DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Strip and FAR11

DIOPT Version :9

Sequence 1:	NP_647806.2	Gene:	Strip / 38412	FlyBaseID:	FBgn0035437	Length:	927	Species:	Drosophila melanogaster
Sequence 2:	NP_014272.3	Gene:	FAR11 / 855596	SGDID:	S000005071	Length:	953	Species:	Saccharomyces cerevisiae

Alignment Length:	956	Identity:	187/956 - (19%)
Similarity:	331/956 - (34%)	Gaps:	322/956 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly    56 DTDTHDA--------DANCDGPDLDFVYAD-VDGYQ------------NEIAEL-YSYTEFSEFQ 98
            |.:|.:|        :|..:..|..|...| :||:.            ||..|: |:.....|||
Yeast   132 DNNTDNAVEFQDDAEEAEEENEDESFANVDELDGFDLNKVSDGKHVPINEKGEVDYNMPVDKEFQ 196

  Fly    99 MNVKAFEDQMELYDLPP-------NWQ------KQDSAS--------------QRGIVMKLVD-Q 135
            .::......:|.....|       :|:      .:|..|              |.....|:.. |
Yeast   197 KSLDQCAASLEERSSAPYALQRAVDWELKMFYSLEDELSEWFCSSDYMHFGQTQTLFKQKITQPQ 261

  Fly   136 LEVSDRSFRMQAARCIL---------------YLAQGCWAEVQSDEEQHQITRDN--VLVLYQLG 183
            |...|.::......|::               |::.||:|...|..|..:|.|.|  :||.:...
Yeast   262 LFFDDENYAASVVECLIEDIPNSLASNLLALSYISMGCFAFTNSKSEHTKIIRRNNLMLVPHIQE 326

  Fly   184 VFASFIDLLNMEIESACSPDIVAVKITNVTLVDSTDIRVILSVLYIITETIRDEKEKGSEDYREL 248
            :..:|     .:|..:|..|...:|...:.|..|:      ::||.|.....:.:.:..|....:
Yeast   327 IVHAF-----KKIAISCRDDNRNLKKQTILLFHSS------TILYFICSICIEGRGENPEAVNVV 380

  Fly   249 ADSFVQEINSPLPDGELLAVKLLGMITRFCS----GAAPQFPMKKVVLLLWKVSLLGLGGMDVLK 309
            .|:|.:             ..||..:|::..    .:.....::.::.||:|:.:|..|...|.|
Yeast   381 IDAFEK-------------TDLLEFLTKYIENWRWNSRLAMRIRNMISLLFKLIVLQFGDSSVYK 432

  Fly   310 NLKNE-YRLKVGLEPITEDTLEVTKCMRASSPPATATDILENQYPKRNFKRSLMKQRFLDEPEQI 373
            ..|:. |.|. ||                             .||.::             ||::
Yeast   433 QTKSSIYNLH-GL-----------------------------TYPSKH-------------PEKL 454

  Fly   374 DMEMGGNEGQNNANNGSGNGGNGEEELSQYYRPYDDPSSSASTTSTANPNNQPSLTQPPAAVPPV 438
            .:.                        ..:|:.:.:..:|          ..|....|.:.:|
Yeast   455 SIS------------------------PLHYQAFREDITS----------RFPDYNMPSSGLP-- 483

  Fly   439 QITARLPWTPKVRQKDID------QFLDISRNKF---IGYSLIGDHESLA-------GLPQPIHE 487
                          ||:|      |||:|.|.|.   :..:||...:.:|       ..||.:|.
Yeast   484 --------------KDVDKSESLSQFLEIPRPKSKNPLNMALIVPEKHIATPAPSPPSSPQLMHL 534

  Fly   488 G-----FKTLQRHM-----YMS---------LAD-----VQIKKEEDIARNPISTHED------- 521
            |     .|:.|.:|     |.|         |.|     ::.|.:.||. .|.||.|.
Yeast   535 GEGPRPRKSFQTNMAYPCLYPSDNEGSEDDTLEDRIDLNIERKPDNDIV-IPFSTEEAARILSES 598

  Fly   522 -EIKLTPAEVLYQ------------AILPNLPQYMIAL-------------LKVLLAASPTSKSK 560
             ||||:..::.|:            ..|.|.|....||             :.::.......||.
Yeast   599 LEIKLSTKQLWYERDLFMITERGWKQQLENEPYDYAALNHDANSSKEEKSAICIMQRIDKYYKSC 663

  Fly   561 TESINIMADVLPRKMPLTATQS-------------TKLT--VDIGRHKEIIVKAVSAIILLYLKH 610
            ..|.|.:..||.:.|..:.|.:             ..||  ::|.|.||:.:|:.:.|:...||.
Yeast   664 LSSFNSLVFVLLQTMESSLTNNFHRKSEVSDKNLLNMLTPQLEIVRAKELSLKSAAGILHALLKW 728

  Fly   611 FKINHVYQFEFMSQHLV-------FANCIPLVLKFFNQTITE-----YVNTKNSIPLLDFPSCVI 663
            ||::|:.:||    ||.       :.|....:|..:::...|     ||.|.||.    :..|.:
Yeast   729 FKLSHILKFE----HLAVVIHDSRYINTCASILSKYSEVYPERVFNKYVQTPNSF----WKECSL 785

  Fly   664 GEQPDLSGDSFVYGGEMSDK---SYSWRNVFSCINLLRILNKLIKWKHSRVMMLVVFKSAP---- 721
            ..:......|....||:..:   |:::        |||||.|:...|..|:      |..|
Yeast   786 SNESYRESYSVDDSGEVDTEIMPSFAY--------LLRILRKVTGNKTQRL------KELPLSIG 836

  Fly   722 -ILKKTLKVRHAMMQLYVLKLLKMQTKYLGRQWRKSNMKTMSAIYAKVRHRLNDDWAFGNDLESR 785
             :.|:..::.:..|...:||:.:..|.:..::|:..:|:.:|.:|...:..|.|:|..|.|:...
Yeast   837 ILFKRYYRLFNLDMYHPILKITRELTPFKNKRWKSEHMELISGVYLYEKLELTDNWVTGKDISGE 901

  Fly   786 PWDFQAEECTLRACVDRFNLRRYPEATQKC--GNNGTAAQNAENAQ 829
            ..|...:|..|||.:..:|.:.|..:.:..  |:..:::|:..|.:
Yeast   902 LSDACGQEIALRALLQFYNFQHYEISMEDLGYGHRNSSSQDLLNKE 947

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Strip	NP_647806.2	N1221	69..344	CDD:285201	62/338 (18%)
Strip	NP_647806.2	DUF3402	482..826	CDD:288715	99/437 (23%)
FAR11	NP_014272.3	N1221	219..485	CDD:400327	57/382 (15%)
FAR11	NP_014272.3	DUF3402	585..928	CDD:403177	83/364 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157346279
Domainoid	1	1.000	52	1.000	Domainoid score	I2865
eggNOG	1	0.900	-	-		E1_KOG3680
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0002394
OrthoInspector	1	1.000	-	-		oto99262
orthoMCL	1	0.900	-	-		OOG6_103643
Panther	1	1.100	-	-	LDO	PTHR13239
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2109
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	9	8.860