Protein Alignment Ythdc1 and ythdc1

DIOPT Version :9

• Sequence 1: NP_647811.2
• Gene: Ythdc1 / 38420
• FlyBaseID: FBgn0027616
• Length: 721
• Species: Drosophila melanogaster
• Sequence 2: NP_001007411.1
• Gene: ythdc1 / 492769
• ZFINID: ZDB-GENE-041114-114
• Length: 679
• Species: Danio rerio
• Alignment Length: 667
• Identity: 193/667 - (28%)
• Similarity: 264/667 - (39%)
• Gaps: 166/667 - (24%)

  Fly    27 ENEADIAEEL------QDFE-FNTRSE--ASESNG-------GDSSDSEPSISS-------VSTA 68
            :.|.::.|::      ||.| :|..||  .:|..|       ||:.|::...:|       :..|
Zfish    10 DGELNVLEDILTDAPDQDDELYNPESEHDVNEKKGSKRKHDRGDAQDAKRLRASGHNTRQPMKRA 74

  Fly    69 TSSLAGSSKRKTKKP-AKQSPQPAVETKSSKSSAKNKAKREPTPEELNGGKKKKRTDSGTKKTTS 132
            ..| :||:.:||..| .:.:|:...:.:.:.|.....::.:.:......|....|......|...
Zfish    75 APS-SGSNGKKTSNPRGRHAPEDLYDDRKNHSGRGGASRADLSKGYGEKGLSSSRDSQRRIKPLM 138

  Fly   133 SEASDKVKSKSPDT------EDRQPSAKKSRTKIPSNANDSAGHKSDLSE-----AEDEKPSLPT 186
            .|.::|::..|.::      ..|:..|........|:...|.|:.||:.|     .|.|:.....
Zfish   139 PELTEKMRRTSEESAGRASRSSREEEAHSEEYATGSSVASSEGNCSDVEEEGAMPEEGEEKEGEE 203

  Fly   187 LESDSESSDSDSGTQHK-------RNGGNGGGNGRGKPSSKSSTPEKDSVGGGTHSHSQKG---- 240
            .|.:.|..|.|...:.:       ...||...:...:..:..|..|..|...|...||..|
Zfish   204 EEEEEEEGDDDDDEEEEYVLEEEDAREGNEQNDYDTRSEASDSRSESVSFSDGESVHSASGSDAS 268

  Fly   241 -----------------YDYMTKLNYLFRDTRFFLIKSNNSDNVQLSKNKSVWATLPQNDANLNQ 288
                             .|.:.||.::.|:.|||||||||.:||.|:|.|.||:|||.|:..||.
Zfish   269 GSEKKHEKLSSSVRDVRKDRINKLKHILREARFFLIKSNNHENVSLAKAKGVWSTLPVNEKKLNA 333

  Fly   289 AFKEARNVLLIFSVNESGKFAGFARMAAPSRRDIPQVAWVLPPSISPKALGGVIELDWICRKELS 353
            ||:.||:|:|||||.|||||.||||:::.|......:.||||..::.|.||||.::|||||:||.
Zfish   334 AFRAARSVVLIFSVRESGKFQGFARLSSESHHGGSPIHWVLPAGMNAKMLGGVFKIDWICRRELP 398

  Fly   354 FNATLHLHNTWNEGKPVKIGRDGQEIEPKIGGELCRLFPEDEQIELTPILKKSKETARVMREKGI 418
            |..|.||.|.|||.||||||||||||||:.|.|||.|||.||.|:|..::.|
Zfish   399 FTKTAHLANPWNEHKPVKIGRDGQEIEPECGTELCMLFPHDESIDLYQVIHK------------- 450

  Fly   419 HVIYKPPRSLSSRGHGGGGRGGGRGSNHDHLGPMRHKRSYHGAPHHRPYRHHHGMGLPPGGGFKR 483
                                             |||||..|..|..|. |..|...:|...|.:|
Zfish   451 ---------------------------------MRHKRRMHSEPRSRG-RLPHREPVPRDMGRRR 481

  Fly   484 SGS-----------------PYRQMGGAAGAPPGGPGDMAMPSWERYMSSA---AAAEAYVADYM 528
            ...                 |.|         ||...|...|..:|..|..   ........|||
Zfish   482 PEEYDMHNRKRPRIDYTPEFPQR---------PGFMQDPRNPPVDRRFSGVRRDVFLNGSYNDYM 537

  Fly   529 RNMHGQLPPLPFVPPFAQLPIPGAGAGAAGALPPGAAAAMYEQLPPPVRYYDGPGAPPLPDYPPP 593
            |..|..:.|.|  |.....|.||.                  :.||...||.  ..||    ||.
Zfish   538 REFHHNIGPPP--PWQGMAPYPGM------------------EHPPQHPYYQ--HHPP----PPQ 576

  Fly   594 QRPPPPGFDKAPSYEEF 610
            ..||..|....|....|
Zfish   577 AHPPYSGHHPMPHDARF 593

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ythdc1	NP_647811.2	YTH	254..392	CDD:309322	85/137 (62%)
ythdc1	NP_001007411.1	EssA	1..>88	CDD:299614	20/78 (26%)
		YTH	299..436	CDD:282058	84/136 (62%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170596017
Domainoid	1	1.000	181	1.000	Domainoid score	I3443
eggNOG	1	0.900	-	-		E1_KOG1902
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	223	1.000	Inparanoid score	I3499
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0007281
OrthoInspector	1	1.000	-	-		oto40083
orthoMCL	1	0.900	-	-		OOG6_105604
Panther	1	1.100	-	-	LDO	PTHR12357
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2345
SonicParanoid	1	1.000	-	-		X6164
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	11	10.870