DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment kst and unc-70

DIOPT Version :10

Sequence 1:NP_001097492.2 Gene:kst / 38418 FlyBaseID:FBgn0004167 Length:4337 Species:Drosophila melanogaster
Sequence 2:NP_001256073.1 Gene:unc-70 / 179077 WormBaseID:WBGene00006803 Length:2326 Species:Caenorhabditis elegans


Alignment Length:2255 Identity:686/2255 - (30%)
Similarity:1155/2255 - (51%) Gaps:214/2255 - (9%)


- Green bases have known domain annotations that are detailed below.


  Fly    33 PGGYSALQTPT----PSNRNSANMTQRDGI-----IKFENERIKTLQEERLHIQKKTFTKWMNSF 88
            ||...||.:.:    ..||:..:....|.:     |...:.|.:.|::||..:||||||||:||.
 Worm    58 PGSAGALSSLSNGLADENRSPTSAEVSDSVCGQKSINSVDLRFRGLRDERELVQKKTFTKWVNSH 122

  Fly    89 LIKAKMEVEDLFTDLADGIKLLKLLEIISSEKLGKPNSGRMRVHKIENVNKSLAFLHTK-VRLES 152
            |::...:|:||:.|:.||..||:||.::|.|:|.||..|:||:|.:|||.|.|.||..: |.||:
 Worm   123 LVRVSCKVQDLYMDMRDGKMLLRLLAVLSGERLPKPTPGKMRIHCLENVEKGLQFLRNQHVHLEN 187

  Fly   153 IGAEDIVDGNPRLILGLIWTIILRFQIQEIEIDVDEENESSEKRSAKDALLLWCQRKTHGYPGVN 217
            :|:.||||||.||.||||||||||||||:|..   |:.::.|.||||:|||||||.||.|||.||
 Worm   188 LGSHDIVDGNSRLTLGLIWTIILRFQIQDITF---EDADNHETRSAKEALLLWCQMKTAGYPNVN 249

  Fly   218 ITDFTNSWRSGLGFNALIHSHRPDLFEYSTIVNSKNSNLDNLNHAFDTAANELGIPSLLDAEDID 282
            :.:|:.|||.||.||||||.|||||.:|..:  .|::.|.||..|||||.|:||:...|||||::
 Worm   250 VKNFSTSWRDGLAFNALIHKHRPDLVDYDNL--QKSNALYNLQSAFDTAENQLGLAKFLDAEDVN 312

  Fly   283 SARPDEKSILTYVASYYHTFARMKNEQKSGKRIANIVGQLMDADRKKMQYEGLTTNLLSWIRQKT 347
            ..:||||||:|||.:|||.|.::|.:...||||..::.:||:.|:...:||.|:::||.||..|.
 Worm   313 VDQPDEKSIITYVVTYYHYFNKLKQDNIQGKRIGKVINELMENDKMINRYETLSSDLLEWINAKI 377

  Fly   348 LELEQRDLPNSLEGIQRELLAFKEYRTIEKPPKYKERSEIEALYFTINTLLKALNQPPYNPQDGQ 412
            ..|.:|...|:|||:||:|..|.:|||.|||||:.|:.|:|.|.||:.:.::|.||.|:.|::|:
 Worm   378 QLLNERHFENNLEGVQRQLTEFNDYRTQEKPPKFDEKGELEVLLFTLQSAMRANNQRPFVPREGK 442

  Fly   413 LVNDIEKAWQILEYAEHHREVALRDELLRQEKLEQLNYKFEKKSVLREGYLKEMIQVLSDPRY-- 475
            |:.||.:|||.||.|||.||:.|::||:||||||||..:|.:|:.:||.:|.|..:::|...:  
 Worm   443 LIADINRAWQSLEKAEHERELVLKEELIRQEKLEQLAARFNRKAEMRETWLTENQRLVSQDNFGN 507

  Fly   476 -LRQVDATLKKHEAISADILARVERFNDLTAMAEELDRENYHGKERVRRREQEVMAKWRQLLELL 539
             |..|:|..||||||..||.|..||...:.|:|.||:.||||.:.::..|::.|:..|..|.:||
 Worm   508 DLSSVEAATKKHEAIETDIFAYEERVQAVVAVAGELEAENYHDQAKINERKENVLQLWNYLFQLL 572

  Fly   540 ENQRLNLSQMSNLMNLLREIASTTEAVRELQQQFASEDVGPHLLGVEELLQAHSLQELQVNTYGE 604
            ..:|:.|.....:..:..::..|.:.:.:::.:..|||:|.||:.||:|||.|:|.|..:|..||
 Worm   573 LARRVRLELSMAIQKIFHDMLLTLDLMDDIKSRLLSEDLGAHLMDVEDLLQKHALLESDINIIGE 637

  Fly   605 TLKRFNRQALPYKSSEHKDAA--------LLAQRLADLEEAYSELLRRSAARRARLEEARNFHHF 661
            .:.....||..:::.:..|.:        .:.:|...|::.|.|||..:|.|:.|||:.:....|
 Worm   638 RVNNSIAQAQRFRNPDGPDGSGYKPVEPGTIDERSDVLQKRYKELLDLAAERKRRLEDNKRLCQF 702

  Fly   662 MEDYDNEESWLVDKQRICKTGITAKDLRAVLSLQQKHKALEDEIKSRKPKSGQMSTAGKRLIGEQ 726
            ..|....|..:.:::::..:..|.:|:..|..|..|||..|:.::..:....::..:||.|..|.
 Worm   703 WWDVAELEHGIKEQEQVLSSTDTGRDIVTVSHLLAKHKNAENNLRDLEKYLDRLDVSGKELQDES 767

  Fly   727 HPRSSEIQSRIDSLAEHWQALEALVELRRRQLEDAAEAYQFYTDANEAESWLNEKIALVNSRDYG 791
            .|.|..|..|:..:.::...|:.|...|:.:|....|.|||:|||::.:.:|.:.:.:::|.|.|
 Worm   768 IPGSDNIPPRLAEIRDYINKLKELSASRKERLAGGVEYYQFFTDADDVDRYLYDTLRVMSSEDVG 832

  Fly   792 NDEPSAQALLQRHRDLQGELNAYSGDILNLNQQADKLIKAGICTLELSAAEPELPEVEQEEWVNE 856
            .||.:.|.||::|.|:..||           |..|:.||.      |.|....||:         
 Worm   833 KDEGTVQLLLKKHDDVHDEL-----------QNFDQHIKV------LHAKAESLPQ--------- 871

  Fly   857 TRLVPKEVWEDEWVEKLEHKKVTETKMLPHVKSLFPFEGQGMKMDKGEVMLLKSKTNDDWWCVRK 921
                          |..||                                              
 Worm   872 --------------EAREH---------------------------------------------- 876

  Fly   922 DNGVEGFVPANYVREVEPRPVACIVPKAEKVKSLQKVKKTILVRQVVPVKRIKPVSVAPKPLVQR 986
                                                                        |.:::
 Worm   877 ------------------------------------------------------------PDIRQ 881

  Fly   987 RTSTQSINENADSVEKRQQRINQTYDELQEMAQKRHALLEDSIHLFGFYRECDDFEKWMKEKER- 1050
            |..| ::.:.|               ||:.::|.|...|.|::.|:..|.:.|..|.|:.||.: 
 Worm   882 RLDT-TLKQKA---------------ELENLSQLRKQRLIDALSLYKLYSDADSVESWIDEKGKL 930

  Fly  1051 ---MIKSDEGEGVDNAKRKFEKFITDLSAASKRVEEIDGAVDTFRRQGHSQLDKIIARQRQIHQI 1112
               ::...:.|.|:..|.:|:....|:.....:|..::..........|...|.|:.||.:::..
 Worm   931 LATLVPGRDIEEVEIMKHRFDTLEQDMKNQEAKVTNVNDLARQLLNVEHPNSDDILHRQNKLNAR 995

  Fly  1113 WQRLNNAKAQREKSLEGASSVELFNRTCDEAKVWMSEKMLQL-DTAVITPDLRTVQALQRRHQNL 1176
            |.:|.:...|:...||.|..:|.|...|.|...|:.:|...| |:..:|.||..|..||||...:
 Worm   996 WAQLRDMVDQKRNELERAHRLETFRIDCQETVTWIEDKTRVLEDSDALTNDLSGVMKLQRRLSMM 1060

  Fly  1177 ERELAPVEDKVNRVTYLGNSVKNAYPAEKDNVNARQQEVQDMWQQVQQRGSDLRNRIESEVGQQV 1241
            ||:|..::.|::.:....:.::...|.|...:....:.:..:|..:.::..:...:::.....|.
 Worm  1061 ERDLGAIQAKLDSLHKEADDIERERPQEAQAIREDIKRIHQVWDILNKKVREHEAKLDEAGDLQR 1125

  Fly  1242 FNNSAKVLLAWIDSVKDQLNADESARDVETANNLLKKHNDLGDDIRAHDTEFVEVIQLGKQLSDG 1306
            |........||:.:.:.|:.::|..:.:..|..||.:|..:.::|..:..::.::..:|.:::..
 Worm  1126 FLRDLDHFQAWLTATQRQVASEEEPQSLAEAEQLLNQHAAIREEIDGYAEDYKKMRAMGDRVTQD 1190

  Fly  1307 KPNMAETVAVIERLKAEQDA---IHRGWAEKQKWLLQCVDLQMFNREADKIDATTKSHEAFLEYN 1368
            :.: .:.:.:.:||...|:.   :.|.|..:|..|.|.::||||.|:|.:.:......|.:|..:
 Worm  1191 QTD-PQYMFLRQRLAGLQEGWEELQRMWDNRQHLLSQGLNLQMFLRDAKQAEVMLSQQENYLAKD 1254

  Fly  1369 NLGASLDEVEAILKRHLDFEKSLMAQDKILKGFSDNADKLISNDHYDSKYIGDRRNQVLGKRKAV 1433
            ::..||::.|..||||.||..::.|.|:.::......|:|..:.||.:..|..:...:..:|.|.
 Worm  1255 DIPQSLEQAENQLKRHQDFITTMDANDEKIRAVGMFGDQLCQDGHYAADKIHKKARNIDERRGAN 1319

  Fly  1434 KDRAFERKRLLQASKDFHKFAAEADDLKVWLQDKTRIAGDENYRDLSNLPRKLQKHQAFERELRA 1498
            :::|.|..:.|:.:....:|.::.|:|:.|:::|...|.||.|||...:..|..:||||:.||.|
 Worm  1320 REKAQEVLKKLKDALSLQQFLSDCDELREWIEEKMIRAQDETYRDAKTITSKFVRHQAFQSELAA 1384

  Fly  1499 NEGQLRNVTKDGQALVQAGNRVPE----VESRVADLNKRWKDLLTLSEDKGRKLEQAASQREHNR 1559
            |:.:|..:.   .|.:..|:..||    ::.::.:|..:|.:|...:|:||:||..|..|:.:.:
 Worm  1385 NKERLDQLK---HAAINLGDDKPEYHGTIDPQIEELATQWDELEKTTEEKGQKLFDANRQQLYVQ 1446

  Fly  1560 SLEDAKKKVDELDSALRSGDVGNDLRSCKDLINKQQILESEITIWDQKVAELVSTGDDMAHGGHF 1624
            |:.|.|:...:|::.:...|...||.:....:.||.::|:|:....|.:.:|:.....:......
 Worm  1447 SIADMKEWATQLENEMTREDQPGDLTTVNVAMQKQHLIETEMIKKAQHIDQLMEMEPQLEELHPD 1511

  Fly  1625 NAQNIEAGTKELQQRFKDLRDPTQRRRAKLEESLNYHKFVFELDSEFQWINEHLPAAKSNELGQN 1689
            ..:||:|....:|::.:.|:.|...||..||......:|..::|.|..||:|.|..||:..||::
 Worm  1512 ELENIKAHRLAVQEQLQRLQAPLDDRRKALERKKAAFQFGRDVDDEKLWISERLVLAKAQNLGES 1576

  Fly  1690 LHQAQSLHKKHKKLEAEIKGHQPMINKALVAGQSLISQQHPEREQVESLCQQLEQAWQDLERHCG 1754
            |.....|.|..:.|..||..|:|.||:....||.||.:.|......|...|:|..|||:|:....
 Worm  1577 LPDCHRLQKNLQLLSNEIDNHEPWINQICNNGQELIDEGHANGPAFEKKIQELRSAWQELKEAVK 1641

  Fly  1755 ERSRKLDMSLKAQQYLFDAGEIESWLGERNNVLRSTEYGRDRDSAAKLLTKHKTIELELDTYSGI 1819
            :|...|..|.||.|:|:|.||.|:|:.|:...:...|.|:|..|....:.||:.::.::|.::..
 Worm  1642 DRKGDLGESEKAHQFLYDCGEAEAWMSEQELYMMQDERGKDEFSTKNQIKKHERLQSDIDKFADT 1706

  Fly  1820 VTEMGHSCAAMVAANHPDSKVLAAKQQLIEKMLKSLHKLASQRQGRLMESLYKHEYFLESDEVEQ 1884
            :..:.......|....|.::.:..:|..|||:...|..|:.:|:.||.|:|..:....|.|::.|
 Worm  1707 IRALATKAHKFVEEKSPLTEQIQVRQAQIEKLYAGLQDLSKERRKRLEETLELYALHREIDDLLQ 1771

  Fly  1885 WIREQEQAASSEDYGQDFEHLQLLQNKFDDLKHRVE-VGADRV----DQCELLAKKLIDSESPYA 1944
            ||.::|..|.|::.|||:||:|:||.:|.......| :|::||    |.|:    .||......|
 Worm  1772 WIADKEVVAGSQENGQDYEHVQMLQERFQQFARDTENIGSERVANANDGCD----TLIGHGHTDA 1832

  Fly  1945 NEVEKRQEQLRTSWENLLQLLNQREQKLHAAGEIHRFHRDVAEALFRIQDKNAALSQELGRDLNS 2009
            ..:...::.|..:|||||:|::.|.|.|.|:..:|:|:.|..:.|.||.:|..|:..:||||.:|
 Worm  1833 PTIALWKDSLNEAWENLLELMDTRAQILEASRLLHKFYHDCRDCLSRIMEKTHAMPDDLGRDSSS 1897

  Fly  2010 ALALLRKHEGFENDLVALEAQLQVLVEDSVRLQAKYPSN-ASAIAQQQDKVVAAWNDLKERSTAR 2073
            ..||.|||:.:..|:.|:..|:..:..|:..|:..|..: |..|..::.:||.||..|:....||
 Worm  1898 VGALSRKHQNYLKDIAAIGEQVAQIERDAAELRDGYAGDKALDIGSRESEVVKAWRHLRGLCDAR 1962

  Fly  2074 GDRLAASSDLQTFLTDVRDIVSWSSNLRAALQAEEHVSDAAGATALKIQHDAIYGEIEAREDKFR 2138
            ..||..:|||..|:..|||::.|...::..:.::|...|.:|...|...|.::..||:|||:.|.
 Worm  1963 TSRLMDTSDLFKFMNMVRDLLLWMDEVKREMNSQERPKDVSGVELLMNNHQSLKAEIDAREENFN 2027

  Fly  2139 YLNELSDSMVQTGHYAAADVEEKCAAMLDERQKLHAAWNKKKIMLEQKIDLFCFLRDAKQIDNLS 2203
            ....|...::...|||::::|:|...:..||.::...|..:...|:..::::.|.|||...::..
 Worm  2028 ACISLGRDLLNRKHYASSEIEKKLIKLTTERAEMMRRWEDRWEYLQLILEVYQFARDAAVAESWL 2092

  Fly  2204 SSQQAALSSSDFGQTVEDVQNKIRKHDEFERLIQTQEEKVSLLQE 2248
            .:|:..|.|.::|:.:|:....|:||:.||:....|||:...|::
 Worm  2093 FAQEPYLISKEYGRNLEETIKLIKKHEAFEKSAFAQEERFLALEK 2137

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
kstNP_001097492.2 CH_beta_spectrin_rpt1 61..176 CDD:409042 61/115 (53%)
CH_beta_spectrin_rpt2 196..302 CDD:409043 65/105 (62%)
SPEC 450..640 CDD:238103 61/200 (31%)
SPEC 658..832 CDD:238103 47/173 (27%)
SH3 885..935 CDD:214620 0/49 (0%)
SPEC 1030..1236 CDD:238103 47/210 (22%)
SPEC 1134..1341 CDD:238103 42/210 (20%)
SPEC 1343..1551 CDD:238103 62/211 (29%)
SPEC 1449..1658 CDD:238103 58/212 (27%)
SPEC 1555..1764 CDD:238103 58/208 (28%)
SPEC 1765..1975 CDD:238103 66/214 (31%)
SPEC 1873..2080 CDD:238103 72/212 (34%)
SPEC 1979..2185 CDD:238103 64/206 (31%)
SPEC 2188..2402 CDD:238103 18/61 (30%)
SPEC 2407..2618 CDD:238103
SPEC 2514..2725 CDD:238103
SPEC 2726..2934 CDD:238103
SPEC 2935..3145 CDD:238103
SPEC 3042..3251 CDD:238103
SPEC 3149..3357 CDD:238103
SPEC 3359..3567 CDD:238103
SPEC 3465..3680 CDD:238103
PH_beta_spectrin 3801..3904 CDD:269975
unc-70NP_001256073.1 CH_SPTB-like_rpt1 99..211 CDD:409095 61/111 (55%)
CH_SPTB_like_rpt2 228..332 CDD:409097 65/105 (62%)
SPEC 368..580 CDD:238103 95/211 (45%)
SPEC 481..695 CDD:238103 68/213 (32%)
SPEC 698..908 CDD:238103 64/371 (17%)
SPEC 804..1014 CDD:238103 64/371 (17%)
SPEC 910..1120 CDD:238103 47/209 (22%)
SPEC 1122..1334 CDD:238103 49/212 (23%)
SPEC 1230..1439 CDD:238103 62/211 (29%)
SPEC 1440..1650 CDD:238103 59/209 (28%)
SPEC 1652..1864 CDD:238103 67/215 (31%)
SPEC 1865..2073 CDD:238103 63/207 (30%)
SPEC 2079..>2157 CDD:197544 18/59 (31%)
PH_beta_spectrin 2189..2290 CDD:269975
Blue background indicates that the domain is not in the aligned region.

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