DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Strip and SPBC27B12.04c

DIOPT Version :9

Sequence 1:	NP_647806.2	Gene:	Strip / 38412	FlyBaseID:	FBgn0035437	Length:	927	Species:	Drosophila melanogaster
Sequence 2:	NP_595536.1	Gene:	SPBC27B12.04c / 2540495	PomBaseID:	SPBC27B12.04c	Length:	817	Species:	Schizosaccharomyces pombe

Alignment Length:	868	Identity:	184/868 - (21%)
Similarity:	319/868 - (36%)	Gaps:	199/868 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    61 DADANCDGPDLDFVYADVDGYQNEIAELYSYTEFSEFQMNVKAFEDQMELY------DLPPNWQK 119
            |:.|:...| ::|.....|..::::...:...|......| |.|..::.:|      .|..||..
pombe    22 DSPASKHKP-MEFKGTSKDDLEDDLNSFFDCEEELFLSAN-KIFYSKLRVYQTVRHWSLKQNWSS 84

  Fly   120 QDSASQRGIVMKLVDQLEVSDRSFRMQAARCILYLAQGCWAEVQSDEEQHQITRDNVLVLYQLG- 183
            .....:|..::....:|. |....|..|...|||:|.|.:..|.|.||......:||.:|.:..
pombe    85 MSLDQKRNFILHCHHELS-SGELLRNSALYSILYIAAGAYDSVGSFEEHVHSISENVYLLREFDI 148

  Fly   184 ---VFASFIDLLNMEIESACSPDIVAVKITNVTLVDSTD---IRVILSVLYIITETIRDEKEKGS 242
               |::.||:.......|              .|.:|.|   :.::||:::........:|
pombe   149 PKTVYSLFIEWNRTRKHS--------------FLDNSRDEGFLNLLLSLMFFFLTLNNTDK---- 195

  Fly   243 EDYRELADSFVQEINSPLPDGELLAVKLLGMIT---RFCSGAAPQFPMKKVVLLLWKVSLLGLGG 304
                    :::..|.|..|......|||...||   :..........:||:..|::||.:...|.
pombe   196 --------TWIHSIRSLNPPVLPTLVKLFIDITSDYQLNLDKVIHSSLKKLSFLIFKVCIRLWGS 252

  Fly   305 MDVLKNLKNEYRLKVGLEPITEDTLEVTKCMRASSPPATATDILENQYPKRNFKRSLMKQRFLDE 369
            ...|:      ..|.||..:...:....|      |..||.|     |.....:.:.....|.|.
pombe   253 QSYLQ------EKKAGLAEVLNISTSQQK------PKTTALD-----YEVFRHEMATKFSSFADS 300

  Fly   370 --PEQIDMEMGGNEGQNNANNGSGNGGNGEEELSQYYRPYDDPSSSASTTSTANPNNQPSLTQPP 432
              |..:|.|........|.::              :::     ||..|:|...:|.| |||....
pombe   301 YYPVPLDREQAHILPTLNTDS--------------FHK-----SSFISSTRLCSPEN-PSLLVNT 345

  Fly   433 AAVPPVQITARLPWTPKVRQKDIDQFLDISRNKFIGYSLIGDHESLAGLPQPIHEGFKTLQRHMY 497
            |...  :::||.           :||   ..|:.:.:....:.|.|. :|..:.|.....|....
pombe   346 AKTS--KMSARR-----------EQF---QTNQNLPFCFTPNLEKLT-IPYSVTEAANVFQNKTK 393

  Fly   498 MSLADVQIKKEEDIAR--------------------NPISTHEDE---IKLTPAEVLYQAILP-- 537
            .:||..|:..|.::.|                    .|..:.|.|   :|.....  |..:.|
pombe   394 RTLAVEQLLSERELLRRFTLQQRLVADLHEFYNSVKGPAHSFETEDPVLKFVSQS--YDDLFPYM 456

  Fly   538 -NLPQYMIALL-----KV---LLAASPTSKSKTESI--NIMADVLPRKMPLTATQSTKLTVDIG- 590
             |..|..:.|.     ||   .:.|..:|.:..:.|  |.:.|....::...|.::.|..|.|.
pombe   457 DNFIQLAVQLFYHISKKVNCLYVEAFSSSDAVLQRIQDNAVVDSPTEELSEQAARNRKSNVKIEY 521

  Fly   591 ------------------RHKEIIVKAVSAIILLYLKHFKINHVYQFEFMSQHLVFANCIPLVLK 637
                              .:.|.::.::|::.|:.||.|:::||.:||.:: .|::.|..   |:
pombe   522 TEDFATGFAISGEISHSINNLEFVLYSLSSLFLMMLKWFRLSHVLRFERLA-FLLYENHF---LE 582

  Fly   638 FFNQTITE---YVNTKNSIPLLDFPSCVIGEQPDLSGDSFVYGGEM----------SDKSYSWRN 689
            .||:.:||   ..||:..:      .||       .|..|.|..:|          ..::.|.||
pombe   583 IFNRHLTEGDCNRNTEKDV------KCV-------RGGFFSYSSKMYKYDRVSIPVITRASSSRN 634

  Fly   690 VFSCINLLRILNKLIKWKHSRVMMLVVFKSAPILKKTLKVRHAMMQLYVLKLLKMQTKYLGRQWR 754
            :...:|.||:|.|:.|:.:.|..::........|||.|.:.|..::||.||:||:...:||.:|:
pombe   635 LLITMNCLRVLEKVCKYSNIRKEIIARSNLHENLKKLLAIPHDKLRLYALKVLKLSVPFLGLKWK 699

  Fly   755 KSNMKTMSAIYAKVRHRLNDDWAFGNDLESRPWDFQAEECTLRACVDRFNLRRYPEATQKCGN-- 817
            ::||..::.||......|.|.|.|..:........|.:|..|...:..:::|.|   .:||.:
pombe   700 QANMSIITQIYLNCSLDLRDSWMFHENGSDTYRSAQLQETFLAILIRFYHIRLY---GKKCKSLY 761

  Fly   818 ------NGTAAQNAENAQQSNMM 834
                  .....::.|....||||
pombe   762 QFCILEEMRLKKSIEELAASNMM 784

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Strip	NP_647806.2	N1221	69..344	CDD:285201	58/290 (20%)
Strip	NP_647806.2	DUF3402	482..826	CDD:288715	92/419 (22%)
SPBC27B12.04c	NP_595536.1	N1221	30..308	CDD:285201	65/323 (20%)
SPBC27B12.04c	NP_595536.1	DUF3402	378..769	CDD:288715	92/412 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	69	1.000	Domainoid score	I2696
eggNOG	1	0.900	-	-		E1_KOG3680
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	120	1.000	Inparanoid score	I1498
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0002394
OrthoInspector	1	1.000	-	-		oto100825
orthoMCL	1	0.900	-	-		OOG6_103643
Panther	1	1.100	-	-	LDO	PTHR13239
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2109
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	9	8.980