DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment PHGPx and GPX4

DIOPT Version :9

Sequence 1:	NP_728869.1	Gene:	PHGPx / 38413	FlyBaseID:	FBgn0035438	Length:	238	Species:	Drosophila melanogaster
Sequence 2:	NP_001034937.1	Gene:	GPX4 / 2879	HGNCID:	4556	Length:	234	Species:	Homo sapiens

Alignment Length:	237	Identity:	88/237 - (37%)
Similarity:	130/237 - (54%)	Gaps:	30/237 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 RQALRCYSM--------RRTPGPVLELSRGQRQCLRLCTIMLPVSCAATPMNAISSAAQHSTAAA 67
            |:..||.|.        ||...|.....|.:|:..:.|...|.......|.:....|::
Human    11 RRRQRCQSRGRRRPRAPRRRKAPACRRRRARRRRKKPCPRSLRPEIHECPKSQDPCASR------ 69

  Fly    68 IDMSANGDYKNAASIYEFTVKDTHGNDVSLEKYKGKVVLVVNIASKCGLTKNNYEKLTDLKEKYG 132
                  .|::.|.|::||:.||..|:.|:|:||:|.|.:|.|:||:.|.|:.||.:|.||..:|.
Human    70 ------DDWRCARSMHEFSAKDIDGHMVNLDKYRGFVCIVTNVASQUGKTEVNYTQLVDLHARYA 128

  Fly   133 ERGLVILNFPCNQFGSQMPEADGEAMVCHLRDSKADIG---EVFAKVDVNGDNAAPLYKYLK--A 192
            |.||.||.|||||||.|.|.::.|     :::..|...   ::|:|:.||||:|.||:|::|  .
Human   129 ECGLRILAFPCNQFGKQEPGSNEE-----IKEFAAGYNVKFDMFSKICVNGDDAHPLWKWMKIQP 188

  Fly   193 KQTGTLGSGIKWNFTKFLVNKEGVPINRYAPTTDPMDIAKDI 234
            |..|.||:.|||||||||::|.|..:.||.|..:|:.|.||:
Human   189 KGKGILGNAIKWNFTKFLIDKNGCVVKRYGPMEEPLVIEKDL 230

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PHGPx	NP_728869.1	GSH_Peroxidase	81..234	CDD:238207	72/157 (46%)
GPX4	NP_001034937.1	GSH_Peroxidase	77..230	CDD:238207	72/157 (46%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	96	1.000	Domainoid score	I7330
eggNOG	1	0.900	-	-		E1_COG0386
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	147	1.000	Inparanoid score	I4420
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG48732
OrthoDB	1	1.010	-	-		D1483113at2759
OrthoFinder	1	1.000	-	-		FOG0000791
OrthoInspector	1	1.000	-	-		otm41216
orthoMCL	1	0.900	-	-		OOG6_100297
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R16331
SonicParanoid	1	1.000	-	-		X276
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	13	12.810