DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Strip and strip1

DIOPT Version :9

Sequence 1:	NP_647806.2	Gene:	Strip / 38412	FlyBaseID:	FBgn0035437	Length:	927	Species:	Drosophila melanogaster
Sequence 2:	XP_009294388.1	Gene:	strip1 / 568805	ZFINID:	ZDB-GENE-040426-2927	Length:	814	Species:	Danio rerio

Alignment Length:	879	Identity:	423/879 - (48%)
Similarity:	564/879 - (64%)	Gaps:	111/879 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    61 DADANCDGPDLDFVYADVDGYQNEIAELYSYTEFSEFQMNVKAFEDQMELYDLPPNWQKQDSASQ 125
            |::...:.|||:|.|:|.|.:..|::|||||||..||.:|.|.||:....:.....|.:.||..:
Zfish    33 DSEGLSEAPDLEFEYSDADKWTAELSELYSYTEGPEFLLNRKCFEEDFHTHLPDQKWTELDSVQR 97

  Fly   126 RGIVMKLVDQLEVSDRSFRMQAARCILYLAQGCWAEVQSDEEQHQITRDNVLVLYQLGVFASFID 190
            |...|:|:|.|||..|..|::.||.|||:|||.:.|..|:.|.....|.||.:|..:|.|.:.::
Zfish    98 RAHAMRLLDGLEVIGRERRLKVARAILYMAQGTFGECSSELEVQHWMRYNVFLLLDVGAFTALVE 162

  Fly   191 LLNMEIE--SACSPDIVAVKITNVTLVDSTDIRVILSVLYIITETIRDEKEKGSEDYRELADSFV 253
            ||||||:  :|||.   ||:...::|.||||:||:|:::|::.|||:.|:...|.::|.:.::|.
Zfish   163 LLNMEIDNSAACSS---AVRKPAISLADSTDLRVLLNIMYLMVETIQREEPTDSPEWRTIRETFK 224

  Fly   254 QEINSPLPDGELLAVKLLGMITRFCSGAAPQFPMKKVVLLLWKVSLLGLGGMDVLKNLKNEYRLK 318
            .|:.|||.:.|.::|.|.||:|:||||.||.||||||:|||||..|..|||.:.|::.|...|..
Zfish   225 SELGSPLYNHEPVSVMLFGMVTKFCSGHAPHFPMKKVLLLLWKTILFTLGGFEQLQSCKISRRAA 289

  Fly   319 VGLEPITEDTLEVTKCMRASSPPATATDILENQYPK-RNFKRSLMKQRFLD-----EPEQIDMEM 377
            :||.|:.||::.|.:.|||:||||:|:|::|.|..: |...::|:||..||     :|.:.| :.
Zfish   290 LGLPPLPEDSIRVVRSMRAASPPASASDLIEQQQRRARREHKALIKQDNLDTFNEKDPYKAD-DS 353

  Fly   378 GGNEGQNNANNGSGNGGNGEEELSQYYRPYDDPSSSASTTSTANPNNQPSLTQPPAAVPPVQ--- 439
            ..:|.:|:.|:.|...           .|:              |..:..:..||...||.:
Zfish   354 HEDEEENDDNDNSLEA-----------EPF--------------PLERDEVMPPPIPHPPTERMC 393

  Fly   440 ITARLPWTPKVRQKDIDQFLDISRNKFIGYSLIGDHESLAGLPQPIHEGFKTLQRHMYMSLADVQ 504
            ....|||.||||:|||:.||:.||:|||||:|..|.:::.|||:||||..|||::|.|:|:|:||
Zfish   394 FPKGLPWAPKVREKDIESFLESSRSKFIGYTLGNDTDTVVGLPRPIHESIKTLKQHKYVSIAEVQ 458

  Fly   505 IKKEEDIARNPISTHEDEIKLTPAEVLYQAILPNLPQYMIALLKVLLAASPTSKSKTESINIMAD 569
            |.|||:..:.|:|..|:|::|...|:|||.|||:||||||||||:||||:||||:||:||||:||
Zfish   459 IAKEEEFQKTPLSGGEEELELCATELLYQGILPSLPQYMIALLKILLAAAPTSKAKTDSINILAD 523

  Fly   570 VLPRKMPLTATQSTKLTVDIGRHKEIIVKAVSAIILLYLKHFKINHVYQFEFMSQHLVFANCIPL 634
            |||.:||.|..||.||.||:.|||||||||:|||:||.|||||:|||||||:|:|||||||||||
Zfish   524 VLPEEMPTTVLQSMKLGVDVNRHKEIIVKAISAILLLLLKHFKLNHVYQFEYMAQHLVFANCIPL 588

  Fly   635 VLKFFNQTITEYVNTKNSIPLLDFPSCVIGEQPDLSGDSFVYGGEMSDKSYSWRNVFSCINLLRI 699
            :||||||.|..|:..||||..||||.|||.|.|:|:.:|...|   .:..:.|||:|||||||||
Zfish   589 ILKFFNQNIMSYITAKNSISALDFPHCVIHELPELTAESLEAG---DNNQFCWRNLFSCINLLRI 650

  Fly   700 LNKLIKWKHSRVMMLVVFKSAPILKKTLKVRHAMMQLYVLKLLKMQTKYLGRQWRKSNMKTMSAI 764
            ||||.||||||.|||||||||||||:.|||:.||||||||||||:||||||||||||||||||||
Zfish   651 LNKLTKWKHSRTMMLVVFKSAPILKRALKVKQAMMQLYVLKLLKVQTKYLGRQWRKSNMKTMSAI 715

  Fly   765 YAKVRHRLNDDWAFGN-DLESRPWDFQAEECTLRACVDRFNLRRYPEATQKCGNNGTAAQNAENA 828
            |.|||||||||||:|| ||::||||||||||.|||.::|||.|||                  :.
Zfish   716 YQKVRHRLNDDWAYGNADLDARPWDFQAEECALRANIERFNSRRY------------------DK 762

  Fly   829 QQSNMMAGNNGCGNNGDANGYGNNGGGGNGGHNQQQQLNDYGVEGGFPSDEILTHSDFAFFGHSG 893
            .|||                                       ....|.|..|.    :..|
Zfish   763 NQSN---------------------------------------PEFLPVDNCLQ----SVLG--- 781

  Fly   894 WWDRKVELTDYFKANYAVWLEEEVYNSQTDWDAL 927
               ::::|.:.|:.||.:|||.||::....|:.|
Zfish   782 ---QRIDLPEDFQMNYDLWLEREVFSKPISWEEL 812

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Strip	NP_647806.2	N1221	69..344	CDD:285201	124/276 (45%)
Strip	NP_647806.2	DUF3402	482..826	CDD:288715	235/344 (68%)
strip1	XP_009294388.1	N1221	41..311	CDD:285201	120/272 (44%)
strip1	XP_009294388.1	DUF3402	436..763	CDD:288715	235/347 (68%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170595343
Domainoid	1	1.000	246	1.000	Domainoid score	I2130
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H35064
Inparanoid	1	1.050	809	1.000	Inparanoid score	I466
OMA	1	1.010	-	-		QHG46345
OrthoDB	1	1.010	-	-		D1095402at2759
OrthoFinder	1	1.000	-	-		FOG0002394
OrthoInspector	1	1.000	-	-		otm25090
orthoMCL	1	0.900	-	-		OOG6_103643
Panther	1	1.100	-	-	O	PTHR13239
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2109
SonicParanoid	1	1.000	-	-		X2094
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	14	13.940