DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment kst and SPTBN2

DIOPT Version :10

Sequence 1:NP_001097492.2 Gene:kst / 38418 FlyBaseID:FBgn0004167 Length:4337 Species:Drosophila melanogaster
Sequence 2:NP_001397954.1 Gene:SPTBN2 / 6712 HGNCID:11276 Length:2397 Species:Homo sapiens


Alignment Length:2510 Identity:758/2510 - (30%)
Similarity:1227/2510 - (48%) Gaps:317/2510 - (12%)


- Green bases have known domain annotations that are detailed below.


  Fly    25 QSLASQYEPGGYSALQTPTPSNRNSANMTQRDGIIKFENERIKTLQEERLHIQKKTFTKWMNSFL 89
            :::...:.|||  .|.:|..    ..|..|...:::   .|.|.||:||..:||||||||:||.|
Human    23 EAVEGAHNPGG--LLLSPAA----FINPAQYASVLE---GRFKQLQDEREAVQKKTFTKWVNSHL 78

  Fly    90 IKAKMEVEDLFTDLADGIKLLKLLEIISSEKLGKPNSGRMRVHKIENVNKSLAFL-HTKVRLESI 153
            .:....|.||::||.||..||:|||::|.|.|.||..||||:|.:|||:|:|.|| ..||.||::
Human    79 ARVTCRVGDLYSDLRDGRNLLRLLEVLSGEILPKPTKGRMRIHCLENVDKALQFLKEQKVHLENM 143

  Fly   154 GAEDIVDGNPRLILGLIWTIILRFQIQEIEIDVDEENESSEKRSAKDALLLWCQRKTHGYPGVNI 218
            |:.||||||.||.|||:||||||||||:|.:   |..::.||:|||||||||||.||.|||.||:
Human   144 GSHDIVDGNHRLTLGLVWTIILRFQIQDISV---ETEDNKEKKSAKDALLLWCQMKTAGYPNVNV 205

  Fly   219 TDFTNSWRSGLGFNALIHSHRPDLFEYSTIVNSKNSNLD-NLNHAFDTAANELGIPSLLDAEDID 282
            .:||.|||.||.|||::|.|||||.::.::   |..|.. ||.:||:.|..|||:..|||.||::
Human   206 HNFTTSWRDGLAFNAIVHKHRPDLLDFESL---KKCNAHYNLQNAFNLAEKELGLTKLLDPEDVN 267

  Fly   283 SARPDEKSILTYVASYYHTFARMKNEQKSGKRIANIVGQLMDADRKKMQYEGLTTNLLSWIRQKT 347
            ..:||||||:||||:|||.|::||.....||||..::...|:|:|...:||.|.:.||.||.|..
Human   268 VDQPDEKSIITYVATYYHYFSKMKALAVEGKRIGKVLDHAMEAERLVEKYESLASELLQWIEQTI 332

  Fly   348 LELEQRDLPNSLEGIQRELLAFKEYRTIEKPPKYKERSEIEALYFTINTLLKALNQPPYNPQDGQ 412
            :.|..|.|.|||.|:|.:|.:|..|||:|||||:.|:..:|.|.|||.:.|:|.||..|.|::|:
Human   333 VTLNDRQLANSLSGVQNQLQSFNSYRTVEKPPKFTEKGNLEVLLFTIQSKLRANNQKVYTPREGR 397

  Fly   413 LVNDIEKAWQILEYAEHHREVALRDELLRQEKLEQLNYKFEKKSVLREGYLKEMIQVLSDPRY-- 475
            |::||.|||:.||.|||.||:|||.||:||||||||..:|::|:.:||.:|.|..:::|...:  
Human   398 LISDINKAWERLEKAEHERELALRTELIRQEKLEQLAARFDRKAAMRETWLSENQRLVSQDNFGL 462

  Fly   476 -LRQVDATLKKHEAISADILARVERFNDLTAMAEELDRENYHGKERVRRREQEVMAKWRQLLELL 539
             |..|:|.::|||||..||:|...|...:.|:|.||..|.||..:|:..|:..|...|..|.:::
Human   463 ELAAVEAAVRKHEAIETDIVAYSGRVQAVDAVAAELAAERYHDIKRIAARQHNVARLWDFLRQMV 527

  Fly   540 ENQRLNLSQMSNLMNLLREIASTTEAVRELQQQFASEDVGPHLLGVEELLQAHSLQELQVNTYGE 604
            ..:|..|.....|..:.:::....:.:.|::.:..|:|:|.||.|||:|||.|.|.|..:....|
Human   528 AARRERLLLNLELQKVFQDLLYLMDWMEEMKGRLQSQDLGRHLAGVEDLLQLHELVEADIAVQAE 592

  Fly   605 TLKRFNRQAL----PYKSSEHKDAALLAQRLADLEEAYSELLRRSAARRARLEEARNFHHFMEDY 665
            .::..:..||    |.|.....|..|:::|:|.||::|..|...:|||||||||:|....|:.:.
Human   593 RVRAVSASALRFCNPGKEYRPCDPQLVSERVAKLEQSYEALCELAAARRARLEESRRLWRFLWEV 657

  Fly   666 DNEESWLVDKQRICKTGITAKDLRAVLSLQQKHKALEDEIKSRKPKSGQMSTAGKRLIGEQHPRS 730
            ...|:|:.::|.:..:..|.:||...|.|..||.||..|:..|..........|::|:.|.||.:
Human   658 GEAEAWVREQQHLLASADTGRDLTGALRLLNKHTALRGEMSGRLGPLKLTLEQGQQLVAEGHPGA 722

  Fly   731 SEIQSRIDSLAEHWQALEALVELRRRQLEDAAEAYQFYTDANEAESWLNEKIALVNSRDYGNDEP 795
            |:..:|...|...|:.||||.|.|.::|..||..|||..|||:.|:||.:.:.||:|.:.|:||.
Human   723 SQASARAAELQAQWERLEALAEERAQRLAQAASLYQFQADANDMEAWLVDALRLVSSPELGHDEF 787

  Fly   796 SAQALLQRHRDLQGELNAYSGDILNLNQQADKLIKAGICTLELSAAEPELPEVEQEEWVNETRLV 860
            |.|||.::||.|:.|:.::...:..|.:||..|                                
Human   788 STQALARQHRALEEEIRSHRPTLDALREQAAAL-------------------------------- 820

  Fly   861 PKEVWEDEWVEKLEHKKVTETKMLPHVKSLFPFEGQGMKMDKGEVMLLKSKTNDDWWCVRKDNGV 925
                                                                             
Human   821 ----------------------------------------------------------------- 820

  Fly   926 EGFVPANYVREVEPRPVACIVPKAEKVKSLQKVKKTILVRQVVPVKRIKPVSVAPKPLVQRRTST 990
                                                             |.:::..|.||.|..|
Human   821 -------------------------------------------------PPTLSRTPEVQSRVPT 836

  Fly   991 QSINENADSVEKRQQRINQTYDELQEMAQKRHALLEDSIHLFGFYRECDDFEKWMKEKERMIKS- 1054
                            :.:.|:|||..|.:|...||.::.|:....|......|::|||:.:.. 
Human   837 ----------------LERHYEELQARAGERARALEAALALYTMLSEAGACGLWVEEKEQWLNGL 885

  Fly  1055 ---DEGEGVDNAKRKFEKFITDLSAASKRVEEIDGAVDTFRRQGHSQLDKIIARQRQIHQIWQRL 1116
               :..|.::..:::||....:::..:.::..::...:...:......|:|:..|.|::..||:.
Human   886 ALPERLEDLEVVQQRFETLEPEMNTLAAQITAVNDIAEQLLKANPPGKDRIVNTQEQLNHRWQQF 950

  Fly  1117 NNAKAQREKSLEGASSVELFNRTCDEAKVWMSEKMLQLD-TAVITPDLRTVQALQRRHQNLEREL 1180
            ......::.:|..|.|::.::..|.|.:.||.||...:: |..:..||..|.||||:....||:|
Human   951 RRLADGKKAALTSALSIQNYHLECTETQAWMREKTKVIESTQGLGNDLAGVLALQRKLAGTERDL 1015

  Fly  1181 APVEDKVNRVTYLGNSVKNAYPAEKDNVNARQQEVQDMWQQVQQRGSDLRNRIESEVGQ----QV 1241
            ..:..:|..:|...|::...:||:...:|||.:|||..|:.::   :.:|.|.|| :|:    |.
Human  1016 EAIAARVGELTREANALAAGHPAQAVAINARLREVQTGWEDLR---ATMRRREES-LGEARRLQD 1076

  Fly  1242 FNNSAKVLLAWIDSVKDQLNADESARDVETANNLLKKHNDLGDDIRAHDTEFVEVIQLGKQLS-- 1304
            |..|.....||:...:..:.::|....:..|..||.:|..|..::....:|:..:..||::::  
Human  1077 FLRSLDDFQAWLGRTQTAVASEEGPATLPEAEALLAQHAALRGEVERAQSEYSRLRALGEEVTRD 1141

  Fly  1305 DGKPNMAETVAVIERLKAEQDAIHRGWAEKQKWLLQCVDLQMFNREADKIDATTKSHEAFLEYNN 1369
            ...|........:|.|....:.:.|.|..:|..|.|....|.|.|:|.:.:....|.|..|.:..
Human  1142 QADPQCLFLRQRLEALGTGWEELGRMWESRQGRLAQAHGFQGFLRDARQAEGVLSSQEYVLSHTE 1206

  Fly  1370 LGASLDEVEAILKRHLDFEKSLMAQDKILKGFSDNADKLISNDHYDSKYIGDRRNQVLGKRKAVK 1434
            :..:|...:|.:|:..||..::.|..:.:.|..:...:|:|..:..:..|.::.:.:..:.|..:
Human  1207 MPGTLQAADAAIKKLEDFMSTMDANGERIHGLLEAGRQLVSEGNIHADKIREKADSIERRHKKNQ 1271

  Fly  1435 DRAFERKRLLQASKDFHKFAAEADDLKVWLQDKTRIAGDENYRDLSNLPRKLQKHQAFERELRAN 1499
            |.|.:....|:.:::...|..:..:||:|:.:|...|.|.:|.:..||..|.||||||..||.||
Human  1272 DAAQQFLGRLRDNREQQHFLQDCHELKLWIDEKMLTAQDVSYDEARNLHTKWQKHQAFMAELAAN 1336

  Fly  1500 EGQLRNVTKDGQALVQAGNRVPE----VESRVADLNKRWKDLLTLSEDKGRKLEQAASQREHNRS 1560
            :..|..|.|:|:.|..   ..||    |..::.||::||.:|.|.::.|.|.|..|.......:|
Human  1337 KDWLDKVDKEGRELTL---EKPELKALVSEKLRDLHRRWDELETTTQAKARSLFDANRAELFAQS 1398

  Fly  1561 LEDAKKKVDELDSALRSGDVGNDLRSCKDLINKQQILESEITIWDQKVAELVSTGDDMAHGGHFN 1625
            ....:..::.|.:.|.|.|.|.||.|...|:.|||:||.|:.:.:::|..:.:....:|.... .
Human  1399 CCALESWLESLQAQLHSDDYGKDLTSVNILLKKQQMLEWEMAVREKEVEAIQAQAKALAQEDQ-G 1462

  Fly  1626 AQNIEAGTKELQQRFKDLRDPTQRRRAKLEESLNYHKFVFELDSEFQWINEHLPAAKSNELGQNL 1690
            |..:|..::.::::|:.|..|.:.|..:|:.|...|:|..:::.|..|:.|.||.|.|.|.|::|
Human  1463 AGEVERTSRAVEEKFRALCQPMRERCRRLQASREQHQFHRDVEDEILWVTERLPMASSMEHGKDL 1527

  Fly  1691 HQAQSLHKKHKKLEAEIKGHQPMI------NKALVAGQSLISQQHPEREQVESLCQQLEQAWQDL 1749
            ...|.|.||::.|:.||:||:|.|      .:||.|..:     .||       ..:|::.|:.|
Human  1528 PSVQLLMKKNQTLQKEIQGHEPRIADLRERQRALGAAAA-----GPE-------LAELQEMWKRL 1580

  Fly  1750 ERHCGERSRKLDMSLKAQQYLFDAGEIESWLGERNNVLRSTEYGRDRDSAAKLLTKHKTIELELD 1814
            ......|.::|:.:|:|||:..||.|.|:|:||:...:...|..:|..||...:.||:.:|..|.
Human  1581 GHELELRGKRLEDALRAQQFYRDAAEAEAWMGEQELHMMGQEKAKDELSAQAEVKKHQVLEQALA 1645

  Fly  1815 TYSGIVTEMGHSCAAMVAANHPDSKVLAAKQQLIEKMLKSLHKLASQRQGRLMESLYKHEYFLES 1879
            .|:..:.::..|...|:...||:|..::.:|..::|:...|.:||.:|:.||.|.|...:...|.
Human  1646 DYAQTIHQLAASSQDMIDHEHPESTRISIRQAQVDKLYAGLKELAGERRERLQEHLRLCQLRREL 1710

  Fly  1880 DEVEQWIREQEQAASSEDYGQDFEHLQLLQNKFDDLKHRVE-VGADRVDQCELLAKKLIDSESPY 1943
            |::||||:|:|..|:|.:.|||:||:.:|::||.:...... :|.:|||....||..||......
Human  1711 DDLEQWIQEREVVAASHELGQDYEHVTMLRDKFREFSRDTSTIGQERVDSANALANGLIAGGHAA 1775

  Fly  1944 ANEVEKRQEQLRTSWENLLQLLNQREQKLHAAGEIHRFHRDVAEALFRIQDKNAALSQELGRDLN 2008
            ...|.:.::.|..:|.:||:||:.|.|.|.||.|:.||.....:||.|:|.|...|....|||||
Human  1776 RATVAEWKDSLNEAWADLLELLDTRGQVLAAAYELQRFLHGARQALARVQHKQQQLPDGTGRDLN 1840

  Fly  2009 SALALLRKHEGFENDLVALEAQLQVLVEDSVRLQAKYPSN-ASAIAQQQDKVVAAWNDLKERSTA 2072
            :|.||.|:|..:|:|:.||..|:|.:.:|..|||..|..: |..|.:....|..||..|:..|.|
Human  1841 AAEALQRRHCAYEHDIQALSPQVQQVQDDGHRLQKAYAGDKAEEIGRHMQAVAEAWAQLQGSSAA 1905

  Fly  2073 RGDRLAASSDLQTFLTDVRDIVSWSSNLRAALQAEEHVSDAAGATALKIQHDAIYGEIEAREDKF 2137
            |...|..::|...|...||:::.|...:...:.|:|...|.:.|..:......|..|||||.|:|
Human  1906 RRQLLLDTTDKFRFFKAVRELMLWMDEVNLQMDAQERPRDVSSADLVIKNQQGIKAEIEARADRF 1970

  Fly  2138 RYLNELSDSMVQTGHYAAADVEEKCAAMLDERQKLHAAWNKKKIMLEQKIDLFCFLRDAKQIDNL 2202
            ....::...::...||||.::.||.:.:...||:....|.:|...|:..:::..|.|||...:..
Human  1971 SSCIDMGKELLARSHYAAEEISEKLSQLQARRQETAEKWQEKMDWLQLVLEVLVFGRDAGMAEAW 2035

  Fly  2203 SSSQQAALSSSDFGQTVEDVQNKIRKHDEFERLIQTQE------EKVSLLQEHGRKLIEQRHYDS 2261
            ..||:..:.|::.|.||::|::.|::|:.|::.....|      ||::.|:|..::...:|..:.
Human  2036 LCSQEPLVRSAELGCTVDEVESLIKRHEAFQKSAVAWEERFCALEKLTALEEREKERKRKREEEE 2100

  Fly  2262 ANIQ--------TILQGVLARRQKVKD---------------------LCA--------VRRYKL 2289
            ...|        ::..|.|...|...|                     :|.        :.:.:|
Human  2101 RRKQPPAPEPTASVPPGDLVGGQTASDTTWDGTQPRPPPSTQAPSVNGVCTDGEPSQPLLGQQRL 2165

  Fly  2290 EDALLYAKFVRDCA-----EAKYWINEKQKKLEADAASYAEVTNLDEKIKKLQKHQAFQAEVAAN 2349
            |    ::.|.....     ||.....|:|.:....|.|         .:.:.:..::..|.....
Human  2166 E----HSSFPEGPGPGSGDEANGPRGERQTRTRGPAPS---------AMPQSRSTESAHAATLPP 2217

  Fly  2350 QGRIQEIQDTGVILLSKQHESSPEIKRAIEIVLEAWQGLLAELEQRGRG---------------- 2398
            :|.....|:....:|.::.|.....|:|..   .:||.:...|.:...|                
Human  2218 RGPEPSAQEQMEGMLCRKQEMEAFGKKAAN---RSWQNVYCVLRRGSLGFYKDAKAASAGVPYHG 2279

  Fly  2399 -----LEEAQDSLEFNSQLDK--IEAWIRD-KEMMVQASD 2430
                 |..||.|:.|:.:..|  .:..::| ||.:.||.|
Human  2280 EVPVSLARAQGSVAFDYRKRKHVFKLGLQDGKEYLFQAKD 2319

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
kstNP_001097492.2 CH_beta_spectrin_rpt1 61..176 CDD:409042 66/115 (57%)
CH_beta_spectrin_rpt2 196..302 CDD:409043 62/106 (58%)
SPEC 450..640 CDD:238103 61/196 (31%)
SPEC 658..832 CDD:238103 60/173 (35%)
SH3 885..935 CDD:214620 0/49 (0%)
SPEC 1030..1236 CDD:238103 50/210 (24%)
SPEC 1134..1341 CDD:238103 55/213 (26%)
SPEC 1343..1551 CDD:238103 59/211 (28%)
SPEC 1449..1658 CDD:238103 64/212 (30%)
SPEC 1555..1764 CDD:238103 59/214 (28%)
SPEC 1765..1975 CDD:238103 70/210 (33%)
SPEC 1873..2080 CDD:238103 78/208 (38%)
SPEC 1979..2185 CDD:238103 67/206 (33%)
SPEC 2188..2402 CDD:238103 47/282 (17%)
SPEC 2407..2618 CDD:238103 8/27 (30%)
SPEC 2514..2725 CDD:238103
SPEC 2726..2934 CDD:238103
SPEC 2935..3145 CDD:238103
SPEC 3042..3251 CDD:238103
SPEC 3149..3357 CDD:238103
SPEC 3359..3567 CDD:238103
SPEC 3465..3680 CDD:238103
PH_beta_spectrin 3801..3904 CDD:269975
SPTBN2NP_001397954.1 CH_SPTB-like_rpt1 52..166 CDD:409095 66/116 (57%)
CH_SPTBN2_rpt2 180..298 CDD:409170 67/120 (56%)
Spectrin 312..421 CDD:395348 54/108 (50%)
Spectrin 436..529 CDD:395348 31/92 (34%)
SPEC 541..753 CDD:238103 69/211 (33%)
SPEC 756..965 CDD:238103 57/370 (15%)
SPEC 968..1179 CDD:238103 56/214 (26%)
SPEC 1181..1390 CDD:238103 59/211 (28%)
SPEC 1391..1595 CDD:238103 59/216 (27%)
SPEC 1596..1808 CDD:238103 71/211 (34%)
SPEC 1809..2017 CDD:238103 67/207 (32%)
SPEC 2025..>2082 CDD:197544 16/56 (29%)
dnaA <2104..>2248 CDD:455861 22/159 (14%)
PH_beta_spectrin 2228..2331 CDD:269975 20/95 (21%)
Blue background indicates that the domain is not in the aligned region.

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