DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG12016 and ctnnb2

DIOPT Version :9

Sequence 1:	NP_647805.1	Gene:	CG12016 / 38411	FlyBaseID:	FBgn0035436	Length:	323	Species:	Drosophila melanogaster
Sequence 2:	NP_001001889.1	Gene:	ctnnb2 / 324004	ZFINID:	ZDB-GENE-040426-2575	Length:	778	Species:	Danio rerio

Alignment Length:	188	Identity:	40/188 - (21%)
Similarity:	66/188 - (35%)	Gaps:	61/188 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 ISGVTCGGKTTLAHSLHD--YFKGLRGAPLW----NSP------YTIGEVRLISQD--------- 52
            :.|.| |....||..:|:  ..:||...||:    .||      ...|.:..::||
Zfish   569 VEGCT-GALHILARDVHNRIVIRGLNTIPLFVQLLYSPIENIQRVAAGVLCELAQDKEAAEAIEA 632

  Fly    53 -DYFLPVEDKRHQRNEAL--------------------NAINFELITSLDMAKML--NDIAHIIK 94
             ....|:.:..|.|||.:                    ..::.||.:||...:.:  |:.|.:
Zfish   633 EGATAPLTELLHSRNEGVATYAAAVLFRMSEDKPQDYKKRLSVELTSSLFRTEPMAWNETADL-- 695

  Fly    95 GRHVAPEPQEHLVTYANFEHYAQQFQQQYQYNANYYKQANG--GVYQYPPQQHPRHHP 150
            |..:. .|.|.|...|:...|.       .:::.|..:|.|  |:.    :|...|||
Zfish   696 GLDIG-APGETLAYRADEPSYR-------SFHSGYAAEALGMEGLL----EQEMSHHP 741

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG12016	NP_647805.1	NRK1	6..255	CDD:238982	40/188 (21%)
ctnnb2	NP_001001889.1	ARM	<151..221	CDD:237987
		armadillo repeat	152..177	CDD:293788
		armadillo repeat	187..220	CDD:293788
		ARM	228..347	CDD:237987
		armadillo repeat	229..261	CDD:293788
		armadillo repeat	269..305	CDD:293788
		armadillo repeat	311..346	CDD:293788
		ARM	349..389	CDD:214547
		armadillo repeat	353..388	CDD:293788
		ARM	398..517	CDD:237987
		armadillo repeat	401..426	CDD:293788
		armadillo repeat	434..472	CDD:293788
		armadillo repeat	481..516	CDD:293788
		ARM	483..622	CDD:237987	13/53 (25%)
		armadillo repeat	523..581	CDD:293788	4/12 (33%)
		armadillo repeat	586..620	CDD:293788	7/33 (21%)
		ARM	588..>667	CDD:237987	14/78 (18%)
		armadillo repeat	628..661	CDD:293788	5/32 (16%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0572
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900