DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment TNPO1 and CG8219

DIOPT Version :9

Sequence 1:	NP_002261.3	Gene:	TNPO1 / 3842	HGNCID:	6401	Length:	898	Species:	Homo sapiens
Sequence 2:	NP_648038.1	Gene:	CG8219 / 38722	FlyBaseID:	FBgn0035693	Length:	853	Species:	Drosophila melanogaster

Alignment Length:	887	Identity:	513/887 - (57%)
Similarity:	645/887 - (72%)	Gaps:	39/887 - (4%)

- Green bases have known domain annotations that are detailed below.

Human    13 WKPDEQGLQQILQLLKESQSPDTTIQRTVQQKLEQLNQYPDFNNYLIFVLTKLKSEDEPTRSLSG 77
            |.|.::||||:|.:||:||||....|..||:                       :|:|.|||:||
  Fly     3 WTPRDEGLQQLLPILKDSQSPGKATQLAVQE-----------------------TENEATRSMSG 44

Human    78 LILKNNVKAHFQNFPNGVTDFIKSECLNNIGDSSPLIRATVGILITTIASKGELQNWPDLLPKLC 142
            ||||||::.|.........::||.:||..:|||||.||.|||||||||||...|.|||.|||.||
  Fly    45 LILKNNIRMHDITLQPEHLEYIKHQCLQAVGDSSPEIRGTVGILITTIASNIGLHNWPQLLPSLC 109

Human   143 SLLDSEDYNTCEGAFGALQKICEDSAEILDSDVLDRPLNIMIPKFLQFFKHSSPKIRSHAVACVN 207
            .:||::|||.|||||.||||||||||.||:    :.|||.||||||::||||||||||||:||:|
  Fly   110 EMLDNQDYNVCEGAFSALQKICEDSAGILE----NMPLNTMIPKFLEYFKHSSPKIRSHAIACIN 170

Human   208 QFIISRTQALMLHIDSFIENLFALAGDEEPEVRKNVCRALVMLLEVRMDRLLPHMHNIVEYMLQR 272
            ||||:|:|||||:|||.|:||..:..|.:|.||.|||.|||.|:.||:|.::|||..|:|.:|.|
  Fly   171 QFIINRSQALMLNIDSLIQNLLDVPSDNDPAVRMNVCHALVGLVGVRIDLMMPHMSQIIELILLR 235

Human   273 TQDQDENVALEACEFWLTLAEQPICKDVLVRHLPKLIPVLVNGMKYSDIDIILLKGDVEEDETIP 337
            :||.||||||:|.||||:|.:|..|:|:|...|.:|:||||:..:|::.|||||||||.||:..|
  Fly   236 SQDADENVALQATEFWLSLGKQRNCRDILSPILSQLVPVLVSRTQYTETDIILLKGDVGEDDKEP 300

Human   338 DSEQDIRPRFHRSRTVAQQHDEDGIEEEDDDDDEIDDDDTISDWNLRKCSAAALDVLANVYRDEL 402
            |.:|||.||||.||.       .||..|.|::.  |||...|..|||||||.|||:::.::.|..
  Fly   301 DRQQDISPRFHMSRV-------HGISNELDENS--DDDMWDSALNLRKCSACALDIISKIFGDVC 356

Human   403 LPHILPLLKELLFHHEWVVKESGILVLGAIAEGCMQGMIPYLPELIPHLIQCLSDKKALVRSITC 467
            ||.:||:|||.|||.|||:||||::.|||||||||||:||:||||||:||.||||||.|||||||
  Fly   357 LPLMLPILKEALFHQEWVIKESGVMALGAIAEGCMQGLIPHLPELIPYLITCLSDKKPLVRSITC 421

Human   468 WTLSRYAHWVVSQPPDTYLKPLMTELLKRILDSNKRVQEAACSAFATLEEEACTELVPYLAYILD 532
            ||..|:..||::||.|.||:||:.||||.||||||||||||||||..|||||||:|||||..:|.
  Fly   422 WTFMRFPKWVLNQPHDKYLEPLIEELLKCILDSNKRVQEAACSAFVALEEEACTQLVPYLENMLK 486

Human   533 TLVFAFSKYQHKNLLILYDAIGTLADSVGHHLNKPEYIQMLMPPLIQKWNMLKDEDKDLFPLLEC 597
            |.|.|||||..:||||:||.:|.||:|||||||||:||.:|||||:.|||::||:|||:..||||
  Fly   487 TFVLAFSKYHQRNLLIMYDVVGLLAESVGHHLNKPQYIDILMPPLMDKWNLVKDDDKDIIYLLEC 551

Human   598 LSSVATALQSGFLPYCEPVYQRCVNLVQKTLAQAML-NNAQPDQYEAPDKDFMIVALDLLSGLAE 661
            |||:||||||.|||||:.||::.::::::|:.|.|: ..:|...|  |||:.|::||||:|||.|
  Fly   552 LSSIATALQSSFLPYCDSVYRKGISIIEETINQDMMCKQSQSTDY--PDKERMVIALDLVSGLIE 614

Human   662 GLGGNIEQLVARSNILTLMYQCMQDKMPEVRQSSFALLGDLTKACFQHVKPCIADFMPILGTNLN 726
            ||...||.|||.|.:|.|:.|||.|.|||||||||||||||:.|||..|.|..|.|:.||..|||
  Fly   615 GLQSLIEPLVANSKLLQLLCQCMGDVMPEVRQSSFALLGDLSGACFSQVYPYTAHFILILVQNLN 679

Human   727 PEFISVCNNATWAIGEISIQMGIEMQPYIPMVLHQLVEIINRPNTPKTLLENTAITIGRLGYVCP 791
            |..:.|||||.||||:|.:::|.|.:||:.::|.:|:.::||.:.||.|..|.|||:||||..||
  Fly   680 PSVVGVCNNAVWAIGQICVKLGEETKPYVRLLLSELMILMNRQDIPKNLSRNAAITLGRLGNACP 744

Human   792 QEVAPMLQQFIRPWCTSLRNIRDNEEKDSAFRGICTMISVNPSGVIQDFIFFCDAVASWINPKDD 856
            .||||.|.:|:|.||..||...|::||..:|.|:|.||..||.||:.||:|||||:|||.||..|
  Fly   745 DEVAPYLPEFLRQWCLLLRYAYDHDEKYLSFMGMCHMIRENPGGVVPDFLFFCDAIASWDNPPQD 809

Human   857 LRDMFCKILHGFKNQVGDENWRRFSDQFPLPLKERLAAFYGV 898
            ||.|..:|:.|||||.|.|||..|..:||.||..||...|.:
  Fly   810 LRQMIRRIIEGFKNQTGAENWLIFLGKFPQPLACRLIELYDI 851

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
TNPO1	NP_002261.3	HEAT 1. /evidence=ECO:0000269\|PubMed:10353245	19..46		14/26 (54%)
		KAP95	32..767	CDD:227540	430/735 (59%)
		HEAT 2. /evidence=ECO:0000269\|PubMed:10353245	51..89		14/37 (38%)
		HEAT 3. /evidence=ECO:0000269\|PubMed:10353245	98..131		22/32 (69%)
		HEAT repeat	103..124	CDD:293787	15/20 (75%)
		HEAT 4. /evidence=ECO:0000269\|PubMed:10353245	137..174		27/36 (75%)
		HEAT repeat	137..165	CDD:293787	20/27 (74%)
		HEAT 5. /evidence=ECO:0000269\|PubMed:10353245	181..211		24/29 (83%)
		HEAT repeat	182..212	CDD:293787	24/29 (83%)
		HEAT repeat	223..249	CDD:293787	13/25 (52%)
		HEAT 6. /evidence=ECO:0000269\|PubMed:10353245	224..251		13/26 (50%)
		HEAT repeat	262..291	CDD:293787	18/28 (64%)
		HEAT 7. /evidence=ECO:0000269\|PubMed:10353245	263..290		16/26 (62%)
		HEAT 8. /evidence=ECO:0000269\|PubMed:10353245	306..397		46/90 (51%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	347..374		8/26 (31%)
		HEAT 9. /evidence=ECO:0000269\|PubMed:10353245	405..433		18/27 (67%)
		HEAT repeat	407..431	CDD:293787	16/23 (70%)
		HEAT 10. /evidence=ECO:0000269\|PubMed:10353245	445..472		22/26 (85%)
		HEAT repeat	447..475	CDD:293787	21/27 (78%)
		HEAT 11. /evidence=ECO:0000269\|PubMed:10353245	486..519		26/32 (81%)
		HEAT repeat	488..518	CDD:293787	24/29 (83%)
		HEAT 12. /evidence=ECO:0000269\|PubMed:10353245	527..560		18/32 (56%)
		HEAT repeat	529..555	CDD:293787	14/25 (56%)
		HEAT 13. /evidence=ECO:0000269\|PubMed:10353245	568..606		25/37 (68%)
		HEAT repeat	570..601	CDD:293787	20/30 (67%)
		HEAT 14. /evidence=ECO:0000269\|PubMed:10353245	614..665		21/51 (41%)
		HEAT 15. /evidence=ECO:0000269\|PubMed:10353245	676..707		22/30 (73%)
		HEAT 16. /evidence=ECO:0000269\|PubMed:10353245	715..748		18/32 (56%)
		HEAT 17. /evidence=ECO:0000269\|PubMed:10353245	756..791		15/34 (44%)
		HEAT 18. /evidence=ECO:0000269\|PubMed:10353245	799..832		14/32 (44%)
		HEAT 19. /evidence=ECO:0000269\|PubMed:10353245	841..872		19/30 (63%)
		HEAT 20. /evidence=ECO:0000269\|PubMed:10353245	875..895		10/19 (53%)
CG8219	NP_648038.1	IBN_N	11..76	CDD:281761	30/87 (34%)
		ARM	104..214	CDD:237987	77/113 (68%)
		HEAT repeat	104..132	CDD:293787	20/27 (74%)
		HEAT repeat	145..175	CDD:293787	24/29 (83%)
		HEAT repeat	186..212	CDD:293787	13/25 (52%)
		HEAT repeat	225..254	CDD:293787	18/28 (64%)
		HEAT repeat	360..388	CDD:293787	19/27 (70%)
		HEAT_2	361..465	CDD:290374	78/103 (76%)
		HEAT_EZ	373..424	CDD:290247	41/50 (82%)
		HEAT repeat	400..430	CDD:293787	22/29 (76%)
		HEAT repeat	442..468	CDD:293787	22/25 (88%)
		HEAT repeat	629..657	CDD:293787	21/27 (78%)
		HEAT_EZ	642..696	CDD:290247	36/53 (68%)
		HEAT repeat	667..699	CDD:293787	18/31 (58%)
		HEAT repeat	710..738	CDD:293787	11/27 (41%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165155663
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2023
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53589
OrthoDB	1	1.010	-	-		D525700at2759
OrthoFinder	1	1.000	-	-		FOG0001564
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_101362
Panther	1	1.100	-	-	O	PTHR10527
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X877
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	11	10.720