DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment kst and Sptb

DIOPT Version :10

Sequence 1:NP_001097492.2 Gene:kst / 38418 FlyBaseID:FBgn0004167 Length:4337 Species:Drosophila melanogaster
Sequence 2:NP_038703.3 Gene:Sptb / 20741 MGIID:98387 Length:2329 Species:Mus musculus


Alignment Length:2216 Identity:677/2216 - (30%)
Similarity:1149/2216 - (51%) Gaps:213/2216 - (9%)


- Green bases have known domain annotations that are detailed below.


  Fly    61 FENERIKTLQEERLHIQKKTFTKWMNSFLIKAKMEVEDLFTDLADGIKLLKLLEIISSEKLGKPN 125
            ||..|||.|.:||..:||||||||:||.|.:....:.||:.||.||..|:||||::|.|.|.:|.
Mouse    40 FERSRIKALADEREVVQKKTFTKWVNSHLARVSCRISDLYKDLRDGRMLIKLLEVLSGEMLPRPT 104

  Fly   126 SGRMRVHKIENVNKSLAFL-HTKVRLESIGAEDIVDGNPRLILGLIWTIILRFQIQEIEIDVDEE 189
            .|:||:|.:|||:|:|.|| ..:|.||::|:.||||||.||:||||||||||||||:|   |.:.
Mouse   105 KGKMRIHCLENVDKALQFLKEQRVHLENMGSHDIVDGNHRLVLGLIWTIILRFQIQDI---VVQT 166

  Fly   190 NESSEKRSAKDALLLWCQRKTHGYPGVNITDFTNSWRSGLGFNALIHSHRPDLFEYSTIVNSKNS 254
            .|..|.||||||||||||.||.|||.||:|:||:||:.||.||||||.|||||.::..:   |:|
Mouse   167 QEGRETRSAKDALLLWCQMKTAGYPHVNVTNFTSSWKDGLAFNALIHKHRPDLIDFDKL---KDS 228

  Fly   255 NL-DNLNHAFDTAANELGIPSLLDAEDIDSARPDEKSILTYVASYYHTFARMKNEQKSGKRIANI 318
            |. .||.||||.|..:|||..|||.||:.:..||||||:|||.::||.|::||.....|||:..:
Mouse   229 NARHNLEHAFDVAERQLGIIPLLDPEDVFTENPDEKSIITYVVAFYHYFSKMKVLAVEGKRVGKV 293

  Fly   319 VGQLMDADRKKMQYEGLTTNLLSWIRQKTLELEQRDLPNSLEGIQRELLAFKEYRTIEKPPKYKE 383
            :...::.::...:|.||.::||:||.|....|..|...|||.|:|::|.||..|||:|||||::|
Mouse   294 IDHAIETEKMIEKYSGLASDLLTWIEQTISVLNSRKFANSLSGVQQQLQAFSTYRTVEKPPKFQE 358

  Fly   384 RSEIEALYFTINTLLKALNQPPYNPQDGQLVNDIEKAWQILEYAEHHREVALRDELLRQEKLEQL 448
            :..:|.|.|||.:.::|.||..|.|.||:||:||.:||:.||.||:.||:|||.||:||||||||
Mouse   359 KGNLEVLLFTIQSRMRANNQKVYTPHDGKLVSDINRAWESLEEAEYQRELALRSELIRQEKLEQL 423

  Fly   449 NYKFEKKSVLREGYLKEMIQVLSDPRY---LRQVDATLKKHEAISADILARVERFNDLTAMAEEL 510
            ..:|::|:.:||.:|.|..::::...:   |..|:|..||||||..|..|..||...|..:|:||
Mouse   424 ARRFDRKAAMRETWLNENQRLVTQDNFGYDLAAVEAAKKKHEAIETDTAAYEERVKALEDLAQEL 488

  Fly   511 DRENYHGKERVRRREQEVMAKWRQLLELLENQRLNLSQMSNLMNLLREIASTTEAVRELQQQFAS 575
            ::||||.::|:..|:..::..|..|.|||.::|..|.....|..|.:::..:.:.:.|::....|
Mouse   489 EKENYHDQKRIIARKDNILRLWSYLQELLRSRRQRLEATLALQKLFQDMLHSIDWMDEIKAHILS 553

  Fly   576 EDVGPHLLGVEELLQAHSLQELQVNTYGETLKRFNRQALPY---KSSEHKDAALLAQRLADLEEA 637
            .:.|.|||.||:|||.|.|.|..:...|:.:|......|.:   |..:..|..::..|::.||:.
Mouse   554 AEFGKHLLEVEDLLQKHKLMEADIAIQGDKVKAITAATLQFAEGKGYQPCDPQVIQDRVSHLEQC 618

  Fly   638 YSELLRRSAARRARLEEARNFHHFMEDYDNEESWLVDKQRICKTGITAKDLRAVLSLQQKHKALE 702
            :|||...:|.|:|:||:::....|..:.|..|||:.:|::|..:....|||.:||.||:||||.|
Mouse   619 FSELSNMAAGRKAQLEQSKRLWKFFWEMDEAESWIKEKEQIYSSLDYGKDLTSVLILQRKHKAFE 683

  Fly   703 DEIKSRKPKSGQMSTAGKRLIGEQ---HPRSSEIQSRIDSLAEHWQALEALVELRRRQLEDAAEA 764
            ||::.......|:......::.::   ||   :|::|:..::..|..|:.|...|::.|:||...
Mouse   684 DELRGLDAHLKQIFQEADDMVAQKQFGHP---QIETRVKEVSAQWDHLKELAAFRKKDLQDAENF 745

  Fly   765 YQFYTDANEAESWLNEKIALVNSRDYGNDEPSAQALLQRHRDLQGELNAYSGDILNLNQQADKLI 829
            :||..||::.::||.:...|::..|.|.||.:.:||.::|::.                      
Mouse   746 FQFQGDADDLKAWLQDAHRLLSGEDVGQDEGATRALGKKHKEF---------------------- 788

  Fly   830 KAGICTLELSAAEPELPEVEQEEWVNETRLVPKEVWEDEWVEKLEHKKVTETKMLPHVKSLFPFE 894
                           |.|:|:...|               :|.|||:                  
Mouse   789 ---------------LEELEESRGV---------------MEHLEHQ------------------ 805

  Fly   895 GQGMKMDKGEVMLLKSKTNDDWWCVRKDNGVEGFVPANYVREVEPRPVACIVPKAEKVKSLQKVK 959
                                          .:|| |..:                          
Mouse   806 ------------------------------AQGF-PEEF-------------------------- 813

  Fly   960 KTILVRQVVPVKRIKPVSVAPKPLVQRRTSTQSINENADSVEKRQQRINQTYDELQEMAQKRHAL 1024
                                               .::..|..|.|.:.:.|.::...|:.|...
Mouse   814 -----------------------------------RDSPDVTNRLQALRKLYQQVLTQAELRGHK 843

  Fly  1025 LEDSIHLFGFYRECDDFEKWMKEK----ERMIKSDEGEGVDNAKRKFEKFITDLSAASKRVEEID 1085
            |::::.|:..:.|.|..|.||.||    ::|...:..|.::..:.:|:....::.....:::.::
Mouse   844 LQEALDLYTVFGESDACELWMTEKGKWLDQMDIPNTLEDLEVVQHRFDILDQEMKTLMAQIDGVN 908

  Fly  1086 GAVDTFRRQGHSQLDKIIARQRQIHQIWQRLNNAKAQREKSLEGASSVELFNRTCDEAKVWMSEK 1150
            .|.:.....||.:..::...|.::::.||......:::.::::.|..|..:...|:|...|:.:|
Mouse   909 LAANNLVESGHPRSGEVKQYQDRLNKRWQAFQAVVSEQREAVDSALRVNNYCVDCEETSKWIMDK 973

  Fly  1151 MLQLD-TAVITPDLRTVQALQRRHQNLERELAPVEDKVNRVTYLGNSVKNAYPAEKDNVNARQQE 1214
            ...:: |..:..||..|.|:||:...|||::..:.|:|:.:......:..::|.:|:::..||.:
Mouse   974 TKVVESTKDLGQDLAGVIAIQRKLSGLERDVLAIRDRVSALERESQYLMESHPEQKEDIGQRQAD 1038

  Fly  1215 VQDMWQQVQQ--RGSDLRNRIESEVGQQVFNNSAKVLLAWIDSVKDQLNADESARDVETANNLLK 1277
            |:.:|:.:|.  :|.:|.....|::  |.|........||:...:..:.:::....:..|..||:
Mouse  1039 VEKLWKGLQDALQGQELSLGEASKL--QAFLQDLDDFKAWLSMAQKAVASEDMPESLPEAEQLLQ 1101

  Fly  1278 KHNDLGDDIRAHDTEFVEVIQLGKQLSDGK--PNMAETVAVIERLKAEQDAIHRGWAEKQKWLLQ 1340
            :|..:.::|.||..::..|...|:::.:|:  |:.......:|.|..:.||:.|.|..:...|.|
Mouse  1102 QHAAIKEEIDAHRDDYHRVKASGEKVIEGQTDPDYQLLGQRLEGLDTDWDALRRMWESRGNTLTQ 1166

  Fly  1341 CVDLQMFNREADKIDATTKSHEAFLEYNNLGASLDEVEAILKRHLDFEKSL-MAQDKILKGFSDN 1404
            |:..|.|.::|.:.:|...:.|..|.:.....||...||.:::..||..|: ..:||||... |:
Mouse  1167 CLGFQEFQKDAKQAEAILSNQEYTLAHLEPPDSLAAAEAGIRKFEDFLVSMENNRDKILSPV-DS 1230

  Fly  1405 ADKLISNDHYDSKYIGDRRNQVLGKRKAVKDRAFERKRLLQASKDFHKFAAEADDLKVWLQDKTR 1469
            .:||::..:..|..|.::...:..:.|...::|.|...||:.:.:...|.....:|.:|:.||..
Mouse  1231 GNKLVAEGNLYSNKIMEKVQLIEDRHKKNNEKAQEATVLLKDNLELQNFLQNCKELTLWINDKLL 1295

  Fly  1470 IAGDENYRDLSNLPRKLQKHQAFERELRANEGQLRNVTKDGQALVQAGNRVPEVES-RVADLNKR 1533
            .:.|.:|.:..||..|..|||||..||.:::|.|.|:..:|:.|:....:..:|.| |:..|:|.
Mouse  1296 TSPDVSYDEARNLHNKWMKHQAFMAELASHQGWLENIDAEGRQLMAEKPQFKDVVSERLEALHKL 1360

  Fly  1534 WKDLLTLSEDKGRKLEQAASQREHNRSLEDAKKKVDELDSALRSGDVGNDLRSCKDLINKQQILE 1598
            |::|.:.::.|..:|..|.|.....::..|..|.:..::..|||.|:|.||.:...::.|.:.:|
Mouse  1361 WEELQSTAKAKAEQLSAARSSDLRLQTHADLNKWIGAMEDQLRSDDLGKDLTTVNRMLAKLKRVE 1425

  Fly  1599 SEITIWDQKVAELVSTGDDMAHGGHFNAQNIEAGTKE--LQQRFKDLRDPTQRRRAKLEESLNYH 1661
            .::.:..:::.||.:....:         ..|||..:  :::||.||.:|..||:.:||.|....
Mouse  1426 EQVNLRKEELEELFADAPSL---------GAEAGDTDMSIEKRFLDLLEPLGRRKKQLELSKAKL 1481

  Fly  1662 KFVFELDSEFQWINEHLPAAKSNELGQNLHQAQSLHKKHKKLEAEIKGHQPMINKALVAGQSLIS 1726
            :...:|:.|..|:.|.||.|:|.:.|.||...|...||::.|:.||.||.|.:...|..||.|:.
Mouse  1482 QISRDLEDETLWVEERLPLAQSADYGTNLQTVQLFMKKNQTLQNEILGHAPRVEDVLRRGQELVK 1546

  Fly  1727 QQHPEREQVESLCQQLEQAWQDLERHCGERSRKLDMSLKAQQYLFDAGEIESWLGERNNVLRSTE 1791
            ....:.:.:|.....|:.:|..|......|.::|..:.:||||..||||.|:|:.|:...:.|.|
Mouse  1547 AAEIDCQDIEERLGHLQSSWDTLREAAAGRLQRLRDAHEAQQYYLDAGEAEAWISEQELYVFSDE 1611

  Fly  1792 YGRDRDSAAKLLTKHKTIELELDTYSGIVTEMGHSCAAMVAANHPDSKVLAAKQQLIEKMLKSLH 1856
            ..:|.:.|..:|.:|...:..::.|...:.::.....::::|.||:.:.:...|..::|....|.
Mouse  1612 PPKDEEGAIVMLKRHLRQQRTVEEYGRNIKQLAGRAQSLLSAGHPEGEQIIRLQGQVDKQYAGLK 1676

  Fly  1857 KLASQRQGRLMESLYKHEYFL--ESDEVEQWIREQEQAASSEDYGQDFEHLQLLQNKFDDLKHRV 1919
            .:|.:|:.|| |::| |.:.|  |:|::||||.|:|..|||::.||||:|:.:|::||.|.....
Mouse  1677 DMAEERRRRL-ENMY-HLFQLKREADDLEQWITEKEMVASSQEMGQDFDHVTMLRDKFRDFARET 1739

  Fly  1920 -EVGADRVDQCELLAKKLIDSESPYANEVEKRQEQLRTSWENLLQLLNQREQKLHAAGEIHRFHR 1983
             .:|.:|||....:.::|||:....|..:.:.::.|...|.:||:|::.|.|.|.|:.::||:..
Mouse  1740 GAIGQERVDNVNTIIERLIDAGHSEAATIAEWKDGLNDMWADLLELIDTRMQLLAASYDLHRYFY 1804

  Fly  1984 DVAEALFRIQDKNAALSQELGRDLNSALALLRKHEGFENDLVALEAQLQVLVEDSVRLQAKYP-S 2047
            ...|.|..|.:|:..|.:::|.|.::|.:..|.|..||.:|..|..|:|...:.:.|||..|. .
Mouse  1805 TGTEILGLIDEKHRELPEDVGLDASTAESFHRVHTAFERELHLLGVQVQQFQDVATRLQTAYAGE 1869

  Fly  2048 NASAIAQQQDKVVAAWNDLKERSTARGDRLAASSDLQTFLTDVRDIVSWSSNLRAALQAEEHVSD 2112
            .|.||..::.:|.|||..|.:....|..:|..::|...|.:.|||::||..::...::.:|...|
Mouse  1870 KADAIQSKEQEVSAAWQALLDACAGRRAQLVDTADKFRFFSMVRDLLSWMESIIRQIETQERPRD 1934

  Fly  2113 AAGATALKIQHDAIYGEIEAREDKFRYLNELSDSMVQTGHYAAADVEEKCAAMLDERQKLHAAWN 2177
            .:....|...|..|..||..|...|....||.:|::|..|.|:.::.||...::..||:::..|.
Mouse  1935 VSSVELLLKYHQGIKAEINTRAKNFSTCLELGESLLQRQHQASDEIREKLQQVISRRQEMNDKWE 1999

  Fly  2178 KKKIMLEQKIDLFCFLRDAKQIDNLSSSQQAALSSSDFGQTVEDVQNKIRKHDEFERLIQTQEEK 2242
            .:...|...:::..|.|||...:....:|:..|:|.|||.||:.|:..|::|:.||:...:..|:
Mouse  2000 ARSDRLHMLLEVCQFSRDASVAEAWLIAQEPYLASRDFGHTVDSVEKLIKRHEAFEKSTASWAER 2064

  Fly  2243 VSLLQE 2248
            .:.|::
Mouse  2065 FAALEK 2070

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
kstNP_001097492.2 CH_beta_spectrin_rpt1 61..176 CDD:409042 65/115 (57%)
CH_beta_spectrin_rpt2 196..302 CDD:409043 66/106 (62%)
SPEC 450..640 CDD:238103 60/195 (31%)
SPEC 658..832 CDD:238103 47/176 (27%)
SH3 885..935 CDD:214620 3/49 (6%)
SPEC 1030..1236 CDD:238103 44/212 (21%)
SPEC 1134..1341 CDD:238103 48/211 (23%)
SPEC 1343..1551 CDD:238103 58/209 (28%)
SPEC 1449..1658 CDD:238103 58/211 (27%)
SPEC 1555..1764 CDD:238103 56/210 (27%)
SPEC 1765..1975 CDD:238103 68/212 (32%)
SPEC 1873..2080 CDD:238103 71/210 (34%)
SPEC 1979..2185 CDD:238103 60/206 (29%)
SPEC 2188..2402 CDD:238103 19/61 (31%)
SPEC 2407..2618 CDD:238103
SPEC 2514..2725 CDD:238103
SPEC 2726..2934 CDD:238103
SPEC 2935..3145 CDD:238103
SPEC 3042..3251 CDD:238103
SPEC 3149..3357 CDD:238103
SPEC 3359..3567 CDD:238103
SPEC 3465..3680 CDD:238103
PH_beta_spectrin 3801..3904 CDD:269975
SptbNP_038703.3 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..30
Actin-binding 2..275 139/240 (58%)
CH_SPTBN2_rpt1 25..156 CDD:409166 65/115 (57%)
CH_SPTB_rpt2 170..281 CDD:409168 68/113 (60%)
Spectrin 302..411 CDD:395348 52/108 (48%)
Spectrin 1. /evidence=ECO:0000255 303..411 52/107 (49%)
Spectrin 422..526 CDD:395348 38/103 (37%)
Spectrin 3. /evidence=ECO:0000255 529..635 31/105 (30%)
SPEC 530..742 CDD:238103 63/214 (29%)
Spectrin 4. /evidence=ECO:0000255 638..741 31/105 (30%)
SPEC 641..848 CDD:238103 65/371 (18%)
Spectrin 5. /evidence=ECO:0000255 744..846 32/263 (12%)
SPEC 745..954 CDD:238103 49/370 (13%)
Spectrin 6. /evidence=ECO:0000255 853..950 16/96 (17%)
Spectrin 7. /evidence=ECO:0000255 958..1058 25/99 (25%)
SPEC 962..1168 CDD:238103 49/207 (24%)
Spectrin 8. /evidence=ECO:0000255 1062..1165 21/104 (20%)
SPEC 1170..1379 CDD:238103 58/209 (28%)
Spectrin 9. /evidence=ECO:0000255 1170..1258 22/88 (25%)
Spectrin 10. /evidence=ECO:0000255 1275..1376 30/100 (30%)
SPEC 1385..1475 CDD:197544 23/98 (23%)
Spectrin 11. /evidence=ECO:0000255 1389..1463 18/82 (22%)
Spectrin 12. /evidence=ECO:0000255 1481..1582 30/100 (30%)
SPEC 1485..1690 CDD:238103 59/205 (29%)
Spectrin 13. /evidence=ECO:0000255 1584..1688 28/104 (27%)
SPEC 1691..1901 CDD:238103 71/209 (34%)
SPEC 1798..2005 CDD:238103 59/206 (29%)
Spectrin 15. /evidence=ECO:0000255 1798..1899 31/100 (31%)
Spectrin 16. /evidence=ECO:0000255 1906..2006 26/99 (26%)
Spectrin 17. /evidence=ECO:0000255 2013..2073 19/58 (33%)
Spectrin 2013..>2070 CDD:395348 19/56 (34%)
PH_beta_spectrin 2182..2287 CDD:269975
Blue background indicates that the domain is not in the aligned region.

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