DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Strip and farl-11

DIOPT Version :9

Sequence 1:	NP_647806.2	Gene:	Strip / 38412	FlyBaseID:	FBgn0035437	Length:	927	Species:	Drosophila melanogaster
Sequence 2:	NP_001333549.1	Gene:	farl-11 / 174165	WormBaseID:	WBGene00017349	Length:	978	Species:	Caenorhabditis elegans

Alignment Length:	982	Identity:	324/982 - (32%)
Similarity:	495/982 - (50%)	Gaps:	193/982 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    60 HDADANCDG--PDLDFVYADVDGYQNEIAELYSYTEFSEFQMNVKAFEDQM-ELYD-----LPPN 116
            |::..|...  .||||.|.|.|....|:||||||:|..||.:|:..:::.: |.||     .|..
Worm    65 HESSDNVAAIDKDLDFEYGDGDAGIREMAELYSYSEIEEFGINISNWKEYIEESYDGKHEQFPST 129

  Fly   117 WQKQDSASQRGIVMKLVDQLEVSDRSFRMQAARCILYLAQGCWAE---VQSDEEQHQITR----- 173
            :::..:..:..::..|..::|.:|...|:::||.||:|.||...:   ::::|.::|..:
Worm   130 FEEFSAVQKNYVIQDLCSRMESADLEVRLKSARIILFLLQGSATDFGCLENEEIEYQYDQKLLMN 194

  Fly   174 ----------------------DNVLVLYQLGVFASFIDLLNMEIE----------------SAC 200
                                  :|..:.|:.||:.:...||..||:                |..
Worm   195 VPIRKTKEMDPEGPSMVYHRAIENSFICYKNGVYQALCTLLMTEIKEPFESPPNDGRISKASSRS 259

  Fly   201 SPDIVAVKITN---------VTLVDSTDIRVILSVLYIITETIRDEKEKGSEDYR----ELADSF 252
            |.:.....:::         .|:||:..:||||:.||.:...|.||: .|.||..    |...:|
Worm   260 SRNASLADLSDSEKWRTRQLPTMVDNEMLRVILAGLYHMIVQILDER-SGREDETDSDLETRKAF 323

  Fly   253 VQEINSPLPDG-ELLAVKLLGMITRFCSGAAPQFPMKKVVLLLWKVSLLGLGGMDVLKNLKNEYR 316
            .:|:..|:.:| |.|.:.|..|:..|..|.||.||:||:|||:||:.||.|||.:.|...|.|.|
Worm   324 REEVQEPIENGNEPLLIVLFDMLHPFYIGTAPHFPIKKIVLLIWKILLLTLGGWEELTVRKREKR 388

  Fly   317 LKVGLEPITEDTLEVTKCMRASSPPATATDILENQYPKRN-------FKRSLMKQRFLDEPEQID 374
            :..||: |.|||:.|.        .:.|..|.::|...||       |.|..|..|
Worm   389 MTAGLD-IMEDTITVA--------ASQAAFIAKDQEHVRNMAHRAGSFARGGMMAR--------- 435

  Fly   375 MEMGGNEGQNNANNGSGNGGNGEEELSQYYRPYDDPSSSAST----TSTANPNNQPSLTQPP--- 432
             :|..|:   ::.:.........|:.:...:..|.|.:|:||    ..||:...|.|..|.|
Worm   436 -QMAYND---DSKDEDAYSEASSEDSTIASKKEDSPGASSSTPPSIPDTASNFRQGSGEQTPRVG 496

  Fly   433 AAVPPVQITARLPWTPKVRQKDIDQFLDISRNKFIGYSL-IGDHESLAGLPQPIHEGFKTLQRHM 496
            :.|.||.....|||..|...:||:.|:...|.|:..|.. .||..:|.|||.......|.|:.:|
Worm   497 SPVFPVIQKKTLPWRSKTNAQDIEDFIQKGRFKYFNYDFDPGDDTTLFGLPPSFCGAVKILRNNM 561

  Fly   497 YMSLADVQIKKEEDIARNPISTHEDEIKLTPAEVLYQAILPNLPQYMIALLKVLLAASPTSKSKT 561
            |.||.::|:||:|::.|...|..|| |..|..|.||:.|||||.||:.||:||::::.|::|::.
Worm   562 YTSLTELQVKKDEELNRYLFSMKED-IPETKTETLYRKILPNLSQYICALVKVMVSSVPSTKARH 625

  Fly   562 ESINIMADVLPRKM--------PLTATQST--------KLTVDIGRHKEIIVKAVSAIILLYLKH 610
            |.:|::.|.|..:|        .::...||        :|.:||.||||||||::|||:||.:||
Worm   626 EGLNVLIDCLTPEMEASDILSNSISLDNSTSSPLEEGFRLAIDINRHKEIIVKSLSAILLLLVKH 690

  Fly   611 FKINHVYQFEFMSQHLVFANCIPLVLKFFNQTITEYVNTKNSIPLLDFPSCVI------GEQPDL 669
            ||:||:||||::.|.:|:.|.|||:|||.:|...:.:.:::.|...::|.|:.      .|.|.|
Worm   691 FKLNHIYQFEYICQQIVYVNGIPLILKFLDQNTNKLIQSRHEIYAYNYPQCLYHYVRNNEEWPIL 755

  Fly   670 SGDSFVYGGEMSDKSY-SWRNVFSCINLLRILNKLIKWKHSRVMMLVVFKSAPILKKTLKVRHAM 733
            :.|:...........| .|||||..|||:|:||||:|.|:.||.||:||||||:||:..|||.::
Worm   756 TQDNIEEPRPPGAGPYFMWRNVFFAINLIRLLNKLVKAKNDRVKMLMVFKSAPVLKRLFKVRVSV 820

  Fly   734 MQLYVLKLLKMQTKYLGRQWRKSNMKTMSAIYAKVRHRLNDDWAFGNDLESRPWDFQAEECTLRA 798
            :||||||.:|||::|||||||||||..:||||::||||:.|||||.:|:: |..|:|.|:..::|
Worm   821 LQLYVLKAIKMQSRYLGRQWRKSNMDIISAIYSRVRHRMTDDWAFASDIK-RKCDYQKEDSLIKA 884

  Fly   799 CVDRFNLRRYPEATQKCGNNGTAAQNAENAQQSNMMAGNNGCGNNGDANGYGNNGGGGNGGHNQQ 863
            .::||:.|||            :|...:.|.:.|
Worm   885 SIERFHSRRY------------SALYPQFAIEVN------------------------------- 906

  Fly   864 QQLNDYGVEGGFPSDEILTHSDFAFF------GHS--GWWDRKVELTDYFKANYAVWLEEEVYNS 920
                    :...|.|:.|...|...|      .||  |   ..::|..:||.:|..|||:||:|:
Worm   907 --------DAPMPGDDYLNRVDMRDFEPVDTCAHSVLG---ANLKLGRHFKKDYEKWLEQEVFNA 960

  Fly   921 QTDWDAL 927
            ..|||.|
Worm   961 SIDWDKL 967

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Strip	NP_647806.2	N1221	69..344	CDD:285201	98/340 (29%)
Strip	NP_647806.2	DUF3402	482..826	CDD:288715	159/366 (43%)
farl-11	NP_001333549.1	N1221	77..405	CDD:369597	98/337 (29%)
farl-11	NP_001333549.1	DUF3402	553..924	CDD:371779	164/423 (39%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160166802
Domainoid	1	1.000	161	1.000	Domainoid score	I2455
eggNOG	1	0.900	-	-		E1_KOG3680
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	472	1.000	Inparanoid score	I833
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG46345
OrthoDB	1	1.010	-	-		D1095402at2759
OrthoFinder	1	1.000	-	-		FOG0002394
OrthoInspector	1	1.000	-	-		oto20269
orthoMCL	1	0.900	-	-		OOG6_103643
Panther	1	1.100	-	-	LDO	PTHR13239
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2109
SonicParanoid	1	1.000	-	-		X2094
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	15	14.800