DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ythdc1 and YTHDF3

DIOPT Version :9

Sequence 1:	NP_647811.2	Gene:	Ythdc1 / 38420	FlyBaseID:	FBgn0027616	Length:	721	Species:	Drosophila melanogaster
Sequence 2:	NP_001264742.1	Gene:	YTHDF3 / 253943	HGNCID:	26465	Length:	588	Species:	Homo sapiens

Alignment Length:	399	Identity:	92/399 - (23%)
Similarity:	152/399 - (38%)	Gaps:	75/399 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    43 TRSEASESNGGDS--SDSEPSISSVSTATSSLAGSSKRKTKKPAKQSPQPAVETKSSKSSAKNKA 105
            |...|..|:|..|  ::|.|.:||.:...:|.|..:    :||||  |||.::.|.:.....:..
Human   210 TVGTALSSSGMTSIATNSVPPVSSAAPKPTSWAAIA----RKPAK--PQPKLKPKGNVGIGGSAV 268

  Fly   106 KREPTPEELNGGKKKKRTDSGTKKTTSSEASDKVKSK------SPDTEDRQP-----------SA 153
            ...|....:|.|             |..|....||:.      .|.|..:||           |.
Human   269 PPPPIKHNMNIG-------------TWDEKGSVVKAPPTQPVLPPQTIIQQPQPLIQPPPLVQSQ 320

  Fly   154 KKSRTKIPSNANDSAGHKSDLSEAEDEKPSLPTLESDSESSDSDSGTQHKRNGGNGGGN-GRG-- 215
            ...:...|.......|.:.. ::....:|....|: :...:..:.|....:|.|.|..| |.|
Human   321 LPQQQPQPPQPQQQQGPQPQ-AQPHQVQPQQQQLQ-NRWVAPRNRGAGFNQNNGAGSENFGLGVV 383

  Fly   216 ----KPSSKSSTPEKDSVGGGTHSHSQKGYDYMTKLNYLFRDTRFFLIKSNNSDNVQLSKNKSVW 276
                .|||....|..:.: ...::::.|.:|:..|      :.|.|:|||.:.|::..|...|:|
Human   384 PVSASPSSVEVHPVLEKL-KAINNYNPKDFDWNLK------NGRVFIIKSYSEDDIHRSIKYSIW 441

  Fly   277 ATLPQNDANLNQAFKEARN---VLLIFSVNESGKFAGFARMAAPSRRDIPQVAWVLPPSISPKAL 338
            .:....:..|:.|::....   :.|:||||.||.|.|.|.|.:....:.....|      |....
Human   442 CSTEHGNKRLDAAYRSLNGKGPLYLLFSVNGSGHFCGVAEMKSVVDYNAYAGVW------SQDKW 500

  Fly   339 GGVIELDWICRKELSFNATLHLHNTWNEGKPVKIGRDGQEIEPKIGGELCRLFPEDEQIELTPIL 403
            .|..|:.||..|::..|...|:....|:.|||...||.||:            |.::..::..|:
Human   501 KGKFEVKWIFVKDVPNNQLRHIRLENNDNKPVTNSRDTQEV------------PLEKAKQVLKII 553

  Fly   404 KKSKETARV 412
            ...|.|..:
Human   554 ATFKHTTSI 562

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ythdc1	NP_647811.2	YTH	254..392	CDD:309322	39/140 (28%)
YTHDF3	NP_001264742.1	YTH	420..553	CDD:367840	40/150 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2345
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.940