DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Strip and strip1

DIOPT Version :9

Sequence 1:	NP_647806.2	Gene:	Strip / 38412	FlyBaseID:	FBgn0035437	Length:	927	Species:	Drosophila melanogaster
Sequence 2:	NP_001027483.1	Gene:	strip1 / 613075	XenbaseID:	XB-GENE-5768658	Length:	819	Species:	Xenopus tropicalis

Alignment Length:	882	Identity:	421/882 - (47%)
Similarity:	566/882 - (64%)	Gaps:	111/882 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    57 TDTHDADANCDGPDLDFVYADVDGYQNEIAELYSYTEFSEFQMNVKAFEDQMELYDLPPNWQKQD 121
            |...|::...:.|||:|:|||.|.:..|::|||||||..||.:|.|.||:...|:.....|.:.|
Frog    36 TQRKDSEGYSESPDLEFIYADSDKWAAELSELYSYTEGPEFHLNRKCFEEDFHLHVPDKKWTELD 100

  Fly   122 SASQRGIVMKLVDQLEVSDRSFRMQAARCILYLAQGCWAEVQSDEEQHQITRDNVLVLYQLGVFA 186
            .:.||...|:|:|.|||:.|..|::.||.|||:|||.:.:..|:.|.....|.|:.:|.:.|.|.
Frog   101 VSQQRAHTMRLLDALEVTAREKRLKVARAILYVAQGTFGDCSSEAEVQIWLRHNIFLLLEAGAFT 165

  Fly   187 SFIDLLNMEIE--SACSPDIVAVKITNVTLVDSTDIRVILSVLYIITETIRDEKEKGSEDYRELA 249
            :.::|||||:|  :|||.   ||:...::|.||||:||:|:::|::.:|:|:|.|..|.:::.:.
Frog   166 ALVELLNMEVENSAACSN---AVRKPAISLADSTDLRVLLNIMYLMVDTLREEAEGDSPEWKAMR 227

  Fly   250 DSFVQEINSPLPDGELLAVKLLGMITRFCSGAAPQFPMKKVVLLLWKVSLLGLGGMDVLKNLKNE 314
            .:|..|:.||..:.|..||.|.||:|:||||.||.||||||:|||||..|..|||.:.|..:|.:
Frog   228 QTFRTELGSPFYNNEPFAVMLFGMVTKFCSGHAPHFPMKKVLLLLWKTVLCTLGGFEELLEMKAQ 292

  Fly   315 YRLKVGLEPITEDTLEVTKCMRASSPPATATDILENQYPK-RNFKRSLMKQRFLD-----EPEQI 373
            .|..:||.|:.||:::|.:.|||:||||:|:|::|.|..: |...::|:||..||     :|.:.
Frog   293 KREILGLPPLPEDSIKVIRNMRAASPPASASDLIEQQQRRGRREHKALIKQDNLDAFNERDPYKA 357

  Fly   374 DMEMGGNEGQNNANNGSGNGGNGEEELSQYYRPYDDPSSSASTTSTANPNNQPSLTQPPA---AV 435
            | :...:|.:|:.:|...|            .|:........         .||:|.|||   |.
Frog   358 D-DSRDDEEENDEDNSLEN------------EPFSIEREEVM---------PPSVTHPPAERLAF 400

  Fly   436 PPVQITARLPWTPKVRQKDIDQFLDISRNKFIGYSLIGDHESLAGLPQPIHEGFKTLQRHMYMSL 500
            |     ..|||.||||:|||:.||:.||:|||||:|..|..::.|||:||||..:||:.|.|.|:
Frog   401 P-----KGLPWAPKVREKDIEMFLESSRSKFIGYTLGSDTNTVVGLPRPIHESIRTLKLHKYTSV 460

  Fly   501 ADVQIKKEEDIARNPISTHEDEIKLTPAEVLYQAILPNLPQYMIALLKVLLAASPTSKSKTESIN 565
            |:|||::||:..|.|:|..|:|::..|.|:|||.:||:||||||||||:||||:||||:||:|||
Frog   461 AEVQIRQEEEFLRCPLSGGEEEVEQVPTEILYQGLLPSLPQYMIALLKILLAAAPTSKAKTDSIN 525

  Fly   566 IMADVLPRKMPLTATQSTKLTVDIGRHKEIIVKAVSAIILLYLKHFKINHVYQFEFMSQHLVFAN 630
            |:|||||.:||.|..||.||.||:.|||||||||:||::||.|||||:||:||.|:|:|||||||
Frog   526 ILADVLPEEMPTTVLQSMKLGVDVNRHKEIIVKAISAVLLLLLKHFKLNHIYQMEYMAQHLVFAN 590

  Fly   631 CIPLVLKFFNQTITEYVNTKNSIPLLDFPSCVIGEQPDLSGDSFVYGGEMSDKSYSWRNVFSCIN 695
            ||||:||||||.|..|:..||||.:||:|..|:.|.|:|:.:|...|   .:..:.|||:|||||
Frog   591 CIPLILKFFNQNIMSYITAKNSISVLDYPYSVVHELPELTAESLEAG---DNNRFCWRNLFSCIN 652

  Fly   696 LLRILNKLIKWKHSRVMMLVVFKSAPILKKTLKVRHAMMQLYVLKLLKMQTKYLGRQWRKSNMKT 760
            ||||||||.||||||.|||||||||||||:.|||:.||||||||||||:||||||||||||||||
Frog   653 LLRILNKLTKWKHSRTMMLVVFKSAPILKRALKVKQAMMQLYVLKLLKVQTKYLGRQWRKSNMKT 717

  Fly   761 MSAIYAKVRHRLNDDWAFGNDLESRPWDFQAEECTLRACVDRFNLRRYPEATQKCGNNGTAAQNA 825
            |||||.|||||||||||:||||::||||||||||.|||.::|||.||| :.|.|
Frog   718 MSAIYQKVRHRLNDDWAYGNDLDARPWDFQAEECALRANIERFNSRRY-DRTHK----------- 770

  Fly   826 ENAQQSNMMAGNNGCGNNGDANGYGNNGGGGNGGHNQQQQLNDYGVEGGFPSDEILTHSDFAFFG 890
                             |.|.                            .|.|..|.    :..|
Frog   771 -----------------NPDF----------------------------LPVDNCLQ----SVLG 786

  Fly   891 HSGWWDRKVELTDYFKANYAVWLEEEVYNSQTDWDAL 927
                  ::|||.:.|:.||.:|||.||::....|:.|
Frog   787 ------QRVELPEDFQMNYDLWLEREVFSKPISWEEL 817

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Strip	NP_647806.2	N1221	69..344	CDD:285201	123/276 (45%)
Strip	NP_647806.2	DUF3402	482..826	CDD:288715	229/343 (67%)
strip1	NP_001027483.1	N1221	48..318	CDD:369597	119/272 (44%)
strip1	NP_001027483.1	DUF3402	442..765	CDD:371779	225/325 (69%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	244	1.000	Domainoid score	I2159
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H35064
Inparanoid	1	1.050	811	1.000	Inparanoid score	I474
OMA	1	1.010	-	-		QHG46345
OrthoDB	1	1.010	-	-		D1095402at2759
OrthoFinder	1	1.000	-	-		FOG0002394
OrthoInspector	1	1.000	-	-		otm47969
Panther	1	1.100	-	-	O	PTHR13239
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2109
SonicParanoid	1	1.000	-	-		X2094
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	13	13.110