DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Strip and strip2

DIOPT Version :9

Sequence 1:	NP_647806.2	Gene:	Strip / 38412	FlyBaseID:	FBgn0035437	Length:	927	Species:	Drosophila melanogaster
Sequence 2:	XP_012815507.1	Gene:	strip2 / 100491814	XenbaseID:	XB-GENE-980643	Length:	788	Species:	Xenopus tropicalis

Alignment Length:	875	Identity:	396/875 - (45%)
Similarity:	547/875 - (62%)	Gaps:	109/875 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    61 DADANCDGPDLDFVYADVDGYQNEIAELYSYTEFSEFQMNVKAFEDQMELYDLPPNWQKQDSASQ 125
            :::|:.|..:::|||.|.|....|:||||||||..:..:|...||::.:.:.....|....||..
Frog    11 ESEASLDSSNVEFVYDDTDHPYTELAELYSYTEEQDLNLNRNCFEEEFKDHVNDLRWTSLTSAEH 75

  Fly   126 RGIVMKLVDQLEVSDRSFRMQAARCILYLAQGCWAEVQSDEEQHQITRDNVLVLYQLGVFASFID 190
            |..:|.|:|:|||.:|..|:.|:|.||||:||.:.|..::.:..:.::.|..:||.:|.||:|::
Frog    76 RIYIMHLLDKLEVVNREKRLSASRAILYLSQGVFGECDNEADVVRWSKYNSFLLYNMGAFAAFLE 140

  Fly   191 LLNMEI--ESACSPDIVAVKITNVTLVDSTDIRVILSVLYIITETIRDEKEKGSEDYRELADSFV 253
            ||||||  ..|||.   |::...::|.||||:||:|||:|::.|.||.|.|....:::.|..:|.
Frog   141 LLNMEIANSQACSS---ALRKPALSLADSTDLRVLLSVMYLMVENIRQESENDDPEWKILRANFR 202

  Fly   254 QEINSPLPDGELLAVKLLGMITRFCSGAAPQFPMKKVVLLLWKVSLLGLGGMDVLKNLKNEYRLK 318
            :|:..|:...|..|..|..|:|:||||..|.||||||:||||||.|..|||...|:::|.:.|.:
Frog   203 EELAFPVHPEEPFAHLLFAMVTKFCSGHCPHFPMKKVLLLLWKVLLFTLGGFPELQSMKEKKRSE 267

  Fly   319 VGLEPITEDTLEVTKCMRASSPPATATDILENQYPKRNFKRSLMKQRFLDEPEQIDMEMGGNEGQ 383
            :||.|:.||:::|.|.|:|.|||....::.|.|...|..:|           :.:|:....:..:
Frog   268 LGLPPLLEDSIQVMKNMKAISPPTYGIELGEQQKRGRRSRR-----------DSLDLYNEKDPFK 321

  Fly   384 NNANNGSGNGGNGEEELSQYYRPYDDPSSSASTTSTANPNNQPS--LTQPPAAV----PPVQITA 442
            |:...|                |.::.|..........|..|..  |:||.|::    ..|....
Frog   322 NDELQG----------------PEEEESEETDNMMDTEPEAQEKDLLSQPLASLRANSERVCFPK 370

  Fly   443 RLPWTPKVRQKDIDQFLDISRNKFIGYSLIGDHESLAGLPQPIHEGFKTLQRHMYMSLADVQIKK 507
            .|||.||||:|||:.||::|||||||::|..|.|:|.|||:||||..|||::|.|:|:|||||||
Frog   371 GLPWPPKVREKDIENFLEMSRNKFIGFTLGNDTETLVGLPRPIHESVKTLKQHKYVSVADVQIKK 435

  Fly   508 EEDIARNPISTHEDEIKLTPAEVLYQAILPNLPQYMIALLKVLLAASPTSKSKTESINIMADVLP 572
            ||::.:.|:...:::::.||.|:||:::|.|:|||||||||:||||:||||:||:||||:|||||
Frog   436 EEELEKCPMLLGQEKVEETPCELLYKSMLTNIPQYMIALLKILLAAAPTSKAKTDSINILADVLP 500

  Fly   573 RKMPLTATQSTKLTVDIGRHKEIIVKAVSAIILLYLKHFKINHVYQFEFMSQHLVFANCIPLVLK 637
            .:||:|..||.||.:|:.||||||||:||||:||.|||||:||::|||::||||||||||||:||
Frog   501 EEMPITILQSMKLGIDVNRHKEIIVKSVSAILLLLLKHFKLNHIFQFEYVSQHLVFANCIPLILK 565

  Fly   638 FFNQTITEYVNTKNSIPLLDFPSCVIGEQPDLSGDSFVYGGEMSDKSYSWRNVFSCINLLRILNK 702
            ||||.|..|:..||||..|:|||||:.|.|:|:.:|...|   .:..:.|||:|||||||:||||
Frog   566 FFNQNIMSYICAKNSISALEFPSCVVHELPELTAESLETG---DNNQFCWRNLFSCINLLKILNK 627

  Fly   703 LIKWKHSRVMMLVVFKSAPILKKTLKVRHAMMQLYVLKLLKMQTKYLGRQWRKSNMKTMSAIYAK 767
            |.||||||.|||||||||||||:.|||:.|::|||||||||:|||||||||||||||||||||..
Frog   628 LTKWKHSRTMMLVVFKSAPILKRALKVKQAILQLYVLKLLKLQTKYLGRQWRKSNMKTMSAIYQL 692

  Fly   768 VRHRLNDDWAFGNDLESRPWDFQAEECTLRACVDRFNLRRYPEATQKCGNNGTAAQNAENAQQSN 832
            ||||:|||||:|||:::|||||||||||||..::|||.|||.:           ..:.|.|...|
Frog   693 VRHRMNDDWAYGNDIDARPWDFQAEECTLRGNIERFNSRRYEK-----------NPSWEFAPVDN 746

  Fly   833 MMAGNNGCGNNGDANGYGNNGGGGNGGHNQQQQLNDYGVEGGFPSDEILTHSDFAFFGHSGWWDR 897
            .:....|                                                         :
Frog   747 CLLSVVG---------------------------------------------------------Q 754

  Fly   898 KVELTDYFKANYAVWLEEEVYNSQTDWDAL 927
            .:||...|...|.:|||.||::....|:.|
Frog   755 TLELPGDFHYTYELWLEREVFSKPIHWEEL 784

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Strip	NP_647806.2	N1221	69..344	CDD:285201	116/276 (42%)
Strip	NP_647806.2	DUF3402	482..826	CDD:288715	222/343 (65%)
strip2	XP_012815507.1	N1221	19..>236	CDD:369597	86/219 (39%)
strip2	XP_012815507.1	DUF3402	410..736	CDD:371779	222/339 (65%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	244	1.000	Domainoid score	I2159
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	811	1.000	Inparanoid score	I474
OMA	1	1.010	-	-		QHG46345
OrthoDB	1	1.010	-	-		D1095402at2759
OrthoFinder	1	1.000	-	-		FOG0002394
OrthoInspector	1	1.000	-	-		otm47969
Panther	1	1.100	-	-	LDO	PTHR13239
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X2094
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	10	10.080