHGNKRLDAAYRSMNGKGP 454

  Fly   296 VLLIFSVNESGKFAGFARMAAPSRRDIPQVAWVLPPSISPKALGGVIELDWICRKELSFNATLHL 360
            |.|:||||.||.|.|.|.|.:....:.....|      |.....|..::.||..|::..:...|:
Human   455 VYLLFSVNGSGHFCGVAEMKSAVDYNTCAGVW------SQDKWKGRFDVRWIFVKDVPNSQLRHI 513

  Fly   361 HNTWNEGKPVKIGRDGQEIEPKIGGELCRLFPEDEQIELTPILKKSKETARV 412
            ....||.|||...||.||:            |.::..::..|:...|.|..:
Human   514 RLENNENKPVTNSRDTQEV------------PLEKAKQVLKIIASYKHTTSI 553

Known Domains:


Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.

GeneSequenceDomainRegion External IDIdentity
Ythdc1NP_647811.2 YTH 254..392 CDD:309322 38/140 (27%)
YTHDF2NP_001166599.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..45
Localization to mRNA processing bodies (P-bodies). /evidence=ECO:0000269|PubMed:24284625 2..384 40/182 (22%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 247..387 32/153 (21%)
Interaction with m6A-containing mRNAs. /evidence=ECO:0000269|PubMed:24284625 385..579 46/193 (24%)
YTH 411..544 CDD:398013 39/150 (26%)
N6-methyladenosine binding. /evidence=ECO:0000269|PubMed:25412658, ECO:0007744|PDB:4RDN 416..418 1/1 (100%)