DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Strip and Strip2

DIOPT Version :9

Sequence 1:	NP_647806.2	Gene:	Strip / 38412	FlyBaseID:	FBgn0035437	Length:	927	Species:	Drosophila melanogaster
Sequence 2:	XP_038964938.1	Gene:	Strip2 / 500066	RGDID:	1588437	Length:	844	Species:	Rattus norvegicus

Alignment Length:	892	Identity:	405/892 - (45%)
Similarity:	568/892 - (63%)	Gaps:	108/892 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    52 RASVDTDTHDADANCDGPDLDFVYADVDGYQNEIAELYSYTEFSEFQMNVKAFED--QMELYDLP 114
            |.:......:::.:.|.|.|:|.|.|.||:..|::|||||||..||..|.|.||:  :.::.| .
  Rat    41 REAFRNQRRESEGSVDCPTLEFEYGDADGHAAELSELYSYTESLEFTTNRKCFEEDFKTQVQD-T 104

  Fly   115 PNWQKQDSASQRGIVMKLVDQLEVSDRSFRMQAARCILYLAQGCWAEVQSDEEQHQITRDNVLVL 179
            ..|.:.:..:|:..||.|:|:|||..|..|::.||.:||||||.:.|..|:.:....:|.|..:|
  Rat   105 KEWLELEEDAQKTYVMGLLDRLEVVSREQRLKVARAVLYLAQGTFGECDSEVDVLHWSRYNCFLL 169

  Fly   180 YQLGVFASFIDLLNMEIESACSPDIVAVKITNVTLVDSTDIRVILSVLYIITETIRDEKEKGSED 244
            |::|.|::|::||:|||::: .....|::...|::.|||::||:|||:|::.|.||.|:|.....
  Rat   170 YRMGTFSAFLELLHMEIDNS-QASSSALRKPAVSIADSTELRVLLSVMYLMVENIRLEREIDPCG 233

  Fly   245 YRELADSFVQEINSPLPDGELLAVKLLGMITRFCSGAAPQFPMKKVVLLLWKVSLLGLGGMDVLK 309
            :|...::|..|::....:.|..|:.|..|:|:||||.||.||:|||:||||||.:..|||.:.|:
  Rat   234 WRTARETFRTELSFSTHNEEPFALLLFSMVTKFCSGLAPHFPIKKVLLLLWKVVMFTLGGFEHLQ 298

  Fly   310 NLKNEYRLKVGLEPITEDTLEVTKCMRASSPPATATDILENQYP--------KRNFKRSLM-KQR 365
            .||.:.|.::||.|:.||:::|.|.|||:|||:...|:.|:|..        :|..:|.|: ||.
  Rat   299 ALKIQKRAELGLPPLAEDSIQVVKSMRAASPPSYTLDLGESQLAPPPSKLRGRRGSRRQLLTKQD 363

  Fly   366 FLDEPEQIDM----EMGGNEGQNNANNGSGNGGNGEEELSQYYRPYDDPSSSASTTSTANPNNQP 426
            .||...:.|:    |....|.:.:|::|. ...:||.:|.:                 .:|...|
  Rat   364 SLDIYNERDLFKTEEPATEEEEESASDGE-RTLDGELDLLE-----------------QDPLVPP 410

  Fly   427 SLTQPPAAVPPVQITARLPWTPKVRQKDIDQFLDISRNKFIGYSLIGDHESLAGLPQPIHEGFKT 491
            ..:|.|.:...|.....|||.||||||||:.||::|||||||::|..|.::|.|||:||||..||
  Rat   411 PPSQTPLSADRVSFPKGLPWAPKVRQKDIEHFLEMSRNKFIGFTLGQDTDTLVGLPRPIHESVKT 475

  Fly   492 LQRHMYMSLADVQIKKEEDIARNPISTHEDEIKLTPAEVLYQAILPNLPQYMIALLKVLLAASPT 556
            |::|.|:|:||||||.||::.:.|:|..|:.|..||:|:|||.:|.:||||||||||:||||:||
  Rat   476 LKQHKYISIADVQIKNEEELEKCPMSLGEEVIPETPSEILYQGMLYSLPQYMIALLKILLAAAPT 540

  Fly   557 SKSKTESINIMADVLPRKMPLTATQSTKLTVDIGRHKEIIVKAVSAIILLYLKHFKINHVYQFEF 621
            ||:||:||||:|||||.:||.|..||.||.:|:.||||||||::||::||.|||||:||:||||:
  Rat   541 SKAKTDSINILADVLPEEMPATVLQSMKLGIDVNRHKEIIVKSISALLLLLLKHFKLNHIYQFEY 605

  Fly   622 MSQHLVFANCIPLVLKFFNQTITEYVNTKNSIPLLDFPSCVIGEQPDLSGDSFVYGGEMSDKS-Y 685
            ::|||||||||||:||||||.|..|:..||||.:||:|.|.|.:.|:|:.:|.    |..|.| :
  Rat   606 VAQHLVFANCIPLILKFFNQNILSYITAKNSISVLDYPCCTIQDLPELTTESL----EAGDNSQF 666

  Fly   686 SWRNVFSCINLLRILNKLIKWKHSRVMMLVVFKSAPILKKTLKVRHAMMQLYVLKLLKMQTKYLG 750
            .|||:||||||||:||||.||||||.|||||||||||||:.|||:.||:|||||||||:||||||
  Rat   667 CWRNLFSCINLLRLLNKLTKWKHSRTMMLVVFKSAPILKRALKVKQAMLQLYVLKLLKIQTKYLG 731

  Fly   751 RQWRKSNMKTMSAIYAKVRHRLNDDWAFGNDLESRPWDFQAEECTLRACVDRFNLRRYPEATQKC 815
            |||||||||||||||.|||||:|||||:|||:::||||||||||||||.::.||.|||.:
  Rat   732 RQWRKSNMKTMSAIYQKVRHRMNDDWAYGNDIDARPWDFQAEECTLRANIEAFNSRRYDK----- 791

  Fly   816 GNNGTAAQNAENAQQSNMMAGNNGCGNNGDANGYGNNGGGGNGGHNQQQQLNDYGVEGGFPSDEI 880
                  .|::|.:...|.:....|
  Rat   792 ------PQDSEFSPVDNCLQSVLG----------------------------------------- 809

  Fly   881 LTHSDFAFFGHSGWWDRKVELTDYFKANYAVWLEEEVYNSQTDWDAL 927
                            ::::|.:.|..:|.:|||.||::....|:.|
  Rat   810 ----------------QRLDLPEDFHYSYELWLEREVFSQPICWEEL 840

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Strip	NP_647806.2	N1221	69..344	CDD:285201	116/276 (42%)
Strip	NP_647806.2	DUF3402	482..826	CDD:288715	226/344 (66%)
Strip2	XP_038964938.1	N1221	58..305	CDD:400327	102/248 (41%)
Strip2	XP_038964938.1	DUF3402	466..792	CDD:403177	225/340 (66%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	248	1.000	Domainoid score	I2069
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	819	1.000	Inparanoid score	I442
OMA	1	1.010	-	-		QHG46345
OrthoDB	1	1.010	-	-		D1095402at2759
OrthoFinder	1	1.000	-	-		FOG0002394
OrthoInspector	1	1.000	-	-		otm44919
orthoMCL	1	0.900	-	-		OOG6_103643
Panther	1	1.100	-	-	LDO	PTHR13239
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X2094
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	11	10.980