DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment kst and EHBP1

DIOPT Version :9

Sequence 1:	NP_001097492.2	Gene:	kst / 38418	FlyBaseID:	FBgn0004167	Length:	4337	Species:	Drosophila melanogaster
Sequence 2:	NP_001341141.1	Gene:	EHBP1 / 23301	HGNCID:	29144	Length:	1231	Species:	Homo sapiens

Alignment Length:	867	Identity:	188/867 - (21%)
Similarity:	322/867 - (37%)	Gaps:	274/867 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   195 KRSAKDALLLWCQRKTHGYPGVNITDFTNSWRSGLGFNALIHSHRPDLFEYSTIVNSKNSNLDNL 259
            |.:|..:||:||:..|..|.||.||:||.|||:||.|.|::|..||||.:|.:: |.::.. :|.
Human   442 KPNASQSLLVWCKEVTKNYRGVKITNFTTSWRNGLSFCAILHHFRPDLIDYKSL-NPQDIK-ENN 504

  Fly   260 NHAFDTAANELGIPSLLDAED-IDSARPDEKSILTYVASYYHTFARM--------KNEQKSGKRI 315
            ..|:|..|: :||..||:..| :..|.||:.:::||:......|:..        :|..||..::
Human   505 KKAYDGFAS-IGISRLLEPSDMVLLAIPDKLTVMTYLYQIRAHFSGQELNVVQIEENSSKSTYKV 568

  Fly   316 ANIVGQLMDADRKKMQYEGLTTNLLSWIRQKTLELEQRDLPNSLEGIQRELLAFKEYRTIEKPPK 380
            .|              ||   |:..|.:.|:....|..||....| :|:.:....::.:.:....
Human   569 GN--------------YE---TDTNSSVDQEKFYAELSDLKREPE-LQQPISGAVDFLSQDDSVF 615

  Fly   381 YKER--SEIEALYFTINTLLKALNQPPY--------NPQDGQLVN---------------DIEKA 420
            ..:.  .|.|:.:.|.:..|......||        .||..|..:               |..:|
Human   616 VNDSGVGESESEHQTPDDHLSPSTASPYCRRTKSDTEPQKSQQSSGRTSGSDDPGICSNTDSTQA 680

  Fly   421 WQILEYAEHHREVALRDELLRQEKLEQLN-YKFEKKSVLREGYL-----KEMIQVL--------- 470
            ..:|.          :..||:.|.||..: |..:||..:...::     ::.:|.|
Human   681 QVLLG----------KKRLLKAETLELSDLYVSDKKKDMSPPFICEETDEQKLQTLDIGSNLEKE 735

  Fly   471 -----------SDPR-----------------YLRQVDATLKKHEAISADILARVERFNDLTAMA 507
                       |||.                 |.|.:|...|||.:     |.:.|  :|..|..
Human   736 KLENSRSLECRSDPESPIKKTSLSPTSKLGYSYSRDLDLAKKKHAS-----LRQTE--SDPDADR 793

  Fly   508 EELDRENYHGK---ERVRRREQEVMAKWRQLLE-------LLENQRLNLSQMSNLMNLLREIAST 562
            ..|:..::..|   .|:..|::|:..:.|.|||       |....:.|.:..:...|  |:::..
Human   794 TTLNHADHSSKIVQHRLLSRQEELKERARVLLEQARRDAALKAGNKHNTNTATPFCN--RQLSDQ 856

  Fly   563 TEAVRELQ-QQFASEDVGPHLLGVE--EL-----LQAHSLQE-----------LQVNTYGETLKR 608
            .:..|..| ::.|.:.:.....||:  ||     :.|..|:|           ::::|..|..:.
Human   857 QDEERRRQLRERARQLIAEARSGVKMSELPSYGEMAAEKLKERSKASGDENDNIEIDTNEEIPEG 921

  Fly   609 F------------NRQALPYKSSEHKDAALLAQRLADLEEAYSELLR--RSAARRARLEEA-RNF 658
            |            |....|.::|:     |:..:|..|.|...::..  .|||::|..|.: ::.
Human   922 FVVGGGDELTNLENDLDTPEQNSK-----LVDLKLKKLLEVQPQVANSPSSAAQKAVTESSEQDM 981

  Fly   659 HHFMEDYDNEESWLVDKQRICKTG-------ITAKD--------------------LRAVLSLQQ 696
            ....||...|        |:.||.       :.:||                    ::...|:|:
Human   982 KSGTEDLRTE--------RLQKTTERFRNPVVFSKDSTVRKTQLQSFSQYIENRPEMKRQRSIQE 1038

  Fly   697 KHKALEDEIKS-----RKPKSGQMSTAG-----KRLIGEQHPRSSEIQSRIDSLAEHWQALEALV 751
            ..|...:|..:     |||...::...|     :.::||.....:| |.:||:.|       |||
Human  1039 DTKKGNEEKAAITETQRKPSEDEVLNKGFKDTSQYVVGELAALENE-QKQIDTRA-------ALV 1095

  Fly   752 ELRRRQLEDAAEAYQFYTDANEAESWLNEKIALVNSRDYGNDEPSAQALLQRHRDLQGELNAYSG 816
            |.|.|.|.|...      :..|.|:.:.|...|||.::......:..:||::..||:...
Human  1096 EKRLRYLMDTGR------NTEEEEAMMQEWFMLVNKKNALIRRMNQLSLLEKEHDLERRY----- 1149

  Fly   817 DILNLNQQA---------------------DKLI----KAGICTLELSAAEPELPEVEQEEWVNE 856
            ::||...:|                     |:|:    |......:|.|.|.:..|
Human  1150 ELLNRELRAMLAIEDWQKTEAQKRREQLLLDELVALVNKRDALVRDLDAQEKQAEE--------- 1205

  Fly   857 TRLVPKEVWEDEWVEK-LEHKK 877
                     |||.:|: ||..|
Human  1206 ---------EDEHLERTLEQNK 1218

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kst	NP_001097492.2	CH	76..178	CDD:237981
		CH	197..303	CDD:237981	41/106 (39%)
		SPEC	450..640	CDD:238103	51/272 (19%)
		SPEC	658..832	CDD:238103	47/235 (20%)
		SH3	885..935	CDD:214620
		SPEC	1030..1236	CDD:238103
		SPEC	1134..1341	CDD:238103
		SPEC	1343..1551	CDD:238103
		SPEC	1449..1658	CDD:238103
		SPEC	1555..1764	CDD:238103
		SPEC	1765..1975	CDD:238103
		SPEC	1873..2080	CDD:238103
		SPEC	1979..2185	CDD:238103
		SPEC	2188..2402	CDD:238103
		SPEC	2407..2618	CDD:238103
		SPEC	2514..2725	CDD:238103
		SPEC	2726..2934	CDD:238103
		SPEC	2935..3145	CDD:238103
		SPEC	3042..3251	CDD:238103
		SPEC	3149..3357	CDD:238103
		SPEC	3359..3567	CDD:238103
		SPEC	3465..3680	CDD:238103
		PH	3799..3902	CDD:278594
		PH_beta_spectrin	3801..3904	CDD:269975
EHBP1	NP_001341141.1	NT-C2	12..165	CDD:313563
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	264..318
		NPF	<274..383	CDD:318744
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	358..440
		CH	447..549	CDD:306753	41/104 (39%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	616..675		9/58 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	737..764		3/26 (12%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	777..800		8/29 (28%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	837..865		4/29 (14%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	895..941		6/45 (13%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	960..996		9/43 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1025..1065		7/39 (18%)
		DUF3585	1074..1210	CDD:314926	38/172 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1198..1231		10/39 (26%)
		CAAX motif. /evidence=ECO:0000305\|PubMed:27552051	1228..1231
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910