DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment kst and Sptbn2

DIOPT Version :10

Sequence 1:NP_001097492.2 Gene:kst / 38418 FlyBaseID:FBgn0004167 Length:4337 Species:Drosophila melanogaster
Sequence 2:NP_067262.1 Gene:Sptbn2 / 20743 MGIID:1313261 Length:2388 Species:Mus musculus


Alignment Length:2591 Identity:787/2591 - (30%)
Similarity:1257/2591 - (48%) Gaps:333/2591 - (12%)


- Green bases have known domain annotations that are detailed below.


  Fly    61 FENERIKTLQEERLHIQKKTFTKWMNSFLIKAKMEVEDLFTDLADGIKLLKLLEIISSEKLGKPN 125
            ||..|||.|.:||..:||||||||:||.|.:....|.||::||.||..||:|||::|.|.|.||.
Mouse    43 FERSRIKALADEREAVQKKTFTKWVNSHLARVTCRVGDLYSDLRDGRNLLRLLEVLSGETLPKPT 107

  Fly   126 SGRMRVHKIENVNKSLAFL-HTKVRLESIGAEDIVDGNPRLILGLIWTIILRFQIQEIEIDVDEE 189
            .||||:|.:|||:|:|.|| ..||.||::|:.||||||.||.|||:||||||||||:|.:   |.
Mouse   108 KGRMRIHCLENVDKALQFLKEQKVHLENMGSHDIVDGNHRLTLGLVWTIILRFQIQDISV---ET 169

  Fly   190 NESSEKRSAKDALLLWCQRKTHGYPGVNITDFTNSWRSGLGFNALIHSHRPDLFEYSTIVNSKNS 254
            .::.||:|||||||||||.||.|||.||:.:||.|||.||.|||::|.|||||.::.::   |..
Mouse   170 EDNKEKKSAKDALLLWCQMKTAGYPNVNVHNFTTSWRDGLAFNAIVHKHRPDLLDFESL---KKC 231

  Fly   255 NLD-NLNHAFDTAANELGIPSLLDAEDIDSARPDEKSILTYVASYYHTFARMKNEQKSGKRIANI 318
            |.. ||.:||:.|..|||:..|||.||::..:||||||:||||:|||.|::||.....||||..:
Mouse   232 NAHYNLQNAFNLAEKELGLTKLLDPEDVNVDQPDEKSIITYVATYYHYFSKMKALAVEGKRIGKV 296

  Fly   319 VGQLMDADRKKMQYEGLTTNLLSWIRQKTLELEQRDLPNSLEGIQRELLAFKEYRTIEKPPKYKE 383
            :...|:|:....:||.|.:.||.||.|..:.|..|.|.|||.|:|.:|.:|..|||:|||||:.|
Mouse   297 LDHAMEAEHLVEKYESLASELLQWIEQTIVTLNDRQLANSLSGVQNQLQSFNSYRTVEKPPKFTE 361

  Fly   384 RSEIEALYFTINTLLKALNQPPYNPQDGQLVNDIEKAWQILEYAEHHREVALRDELLRQEKLEQL 448
            :..:|.|.|||.:.|:|.||..|.|::|:|::||.|||:.||.|||.||:|||.||:||||||||
Mouse   362 KGNLEVLLFTIQSKLRANNQKVYTPREGRLISDINKAWERLEKAEHERELALRTELIRQEKLEQL 426

  Fly   449 NYKFEKKSVLREGYLKEMIQVLSDPRY---LRQVDATLKKHEAISADILARVERFNDLTAMAEEL 510
            ..:|::|:.:||.:|.|..:::|...:   |..|:|.::|||||..||:|...|...:.|:|.||
Mouse   427 AARFDRKAAMRETWLSENQRLVSQDNFGLELAAVEAAVRKHEAIETDIVAYSGRVQAVDAVAAEL 491

  Fly   511 DRENYHGKERVRRREQEVMAKWRQLLELLENQRLNLSQMSNLMNLLREIASTTEAVRELQQQFAS 575
            ..|:||..:|:..|:..|...|..|.:::..:|..|.....|..:.:::....:.:.|::.:..|
Mouse   492 AAEHYHDIKRIAARQNNVARLWDFLRQMVAARRERLLLNLELQKVFQDLLYLMDWMAEMKGRLQS 556

  Fly   576 EDVGPHLLGVEELLQAHSLQELQVNTYGETLKRFNRQAL----PYKSSEHKDAALLAQRLADLEE 636
            :|:|.||.|||:|||.|.|.|..:....|.::..:..||    |.|.....|..|:::|:|.||:
Mouse   557 QDLGKHLAGVEDLLQLHELVEADIAVQAERVRAVSASALRFCDPGKEYRPCDPQLVSERVATLEQ 621

  Fly   637 AYSELLRRSAARRARLEEARNFHHFMEDYDNEESWLVDKQRICKTGITAKDLRAVLSLQQKHKAL 701
            :|..|...:|.|||||||:|....|:.:....|:|:.::|.:..:..|.:||..||.|..||.||
Mouse   622 SYEALCELAATRRARLEESRRLWRFLWEVGEAEAWVREQQHLLASADTGRDLTGVLRLLNKHAAL 686

  Fly   702 EDEIKSRKPKSGQMSTAGKRLIGEQHPRSSEIQSRIDSLAEHWQALEALVELRRRQLEDAAEAYQ 766
            ..|:..|..........|::|:.|.||.:::..:|...|...|:.||||.|.|.:||..||..||
Mouse   687 RGEMSGRLGPLKLTLEQGQQLVAEGHPGANQASTRAAELQAQWERLEALAEERAQQLAQAASLYQ 751

  Fly   767 FYTDANEAESWLNEKIALVNSRDYGNDEPSAQALLQRHRDLQGELNAYSGDILNLNQQADKLIKA 831
            |..|||:.|:||.:.:.||:|.:.|:||.|.|||.::||.|:.|:.|:...:..|.:||..|   
Mouse   752 FQADANDMEAWLVDALRLVSSPEVGHDEFSTQALARQHRALEEEIRAHRPTLDALREQAAAL--- 813

  Fly   832 GICTLELSAAEPELPEVEQEEWVNETRLVPKEVWEDEWVEKLEHKKVTETKMLPHVKSLFPFEGQ 896
                                                                             
Mouse   814 ----------------------------------------------------------------- 813

  Fly   897 GMKMDKGEVMLLKSKTNDDWWCVRKDNGVEGFVPANYVREVEPRPVACIVPKAEKVKSLQKVKKT 961
                                                                             
Mouse   814 ----------------------------------------------------------------- 813

  Fly   962 ILVRQVVPVKRIKPVSVAPKPLVQRRTSTQSINENADSVEKRQQRINQTYDELQEMAQKRHALLE 1026
                         |.:::..|.||.|..|                :.|.|:|||..|.:|...||
Mouse   814 -------------PPALSHTPEVQGRVPT----------------LEQHYEELQARAGERARALE 849

  Fly  1027 DSIHLFGFYRECDDFEKWMKEKERMIKS----DEGEGVDNAKRKFEKFITDLSAASKRVEEIDGA 1087
            .::..:....|......|::|||:.:..    :..|.::..:::||....:::|.:.||..::..
Mouse   850 AALAFYTMLSEAGACGLWVEEKEQWLNGLALPERLEDLEVVQQRFETLEPEMNALAARVTAVNDI 914

  Fly  1088 VDTFRRQGHSQLDKIIARQRQIHQIWQRLNNAKAQREKSLEGASSVELFNRTCDEAKVWMSEKML 1152
            .:...:......|:||..|.|::|.||:..:....::.:|..|.|::.::..|.|.:.||.||..
Mouse   915 AEQLLKASPPGKDRIIGTQEQLNQRWQQFRSLADGKKAALTSALSIQNYHLECTETQAWMREKTK 979

  Fly  1153 QLD-TAVITPDLRTVQALQRRHQNLERELAPVEDKVNRVTYLGNSVKNAYPAEKDNVNARQQEVQ 1216
            .:: |..:..||..|.||||:....||:|..:..:|..:|...|::...:||:...:|.|..|||
Mouse   980 VIESTQGLGNDLAGVLALQRKLAGTERDLEAISARVGELTQEANALAAGHPAQAPAINTRLGEVQ 1044

  Fly  1217 DMWQQVQQRGSDLRNRIESEVGQ----QVFNNSAKVLLAWIDSVKDQLNADESARDVETANNLLK 1277
            ..|:.::   :.:|.|.|| :|:    |.|..|.....||:...:..:.::|....:..|..||.
Mouse  1045 AGWEDLR---ATMRRREES-LGEARRLQDFLRSLDDFQAWLGRTQTAVASEEGPATLPEAEALLA 1105

  Fly  1278 KHNDLGDDIRAHDTEFVEVIQLGKQLS--DGKPNMAETVAVIERLKAEQDAIHRGWAEKQKWLLQ 1340
            :|..|..::....:|:..:..||::::  ...|........:|.|....:.:.|.|..:|..|.|
Mouse  1106 QHAALRGEVERAQSEYSRLRTLGEEVTRDQADPQCLFLRQRLEALGTGWEELGRMWESRQGRLAQ 1170

  Fly  1341 CVDLQMFNREADKIDATTKSHEAFLEYNNLGASLDEVEAILKRHLDFEKSLMAQDKILKGFSDNA 1405
            ....|.|.|:|.:.:....|.|..|.:..:..:|...:|.:|:..||..::.|..:.::|..:..
Mouse  1171 AHGFQGFLRDARQAEGVLSSQEYVLSHTEMPGTLQAADAAIKKLEDFMSTMDANGERIRGLLEAG 1235

  Fly  1406 DKLISNDHYDSKYIGDRRNQVLGKRKAVKDRAFERKRLLQASKDFHKFAAEADDLKVWLQDKTRI 1470
            .:|:|..:..::.|.::.:.:..:.:..::...:....|:.:::...|..:..:|::|:.:|...
Mouse  1236 RQLVSKGNIHAEKIQEKADSIEKRHRKNQEAVQQLLGRLRDNREQQHFLQDCQELRLWIDEKMLT 1300

  Fly  1471 AGDENYRDLSNLPRKLQKHQAFERELRANEGQLRNVTKDGQALVQAGNRVPE----VESRVADLN 1531
            |.|.:|.:..||..|.||||||..||.||:..|..|.|:|:.|..   ..||    |..::.||:
Mouse  1301 AQDVSYDEARNLHTKWQKHQAFMAELAANKDWLDKVDKEGRELTL---EKPELKVVVSEKLEDLH 1362

  Fly  1532 KRWKDLLTLSEDKGRKLEQAASQREHNRSLEDAKKKVDELDSALRSGDVGNDLRSCKDLINKQQI 1596
            :||.:|.|.::.|.|.|..|.......:|....:..::.|.:.|.|.|.|.||.|...|:.|||:
Mouse  1363 RRWDELETTTQAKARSLFDANRAELFAQSCSALESWLESLQAQLHSDDYGKDLTSVNILLKKQQM 1427

  Fly  1597 LESEITIWDQKVAELVSTGDDMAHGGHFNAQNIEAGTKELQQRFKDLRDPTQRRRAKLEESLNYH 1661
            ||.|:.:.:::|..:.:....:|.... :|..:|..::.::::|:.|..|.:.|..:|..|...|
Mouse  1428 LEREMAVREKEVEAIQAQAQALAQEDQ-SAGEVERTSRAVEEKFRALCQPMKERCRRLHASREQH 1491

  Fly  1662 KFVFELDSEFQWINEHLPAAKSNELGQNLHQAQSLHKKHKKLEAEIKGHQPMINKALVAGQSL-I 1725
            :|..:::.|..|:.|.||.|.|.|.|::|...|.|.||::.|:.||:||:|.|.......::| .
Mouse  1492 QFHRDVEDEILWVTERLPMASSLEHGKDLPSVQLLMKKNQTLQKEIQGHEPRIADLKERQRTLGT 1556

  Fly  1726 SQQHPEREQVESLCQQLEQAWQDLERHCGERSRKLDMSLKAQQYLFDAGEIESWLGERNNVLRST 1790
            :...||       ..:|::.|:.|......|.::|:.:|:|||:..||.|.|:|:||:...:...
Mouse  1557 AAAGPE-------LAELQEMWKRLSHELELRGKRLEEALRAQQFYRDAAEAEAWMGEQELHMMGQ 1614

  Fly  1791 EYGRDRDSAAKLLTKHKTIELELDTYSGIVTEMGHSCAAMVAANHPDSKVLAAKQQLIEKMLKSL 1855
            |..:|..||...:.||:.:|..|..|:..:.::..|...|:...||:|..|..:|..::|:..||
Mouse  1615 EKAKDELSAQAEVKKHQVLEQALADYAQTIKQLAASSQDMIDHEHPESTRLTIRQAQVDKLYASL 1679

  Fly  1856 HKLASQRQGRLMESLYKHEYFLESDEVEQWIREQEQAASSEDYGQDFEHLQLLQNKFDDL-KHRV 1919
            .:||.:|:.||.|.|...:...|.|::||||:|:|..|:|.:.|||:||:.:|::||.:. |...
Mouse  1680 KELAGERRERLQEHLRLCQLRRELDDLEQWIQEREVVAASHELGQDYEHVTMLRDKFREFSKDTS 1744

  Fly  1920 EVGADRVDQCELLAKKLIDSESPYANEVEKRQEQLRTSWENLLQLLNQREQKLHAAGEIHRFHRD 1984
            .:|.:|||....||..||.........|.:.::.|..:|.:||:||:.|.|.|.||.|:.||...
Mouse  1745 TIGQERVDSANALANGLIAGGHAARATVAEWKDSLNEAWADLLELLDTRGQVLAAAYELQRFLHG 1809

  Fly  1985 VAEALFRIQDKNAALSQELGRDLNSALALLRKHEGFENDLVALEAQLQVLVEDSVRLQAKYPSN- 2048
            ..:||.|:|.|...|....|||||:|.||.|:|..:|:|:.||..|:|.:.:|..|||..|..: 
Mouse  1810 ARQALARVQHKQQQLPDGTGRDLNAAEALQRRHCAYEHDIQALSTQVQQVQDDGQRLQKAYAGDK 1874

  Fly  2049 ASAIAQQQDKVVAAWNDLKERSTARGDRLAASSDLQTFLTDVRDIVSWSSNLRAALQAEEHVSDA 2113
            |..|.:....|..||..|:..|.||...|..::|...|...||:::.|...:...:.|:|...|.
Mouse  1875 AEEIGRHMQAVAEAWAQLQGSSAARRQLLLDTTDKFRFFKAVRELMLWMDGINLQMDAQERPRDV 1939

  Fly  2114 AGATALKIQHDAIYGEIEAREDKFRYLNELSDSMVQTGHYAAADVEEKCAAMLDERQKLHAAWNK 2178
            :.|..:......|..|||||.|:|....::...::...||||.::.||.:.:...||:....|.:
Mouse  1940 SSADLVIKNQQGIKAEIEARADRFSSCIDMGQELLARSHYAAEEISEKLSQLQSRRQETADKWQE 2004

  Fly  2179 KKIMLEQKIDLFCFLRDAKQIDNLSSSQQAALSSSDFGQTVEDVQNKIRKHDEFERLIQTQEEKV 2243
            |...|:..:::..|.|||...:....||:..:.|::.|.||::|::.|::|:.|::.....||:.
Mouse  2005 KMDWLQLVLEVLVFGRDAGMAEAWLCSQEPLVRSAELGCTVDEVESLIKRHEAFQKSAVAWEERF 2069

  Fly  2244 SLLQ----------EHGRKLIEQRHYDSANIQTILQGVLARRQKVKDLCAVRRYKLEDALLYAKF 2298
            |.|:          |..||..|:                 .|:|..........:.|.:|:..:.
Mouse  2070 SALEKLTALEERENERKRKREEE-----------------ERRKQPPTSEPMASQPEGSLVDGQR 2117

  Fly  2299 VRDCAEAKYWINEKQKKL--EADAASYAEV-TNLDEKIKKLQKHQAFQAEVAANQGRIQEIQDTG 2360
            |.|.|    | :..|.||  ...|.|...| |:.|.....|::.:..|:.|....|     ..||
Mouse  2118 VPDTA----W-DGTQSKLPPSTQAPSVNGVCTDTDSSQPLLEQQRLEQSNVPEGPG-----SGTG 2172

  Fly  2361 VILLSKQHESS------------------PEIKRAIEIVLEAWQGLLAELEQRGRGLEEAQDSLE 2407
                   .|||                  |:.:.:     ||..|  |.|..||..| .||:.:|
Mouse  2173 -------DESSGPRGERQTLPRGPAPSPMPQSRSS-----EAAHG--ATLPTRGPEL-SAQEQME 2222

  Fly  2408 -----------FNSQLDKIEAWIRDKEMMVQASDTG--RDLEHCNA-----------LMRKLDDV 2448
                       ||.:... .:| ::...:::....|  :|....:|           |.|....|
Mouse  2223 GMLCRKQEMEAFNKKAAN-RSW-QNVYCVLRRGSLGFYKDARAASAGVPYHGEVPVSLARAQGSV 2285

  Fly  2449 DSDMRVDDQRVKHINQL----ADKLINQAQVPADTQSVDKRRKDFNYNWRQLQGALNAYRALLGG 2509
            ..|.|    :.||:.:|    ..:.:.||:..|:..|           |.::..|..|..:...|
Mouse  2286 AFDYR----KRKHVFKLGLQDGKEYLFQAKDEAEMSS-----------WLRVVNAAIATASSAPG 2335

  Fly  2510 ANEIHVFNRDVDDTADRIAEKSLAMSSTDTGRDLAAVEALIRREEALERDMSAVKQ 2565
            .:|     ..|..:|.|...:::.|...........:.:...||...|:..|..|:
Mouse  2336 ESE-----EPVVPSASRGLTRAMTMPPVSQPEGSIVLRSKDGREREREKRFSFFKK 2386

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
kstNP_001097492.2 CH_beta_spectrin_rpt1 61..176 CDD:409042 68/115 (59%)
CH_beta_spectrin_rpt2 196..302 CDD:409043 62/106 (58%)
SPEC 450..640 CDD:238103 61/196 (31%)
SPEC 658..832 CDD:238103 62/173 (36%)
SH3 885..935 CDD:214620 0/49 (0%)
SPEC 1030..1236 CDD:238103 53/210 (25%)
SPEC 1134..1341 CDD:238103 54/213 (25%)
SPEC 1343..1551 CDD:238103 55/211 (26%)
SPEC 1449..1658 CDD:238103 63/212 (30%)
SPEC 1555..1764 CDD:238103 57/209 (27%)
SPEC 1765..1975 CDD:238103 73/210 (35%)
SPEC 1873..2080 CDD:238103 79/208 (38%)
SPEC 1979..2185 CDD:238103 67/206 (33%)
SPEC 2188..2402 CDD:238103 56/244 (23%)
SPEC 2407..2618 CDD:238103 33/187 (18%)
SPEC 2514..2725 CDD:238103 9/52 (17%)
SPEC 2726..2934 CDD:238103
SPEC 2935..3145 CDD:238103
SPEC 3042..3251 CDD:238103
SPEC 3149..3357 CDD:238103
SPEC 3359..3567 CDD:238103
SPEC 3465..3680 CDD:238103
PH_beta_spectrin 3801..3904 CDD:269975
Sptbn2NP_067262.1 CH_SPTB-like_rpt1 43..159 CDD:409095 68/115 (59%)
CH_SPTBN2_rpt2 173..291 CDD:409170 67/120 (56%)
Spectrin 305..414 CDD:395348 53/108 (49%)
Spectrin 429..522 CDD:395348 31/92 (34%)
SPEC 534..746 CDD:238103 69/211 (33%)
SPEC 749..958 CDD:238103 63/370 (17%)
SPEC 961..1172 CDD:238103 55/214 (26%)
SPEC 1174..1383 CDD:238103 55/211 (26%)
SPEC 1384..1588 CDD:238103 57/211 (27%)
SPEC 1589..1801 CDD:238103 74/211 (35%)
SPEC 1802..2010 CDD:238103 67/207 (32%)
SPEC 2018..>2075 CDD:197544 18/56 (32%)
PH_beta_spectrin 2221..2326 CDD:269975 20/121 (17%)
Blue background indicates that the domain is not in the aligned region.

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