DRSC/TRiP Functional Genomics Resources

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Protein Alignment kst and SPTBN1

DIOPT Version :10

Sequence 1:NP_001097492.2 Gene:kst / 38418 FlyBaseID:FBgn0004167 Length:4337 Species:Drosophila melanogaster
Sequence 2:NP_003119.2 Gene:SPTBN1 / 6711 HGNCID:11275 Length:2364 Species:Homo sapiens


Alignment Length:2508 Identity:768/2508 - (30%)
Similarity:1277/2508 - (50%) Gaps:315/2508 - (12%)


- Green bases have known domain annotations that are detailed below.


  Fly    61 FENERIKTLQEERLHIQKKTFTKWMNSFLIKAKMEVEDLFTDLADGIKLLKLLEIISSEKLGKPN 125
            ||..|||.|.:||..:||||||||:||.|.:....:.||:|||.||..|:||||::|.|:|.||.
Human    40 FERSRIKALADEREAVQKKTFTKWVNSHLARVSCRITDLYTDLRDGRMLIKLLEVLSGERLPKPT 104

  Fly   126 SGRMRVHKIENVNKSLAFL-HTKVRLESIGAEDIVDGNPRLILGLIWTIILRFQIQEIEIDVDEE 189
            .||||:|.:|||:|:|.|| ..:|.||::|:.||||||.||.||||||||||||||:|.:   |.
Human   105 KGRMRIHCLENVDKALQFLKEQRVHLENMGSHDIVDGNHRLTLGLIWTIILRFQIQDISV---ET 166

  Fly   190 NESSEKRSAKDALLLWCQRKTHGYPGVNITDFTNSWRSGLGFNALIHSHRPDLFEYSTIVNSKNS 254
            .::.||:|||||||||||.||.|||.|||.:||.|||.|:.||||||.|||||.::..:   |.|
Human   167 EDNKEKKSAKDALLLWCQMKTAGYPNVNIHNFTTSWRDGMAFNALIHKHRPDLIDFDKL---KKS 228

  Fly   255 NLD-NLNHAFDTAANELGIPSLLDAEDIDSARPDEKSILTYVASYYHTFARMKNEQKSGKRIANI 318
            |.. ||.:||:.|...||:..|||.|||....||||||:|||.:|||.|::||.....||||..:
Human   229 NAHYNLQNAFNLAEQHLGLTKLLDPEDISVDHPDEKSIITYVVTYYHYFSKMKALAVEGKRIGKV 293

  Fly   319 VGQLMDADRKKMQYEGLTTNLLSWIRQKTLELEQRDLPNSLEGIQRELLAFKEYRTIEKPPKYKE 383
            :...::.::...:||.|.::||.||.|..:.|..|...|||.|:|::|.||..|||:|||||:.|
Human   294 LDNAIETEKMIEKYESLASDLLEWIEQTIIILNNRKFANSLVGVQQQLQAFNTYRTVEKPPKFTE 358

  Fly   384 RSEIEALYFTINTLLKALNQPPYNPQDGQLVNDIEKAWQILEYAEHHREVALRDELLRQEKLEQL 448
            :..:|.|.|||.:.::|.||..|.|::|:|::||.|||:.||.|||.||:|||:||:||||||||
Human   359 KGNLEVLLFTIQSKMRANNQKVYMPREGKLISDINKAWERLEKAEHERELALRNELIRQEKLEQL 423

  Fly   449 NYKFEKKSVLREGYLKEMIQVLSDPRY---LRQVDATLKKHEAISADILARVERFNDLTAMAEEL 510
            ..:|::|:.:||.:|.|..:::|...:   |..|:|..||||||..||.|..||...:.|:|.||
Human   424 ARRFDRKAAMRETWLSENQRLVSQDNFGFDLPAVEAATKKHEAIETDIAAYEERVQAVVAVAREL 488

  Fly   511 DRENYHGKERVRRREQEVMAKWRQLLELLENQRLNLSQMSNLMNLLREIASTTEAVRELQQQFAS 575
            :.||||..:|:..|:..|:..|..|||||..:|..|.....|..:.:|:....:.:.|::....|
Human   489 EAENYHDIKRITARKDNVIRLWEYLLELLRARRQRLEMNLGLQKIFQEMLYIMDWMDEMKVLVLS 553

  Fly   576 EDVGPHLLGVEELLQAHSLQELQVNTYGETLKRFNRQALPYKSS----EHKDAALLAQRLADLEE 636
            :|.|.||||||:|||.|:|.|..:....|.::..|..|..:.:.    :..|..::..|:|.:|.
Human   554 QDYGKHLLGVEDLLQKHTLVEADIGIQAERVRGVNASAQKFATDGEGYKPCDPQVIRDRVAHMEF 618

  Fly   637 AYSELLRRSAARRARLEEARNFHHFMEDYDNEESWLVDKQRICKTGITAKDLRAVLSLQQKHKAL 701
            .|.||.:.:|.|||||||:|....|..:...||.|:.:|::|..:....|||.:|:.|..||:|.
Human   619 CYQELCQLAAERRARLEESRRLWKFFWEMAEEEGWIREKEKILSSDDYGKDLTSVMRLLSKHRAF 683

  Fly   702 EDEIKSRKPKSGQMSTAGKRLIGEQHPRSSEIQSRIDSLAEHWQALEALVELRRRQLEDAAEAYQ 766
            |||:..|.....|....|:.:|.|:|..|.:|:.||..:.|.|..||.|..:|:::||:|:..:|
Human   684 EDEMSGRSGHFEQAIKEGEDMIAEEHFGSEKIRERIIYIREQWANLEQLSAIRKKRLEEASLLHQ 748

  Fly   767 FYTDANEAESWLNEKIALVNSRDYGNDEPSAQALLQRHRDLQGELNAYSGDILNLNQQADKLIKA 831
            |..||::.::|:.:.:.:|:|.|.|:||.|.|:|:::|:|:..|:..|...:..|::||..|   
Human   749 FQADADDIDAWMLDILKIVSSSDVGHDEYSTQSLVKKHKDVAEEIANYRPTLDTLHEQASAL--- 810

  Fly   832 GICTLELSAAEPELPEVEQEEWVNETRLVPKEVWEDEWVEKLEHKKVTETKMLPHVKSLFPFEGQ 896
                                         |:|                      |.:|       
Human   811 -----------------------------PQE----------------------HAES------- 817

  Fly   897 GMKMDKGEVMLLKSKTNDDWWCVRKDNGVEGFVPANYVREVEPRPVACIVPKAEKVKSLQKVKKT 961
                                                                             
Human   818 ----------------------------------------------------------------- 817

  Fly   962 ILVRQVVPVKRIKPVSVAPKPLVQRRTSTQSINENADSVEKRQQRINQTYDELQEMAQKRHALLE 1026
                                |.|:.|.|         .:|:|       |.|:.|:.:.|...|:
Human   818 --------------------PDVRGRLS---------GIEER-------YKEVAELTRLRKQALQ 846

  Fly  1027 DSIHLFGFYRECDDFEKWMKEKERMIKS----DEGEGVDNAKRKFEKFITDLSAASKRVEEIDGA 1087
            |::.|:..:.|.|..|.|:.|||:.:.:    ::.|.::..:.:||....:::..:.||..::..
Human   847 DTLALYKMFSEADACELWIDEKEQWLNNMQIPEKLEDLEVIQHRFESLEPEMNNQASRVAVVNQI 911

  Fly  1088 VDTFRRQGHSQLDKIIARQRQIHQIWQRLNNAKAQREKSLEGASSVELFNRTCDEAKVWMSEKML 1152
            .......||....:|.|:|.:::..|.:......:::.:|..|.|::.::..|:|.|.|:.||..
Human   912 ARQLMHSGHPSEKEIKAQQDKLNTRWSQFRELVDRKKDALLSALSIQNYHLECNETKSWIREKTK 976

  Fly  1153 QLD-TAVITPDLRTVQALQRRHQNLERELAPVEDKVNRVTYLGNSVKNAYPAEKDNVNARQQEVQ 1216
            .:: |..:..||..|.||||:...:||:|..:|.|::.:......:::.:|.:...:.:|..|:.
Human   977 VIESTQDLGNDLAGVMALQRKLTGMERDLVAIEAKLSDLQKEAEKLESEHPDQAQAILSRLAEIS 1041

  Fly  1217 DMWQQVQQRGSDLRNRIESEVGQ----QVFNNSAKVLLAWIDSVKDQLNADESARDVETANNLLK 1277
            |:|::::   :.|:|| |:.:|:    |.|........:|:...:..:.:::....:..|..||.
Human  1042 DVWEEMK---TTLKNR-EASLGEASKLQQFLRDLDDFQSWLSRTQTAIASEDMPNTLTEAEKLLT 1102

  Fly  1278 KHNDLGDDIRAHDTEFVEVIQLGKQLSDGKPNMAETVAVIERLKAEQ---DAIHRGWAEKQKWLL 1339
            :|.::.::|..::.::.::..:|:.::.|:.: |:.:.:.:||:|..   :.:|:.|..:|..|.
Human  1103 QHENIKNEIDNYEEDYQKMRDMGEMVTQGQTD-AQYMFLRQRLQALDTGWNELHKMWENRQNLLS 1166

  Fly  1340 QCVDLQMFNREADKIDATTKSHEAFLEYNNLGASLDEVEAILKRHLDFEKSLMAQDKILKGFSDN 1404
            |....|.|.|:..:.:|...:.|..|.:..:..:|:..||.:|:..||..::.|.::.:....:.
Human  1167 QSHAYQQFLRDTKQAEAFLNNQEYVLAHTEMPTTLEGAEAAIKKQEDFMTTMDANEEKINAVVET 1231

  Fly  1405 ADKLISNDHYDSKYIGDRRNQVLGKRKAVKDRAFERKRLLQASKDFHKFAAEADDLKVWLQDKTR 1469
            ..:|:|:.:.:|..|.::.:.:..:.:..::.|.|....|:.::|..||..:..:|.:|:.:|..
Human  1232 GRRLVSDGNINSDRIQEKVDSIDDRHRKNRETASELLMRLKDNRDLQKFLQDCQELSLWINEKML 1296

  Fly  1470 IAGDENYRDLSNLPRKLQKHQAFERELRANEGQLRNVTKDGQALVQAGNRVPEVES----RVADL 1530
            .|.|.:|.:..||..|..|||||..||.:|:..|..:.|:|..|:   :..||.|:    ::..|
Human  1297 TAQDMSYDEARNLHSKWLKHQAFMAELASNKEWLDKIEKEGMQLI---SEKPETEAVVKEKLTGL 1358

  Fly  1531 NKRWKDLLTLSEDKGRKLEQAASQREHNRSLEDAKKKVDELDSALRSGDVGNDLRSCKDLINKQQ 1595
            :|.|:.|.:.::.|.::|..|.......:|..|..|.:..|:|.::|.|.|.||.|...|:.|||
Human  1359 HKMWEVLESTTQTKAQRLFDANKAELFTQSCADLDKWLHGLESQIQSDDYGKDLTSVNILLKKQQ 1423

  Fly  1596 ILESEITIWDQKVAELVSTGDDMAHGGHFNAQNIEAGTKELQQRFKDLRDPTQRRRAKLEESLNY 1660
            :||:::.:..:::.||.|....::..|. :...:::....:|.:|.:|.:|...|:..|..|...
Human  1424 MLENQMEVRKKEIEELQSQAQALSQEGK-STDEVDSKRLTVQTKFMELLEPLNERKHNLLASKEI 1487

  Fly  1661 HKFVFELDSEFQWINEHLPAAKSNELGQNLHQAQSLHKKHKKLEAEIKGHQPMINKALVAGQSLI 1725
            |:|..:::.|..|:.|.:|.|.|.:.|.||...|.|.||::.|:.||:||||.|:......|:::
Human  1488 HQFNRDVEDEILWVGERMPLATSTDHGHNLQTVQLLIKKNQTLQKEIQGHQPRIDDIFERSQNIV 1552

  Fly  1726 SQQHP-EREQVESLCQQLEQAWQDLERHCGERSRKLDMSLKAQQYLFDAGEIESWLGERNNVLRS 1789
            :.... ..|.:......|:|.|..|.....:|.|:|:.:.:||||.|||.|.|:|:.|:...:.|
Human  1553 TDSSSLSAEAIRQRLADLKQLWGLLIEETEKRHRRLEEAHRAQQYYFDAAEAEAWMSEQELYMMS 1617

  Fly  1790 TEYGRDRDSAAKLLTKHKTIELELDTYSGIVTEMGHSCAAMVAANHPDSKVLAAKQQLIEKMLKS 1854
            .|..:|..||..:|.||:.:|..::.|:..|.::..:..|:||.:||:|:.::.:|..::|:...
Human  1618 EEKAKDEQSAVSMLKKHQILEQAVEDYAETVHQLSKTSRALVADSHPESERISMRQSKVDKLYAG 1682

  Fly  1855 LHKLASQRQGRLMESLYKHEYF---LESDEVEQWIREQEQAASSEDYGQDFEHLQLLQNKFDDL- 1915
            |..||.:|:|:|.|   :|..|   .|.|::||||.|:|..|.|.:.|||:||:.:||.:|.:. 
Human  1683 LKDLAEERRGKLDE---RHRLFQLNREVDDLEQWIAEREVVAGSHELGQDYEHVTMLQERFREFA 1744

  Fly  1916 KHRVEVGADRVDQCELLAKKLIDSESPYANEVEKRQEQLRTSWENLLQLLNQREQKLHAAGEIHR 1980
            :....:|.:|||....||.:||:|....|..:.:.::.|..:|.:||:|::.|.|.|.|:.|:|:
Human  1745 RDTGNIGQERVDTVNHLADELINSGHSDAATIAEWKDGLNEAWADLLELIDTRTQILAASYELHK 1809

  Fly  1981 FHRDVAEALFRIQDKNAALSQELGRDLNSALALLRKHEGFENDLVALEAQLQVLVEDSVRLQAKY 2045
            |:.|..|...|||||:..|.:|||||.|:...|.|.|..||:|:.||..|::.|.||:.||||.|
Human  1810 FYHDAKEIFGRIQDKHKKLPEELGRDQNTVETLQRMHTTFEHDIQALGTQVRQLQEDAARLQAAY 1874

  Fly  2046 PSN-ASAIAQQQDKVVAAWNDLKERSTARGDRLAASSDLQTFLTDVRDIVSWSSNLRAALQAEEH 2109
            ..: |..|.:::::|:.||..|.:...:|..||..:.|...|.:.|||::.|..::...::|:|.
Human  1875 AGDKADDIQKRENEVLEAWKSLLDACESRRVRLVDTGDKFRFFSMVRDLMLWMEDVIRQIEAQEK 1939

  Fly  2110 VSDAAGATALKIQHDAIYGEIEAREDKFRYLNELSDSMVQTGHYAAADVEEKCAAMLDERQKLHA 2174
            ..|.:....|...|..|..||:||.|.|....||..|::...|||:.:::||...:.::|:::..
Human  1940 PRDVSSVELLMNNHQGIKAEIDARNDSFTTCIELGKSLLARKHYASEEIKEKLLQLTEKRKEMID 2004

  Fly  2175 AWNKKKIMLEQKIDLFCFLRDAKQIDNLSSSQQAALSSSDFGQTVEDVQNKIRKHDEFERLIQTQ 2239
            .|..:...|...:::..|.|||...:.....|:..|||.:.||:|::|:..|::|:.||:...|.
Human  2005 KWEDRWEWLRLILEVHQFSRDASVAEAWLLGQEPYLSSREIGQSVDEVEKLIKRHEAFEKSAATW 2069

  Fly  2240 EEKVSLLQEHGRKLIEQRHYDSANIQTILQGVLARRQKVKDLCAVRRYKLEDALLYAKFVRDCAE 2304
            :|:.|.|:.                .|.|:.:..|||:.::   .|:.:........|...:...
Human  2070 DERFSALER----------------LTTLELLEVRRQQEEE---ERKRRPPSPEPSTKVSEEAES 2115

  Fly  2305 AKYWINEK-----QKKLEADAAS--YAEVTNLDEKIKKLQKHQ--------------------AF 2342
            .:.|...|     |..|.|:..|  .||..:..|.:....:.:                    |.
Human  2116 QQQWDTSKGEQVSQNGLPAEQGSPRMAETVDTSEMVNGATEQRTSSKESSPIPSPTSDRKAKTAL 2180

  Fly  2343 QAEVAAN-QGRIQE---IQDTGVILLSKQHESSPEIKRAIEIVLEAWQGLLAELEQRGRG----- 2398
            .|:.||. ..|.||   .|..|  .|:::||.....|:|..   .:|..:...:..:..|     
Human  2181 PAQSAATLPARTQETPSAQMEG--FLNRKHEWEAHNKKASS---RSWHNVYCVINNQEMGFYKDA 2240

  Fly  2399 ----------------LEEA--QDSLEFNSQLDKIEAWIRD-KEMMVQASDTGRDLEHCNALMRK 2444
                            |:||  :.:|::..:....:..:.| .|.:.||.|.    |..|..::.
Human  2241 KTAASGIPYHSEVPVSLKEAVCEVALDYKKKKHVFKLRLNDGNEYLFQAKDD----EEMNTWIQA 2301

  Fly  2445 LDD-VDSDMRVDDQRVKHINQLADKLINQAQVPADTQS 2481
            :.. :.||        ||            :|.|.|||
Human  2302 ISSAISSD--------KH------------EVSASTQS 2319

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
kstNP_001097492.2 CH_beta_spectrin_rpt1 61..176 CDD:409042 68/115 (59%)
CH_beta_spectrin_rpt2 196..302 CDD:409043 64/106 (60%)
SPEC 450..640 CDD:238103 66/196 (34%)
SPEC 658..832 CDD:238103 58/173 (34%)
SH3 885..935 CDD:214620 2/49 (4%)
SPEC 1030..1236 CDD:238103 50/210 (24%)
SPEC 1134..1341 CDD:238103 47/214 (22%)
SPEC 1343..1551 CDD:238103 53/211 (25%)
SPEC 1449..1658 CDD:238103 61/212 (29%)
SPEC 1555..1764 CDD:238103 60/209 (29%)
SPEC 1765..1975 CDD:238103 75/213 (35%)
SPEC 1873..2080 CDD:238103 82/211 (39%)
SPEC 1979..2185 CDD:238103 71/206 (34%)
SPEC 2188..2402 CDD:238103 53/265 (20%)
SPEC 2407..2618 CDD:238103 16/77 (21%)
SPEC 2514..2725 CDD:238103
SPEC 2726..2934 CDD:238103
SPEC 2935..3145 CDD:238103
SPEC 3042..3251 CDD:238103
SPEC 3149..3357 CDD:238103
SPEC 3359..3567 CDD:238103
SPEC 3465..3680 CDD:238103
PH_beta_spectrin 3801..3904 CDD:269975
SPTBN1NP_003119.2 Actin-binding 2..275 140/240 (58%)
CH_SPTBN1_rpt1 3..156 CDD:409165 68/115 (59%)
SAC6 48..>530 CDD:227401 248/487 (51%)
CH_SPTB_like_rpt2 173..277 CDD:409097 64/106 (60%)
Spectrin 1. /evidence=ECO:0000255 303..411 52/107 (49%)
Spectrin 2. /evidence=ECO:0000255 423..525 40/101 (40%)
SPEC 530..743 CDD:238103 72/212 (34%)
Spectrin 3. /evidence=ECO:0000255 530..636 34/105 (32%)
Spectrin 4. /evidence=ECO:0000255 639..742 34/102 (33%)
SPEC 642..849 CDD:238103 74/368 (20%)
Spectrin 5. /evidence=ECO:0000255 745..847 37/263 (14%)
Spectrin 6. /evidence=ECO:0000255 850..952 19/101 (19%)
SPEC 851..1061 CDD:238103 51/213 (24%)
Spectrin 7. /evidence=ECO:0000255 957..1060 28/106 (26%)
SPEC 958..1169 CDD:238103 48/215 (22%)
Spectrin 8. /evidence=ECO:0000255 1063..1166 17/103 (17%)
Spectrin 9. /evidence=ECO:0000255 1170..1258 17/87 (20%)
SPEC 1171..1380 CDD:238103 53/211 (25%)
Spectrin 10. /evidence=ECO:0000255 1276..1376 32/102 (31%)
SPEC 1381..1592 CDD:238103 60/211 (28%)
Spectrin 11. /evidence=ECO:0000255 1381..1482 26/101 (26%)
Spectrin 12. /evidence=ECO:0000255 1486..1590 32/103 (31%)
Interaction with ANK2. /evidence=ECO:0000269|PubMed:15262991 1563..2093 180/548 (33%)
SPEC 1593..1805 CDD:238103 76/214 (36%)
SPEC 1806..2027 CDD:238103 75/220 (34%)
Spectrin 2017..>2075 CDD:395348 18/57 (32%)
Spectrin 17. /evidence=ECO:0000255 2018..2097 25/97 (26%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2089..2196 20/109 (18%)
Mediates interaction with CAMSAP1. /evidence=ECO:0000269|PubMed:24117850 2149..2177 1/27 (4%)
PH_beta_spectrin 2200..2305 CDD:269975 19/113 (17%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2309..2364 8/31 (26%)
Blue background indicates that the domain is not in the aligned region.

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