Protein Alignment Ythdc1 and Ythdc1

DIOPT Version :9

• Sequence 1: NP_647811.2
• Gene: Ythdc1 / 38420
• FlyBaseID: FBgn0027616
• Length: 721
• Species: Drosophila melanogaster
• Sequence 2: XP_006534926.1
• Gene: Ythdc1 / 231386
• MGIID: 2443713
• Length: 748
• Species: Mus musculus
• Alignment Length: 626
• Identity: 188/626 - (30%)
• Similarity: 263/626 - (42%)
• Gaps: 140/626 - (22%)

  Fly    34 EELQDFEFNTRSEASESNGGDSSDSEPSISSVSTATSSLAGSSKRKTKKPAKQSPQP---AVETK 95
            ||.|..|.|.|.:|.......||.|.....|....|......|:|:.|.|.....:.   .|:.:
Mouse   110 EEYQRSERNKRLDADRKIRLSSSSSREPYKSQPEKTCLRKRDSERRAKSPTPDGSERIGLEVDRR 174

  Fly    96 SSKSSAKNKAKREPTPEELNGGKKKKRTDSGTKKTTSSEASDKVKSKSPDTEDRQPSAKKSRTKI 160
            :|:||..:|       ||:|.      .|.|:...|.|..|.:..:.:.:.|:......:...::
Mouse   175 ASRSSQSSK-------EEVNS------EDYGSDHETGSSGSSEQGNNTENEEEGGEEDVEEDEEV 226

  Fly   161 PSNANDSAGHKSDLSEAEDEKPSLPTLES----------------------DSESSDSDSGTQ-- 201
            ..:|.|......|..|.|:|.......|.                      |:.|..||||::
Mouse   227 DEDAEDDEEVDEDAEEEEEEDEEEEEDEDEDEEEEEYEQDERDQKEEGNDYDTRSEASDSGSESV 291

  Fly   202 -----HKRNGGNGGGNGRGKPSSK------------SSTPEKDSVGGGTHSHSQKG-------YD 242
                 ..|:|....|:...|...|            |.:...:|..|....|.:..       .|
Mouse   292 SFTDGSVRSGSGTDGSDEKKKERKRARGISPIVFDRSGSSASESYAGSEKKHEKLSSSVRAVRKD 356

  Fly   243 YMTKLNYLFRDTRFFLIKSNNSDNVQLSKNKSVWATLPQNDANLNQAFKEARNVLLIFSVNESGK 307
            ..:||.|:.:|.|||||||||.:||.|:|.|.||:|||.|:..||.||:.||:|:|||||.||||
Mouse   357 QTSKLKYVLQDARFFLIKSNNHENVSLAKAKGVWSTLPVNEKKLNLAFRSARSVILIFSVRESGK 421

  Fly   308 FAGFARMAAPSRRDIPQVAWVLPPSISPKALGGVIELDWICRKELSFNATLHLHNTWNEGKPVKI 372
            |.||||:::.|......:.||||..:|.|.||||.::|||||:||.|..:.||.|.|||.|||||
Mouse   422 FQGFARLSSESHHGGSPIHWVLPAGMSAKMLGGVFKIDWICRRELPFTKSAHLTNPWNEHKPVKI 486

  Fly   373 GRDGQEIEPKIGGELCRLFPEDEQIELTPILKKSKETARV---MREKGIHVIYKPPRSLSSRGHG 434
            ||||||||.:.|.:||.|||.||.|:|..::.|.:...|:   .|.:|.....:|.|.:..|
Mouse   487 GRDGQEIELECGTQLCLLFPPDESIDLYQLIHKMRHKRRMHSQPRSRGRPSRREPVRDVGRR--- 548

  Fly   435 GGGRGGGRGSNHD-HLGPMRHKRSYHGAPHHRPYRHHHGMGLPPGGGFKRSGSPYRQMGGAAGAP 498
                   |..::| |....:.:..|....|.||             |:.:. ..|:::.......
Mouse   549 -------RPEDYDIHNSRKKPRIDYPPEFHQRP-------------GYVKD-PRYQEVDSFTNLI 592

  Fly   499 PGGPGDMAMPSWERYMSSAAAAEAYV----ADYMRNMHGQLPPLPF--VPPFAQLPIPGAGAGAA 557
            |.          .|:  |....:.::    .||:|..|...||.|:  :||:
Mouse   593 PN----------RRF--SGVRRDVFLNGSYNDYVREFHNMGPPPPWQGMPPY------------- 632

  Fly   558 GALPPGAAAAMYEQLPPPVRYYDGPGAPPLPDYPPPQRPPP 598
                ||     .|| ||...||....       ||||..||
Mouse   633 ----PG-----IEQ-PPHHPYYQHHA-------PPPQAHPP 656

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ythdc1	NP_647811.2	YTH	254..392	CDD:309322	83/137 (61%)
Ythdc1	XP_006534926.1	YTH	368..505	CDD:367840	71/139 (51%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167850153
Domainoid	1	1.000	176	1.000	Domainoid score	I3610
eggNOG	1	0.900	-	-		E1_KOG1902
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	223	1.000	Inparanoid score	I3519
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0007281
OrthoInspector	1	1.000	-	-		oto94839
orthoMCL	1	0.900	-	-		OOG6_105604
Panther	1	1.100	-	-	LDO	PTHR12357
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2345
SonicParanoid	1	1.000	-	-		X6164
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	12	11.780