Protein Alignment kst and ain1

DIOPT Version :10

• Sequence 1: NP_001097492.2
• Gene: kst / 38418
• FlyBaseID: FBgn0004167
• Length: 4337
• Species: Drosophila melanogaster
• Sequence 2: NP_594295.1
• Gene: ain1 / 2542805
• PomBaseID: SPAC15A10.08
• Length: 621
• Species: Schizosaccharomyces pombe
• Alignment Length: 727
• Identity: 213/727 - (29%)
• Similarity: 328/727 - (45%)
• Gaps: 160/727 - (22%)

  Fly    76 IQKKTFTKWMNSFLIKAKM-EVEDLFTDLADGIKLLKLLEIISSEKLGKPN-SGRMRVHKIENVN 138
            :|.:|||||.|:.|....: .|.||..||:|||.|::|||||..|.||:.| :.|||||::||||
pombe     9 VQNRTFTKWFNTKLSSRDLPSVFDLRKDLSDGILLIQLLEIIGDENLGRYNRNPRMRVHRLENVN 73

  Fly   139 KSLAFLHTK-VRLESIGAEDIVDGNPRLILGLIWTIILRFQIQEIEIDVDEENESSEKRSAKDAL 202
            |:|.::.:| :.|.:||..||||||.:||||||||:||||.|.:|       ||  |..:||:.|
pombe    74 KALEYIKSKGMPLTNIGPADIVDGNLKLILGLIWTLILRFTIADI-------NE--EGLTAKEGL 129

  Fly   203 LLWCQRKTHGY-PGVNITDFTNSWRSGLGFNALIHSHRPDLFEYSTIVNSKNSNLDNLNHAFDTA 266
            ||||||||..| |.|::.|||.||.:||.|.||||.|||||.:|:.:  .|.::..|:..|||.|
pombe   130 LLWCQRKTANYHPEVDVQDFTRSWTNGLAFCALIHQHRPDLLDYNKL--DKKNHRANMQLAFDIA 192

  Fly   267 ANELGIPSLLDAEDI-DSARPDEKSILTYVASYYHTFARMKNEQKSGKRIANIVGQLMDADRKKM 330
            ...:|||.|::.||: |..||||:||:||||.|:|.|:.:...:.:.:|:......||.....|:
pombe   193 QKSIGIPRLIEVEDVCDVDRPDERSIMTYVAEYFHAFSTLDKVETAARRVERFTEVLMSTHDMKI 257

  Fly   331 QYEGLTTNLLSWIRQ-----KTLELEQRDLPNSLEGIQRELLAFKEYRTIEKPPKYKERSEIEAL 390
            .||.....||..|.:     .|::.|     |:...::.....|.:::..||....||:.::|:|
pombe   258 DYESRMKRLLGSIARMQEYWHTVQFE-----NNYTDVKSHSNNFAKFKATEKREWVKEKIDLESL 317

  Fly   391 YFTINTLLKALNQPPYNPQDGQLVNDIEKAWQILEYAEHHREVALRDELLRQEKLEQLNYKFEKK 455
            ..||.|.||......|.|..|..:.|:|:.|:           ....|...|.||  :|
pombe   318 LGTIQTNLKTYQLRKYEPPAGLKIVDLERQWK-----------DFLSEEANQSKL--IN------ 363

  Fly   456 SVLREGYLKEMIQVLSDPRYLRQVDATLKKHEAISADILARVERFNDLTAMAEELDRE--NYHGK 518
                              .::|::..:::         :|..:|.|..:.|...:..|  |..|
pombe   364 ------------------THMREIKESMR---------IAFADRANSFSKMLSTISNEITNLQG- 400

  Fly   519 ERVRRREQEVMAKWRQLLELLENQRLNLSQMSNLMNLLREIASTTEAVRELQQQFASEDVGPHLL 583
                        .||..|:.:|                                |..|.:||  |
pombe   401 ------------DWRDQLDHVE--------------------------------FLQEHLGP--L 419

  Fly   584 GVEELLQAHSLQELQVNTYGETLKRFNRQALPYKSSEHK---DAALLAQRLADLEEAYSELLRRS 645
            .||    ..|::.|..|.:...::..:.....|:..||:   .|.::|.::..||....|..:|:
pombe   420 EVE----LASVKVLYDNCFQAGIEENDYTMFSYEDLEHEFGITANIIANKIKYLENELLEREKRT 480

  Fly   646 AARRARLEEARNFHHFMED--------------------YDNEE-SWLVDKQRICKTGITAKDLR 689
            .:::......:.|.||.:.                    ||.|| :.|..:....:.|:|.:...
pombe   481 LSKQELDGITKVFRHFEKKKSNMLNEVEFYAALASLGLVYDTEEGTALFHRAANSEEGVTYERFT 545

  Fly   690 AVLSLQQKHKALEDEIKSRKPKSGQMSTA-GKRLIGEQHPRSSEIQSRIDSLAE-----HWQALE 748
            .::.     :.|||...:|:........| ||..:.......|:::..|....|     |.:.|:
pombe   546 EIVM-----EELEDRDSARQVLYAFCDVADGKSYVTSDDLLRSQVRPNIVKFLECNMNKHSEGLD 605

  Fly   749 ALVELRRRQLED 760
            .|..:::...||
pombe   606 YLTWIKQLLAED 617

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
kst	NP_001097492.2	CH_beta_spectrin_rpt1	61..176	CDD:409042	56/102 (55%)
		CH_beta_spectrin_rpt2	196..302	CDD:409043	57/107 (53%)
		SPEC	450..640	CDD:238103	29/194 (15%)
		SPEC	658..832	CDD:238103	25/130 (19%)
		SH3	885..935	CDD:214620
		SPEC	1030..1236	CDD:238103
		SPEC	1134..1341	CDD:238103
		SPEC	1343..1551	CDD:238103
		SPEC	1449..1658	CDD:238103
		SPEC	1555..1764	CDD:238103
		SPEC	1765..1975	CDD:238103
		SPEC	1873..2080	CDD:238103
		SPEC	1979..2185	CDD:238103
		SPEC	2188..2402	CDD:238103
		SPEC	2407..2618	CDD:238103
		SPEC	2514..2725	CDD:238103
		SPEC	2726..2934	CDD:238103
		SPEC	2935..3145	CDD:238103
		SPEC	3042..3251	CDD:238103
		SPEC	3149..3357	CDD:238103
		SPEC	3359..3567	CDD:238103
		SPEC	3465..3680	CDD:238103
		PH_beta_spectrin	3801..3904	CDD:269975
ain1	NP_594295.1	SAC6	1..616	CDD:227401	211/724 (29%)