DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment PHGPx and GPX6

DIOPT Version :9

Sequence 1:NP_728869.1 Gene:PHGPx / 38413 FlyBaseID:FBgn0035438 Length:238 Species:Drosophila melanogaster
Sequence 2:NP_874360.1 Gene:GPX6 / 257202 HGNCID:4558 Length:221 Species:Homo sapiens


Alignment Length:184 Identity:58/184 - (31%)
Similarity:88/184 - (47%) Gaps:33/184 - (17%)


- Green bases have known domain annotations that are detailed below.


  Fly    81 SIYEFTVKDTHGND-VSLEKYKGKVVLVVNIASKCGLTKNNYEKLTDLKEKYGERGLVILNFPCN 144
            :|||:.....:|.: :..:::.||.||.||:|:..||.. .|.:|..|:|:....|:::|.||||
Human    39 TIYEYGALTLNGEEYIQFKQFAGKHVLFVNVAAYUGLAA-QYPELNALQEELKNFGVIVLAFPCN 102

  Fly   145 QFGSQMPEADGEAM-----VCHLRDSKADIG-----EVFAKVDVNGDNAAPLYKYLKAKQTGT-- 197
            |||.|.|..:.|.:     ||      ...|     ::|.|.||||:....::.:||.....|  
Human   103 QFGKQEPGTNSEILLGLKYVC------PGSGFVPSFQLFEKGDVNGEKEQKVFTFLKNSCPPTSD 161

  Fly   198 -LGSG------------IKWNFTKFLVNKEGVPINRYAPTTDPMDIAKDIEKLL 238
             |||.            |:|||.||||..:|||:..:........:..||.:.|
Human   162 LLGSSSQLFWEPMKVHDIRWNFEKFLVGPDGVPVMHWFHQAPVSTVKSDILEYL 215

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
PHGPxNP_728869.1 GSH_Peroxidase 81..234 CDD:238207 55/178 (31%)
GPX6NP_874360.1 GSH_Peroxidase 39..211 CDD:238207 55/178 (31%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG0386
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D1483113at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
32.820

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