Protein Alignment KPNA5 and Kap-alpha3

DIOPT Version :10

• Sequence 1: NP_001353233.1
• Gene: KPNA5 / 3841
• HGNCID: 6398
• Length: 559
• Species: Homo sapiens
• Sequence 2: NP_731377.1
• Gene: Kap-alpha3 / 41158
• FlyBaseID: FBgn0027338
• Length: 514
• Species: Drosophila melanogaster
• Alignment Length: 525
• Identity: 239/525 - (45%)
• Similarity: 328/525 - (62%)
• Gaps: 20/525 - (3%)

Human    33 RMKSYKNKALNPQEMRRRREEEGIQLRKQKREEQLFKRRNVYLPRNDESMLESPIQDPDISSTVP 97
            |::::|||..:..||||||.|..::|||.||||.:.|||||  |..|.:..|    :..:||::.
  Fly     8 RLQNFKNKGKDQDEMRRRRNEVTVELRKNKREETILKRRNV--PNLDSNTDE----EEQLSSSID 66

Human    98 IPEEEVVTTDMVQMIFSNNADQQLTATQKFRKLLSKEPNPPIDQVIQKPGVVQRFVKFLERNENC 162
            :.:......|      :...:|||.|.|..|||||.:.||||:.:||. .::...|:.|:::.:.
  Fly    67 LKKLAKAAAD------ATKPEQQLAAVQAARKLLSSDKNPPINDLIQS-DILPILVECLKQHNHT 124

Human   163 TLQFEAAWALTNIASGTFLHTKVVIETGAVPIFIKLLNSEHEDVQEQAVWALGNIAGDNAECRDF 227
            .||||||||||||||||...|..|:..||||:|::||||...:|.||||||||||.||....|||
  Fly   125 MLQFEAAWALTNIASGTSAQTNEVVAAGAVPLFLQLLNSPAPNVCEQAVWALGNIIGDGPLLRDF 189

Human   228 VLNCEILPPLLELLTNSNRLTTTRNAVWALSNLCRGKNPPPNFSKVSPCLNVLSRLLFSSDPDVL 292
            |:...::.|||..:.....:|..||..|.:.||||.|:|.|..:.:...|..|:.|:..:|.::|
  Fly   190 VIKHGVVQPLLSFIKPDIPITFLRNVTWVIVNLCRNKDPAPPTATIHEILPALNVLIHHTDTNIL 254

Human   293 ADVCWALSYLSDGPNDKIQAVIDSGVCRRLVELLMHNDYKVVSPALRAVGNIVTGDDIQTQVILN 357
            .|..||:|||:||.||:||.||:|||..:|:.||.:::.||.:.|||||||||||.|.||||:||
  Fly   255 VDTVWAISYLTDGGNDQIQMVIESGVVPKLIPLLGNSEVKVQTAALRAVGNIVTGSDEQTQVVLN 319

Human   358 CSALPCLLHLLSSPKESIRKEACWTVSNITAGNRAQIQAVIDANIFPVLIEILQKAEFRTRKEAA 422
            ..||.....|||.|||.|||||.|.:|||||||::|:||||:..:.|.:||.|.|.||:|:||||
  Fly   320 YDALSYFPGLLSHPKEKIRKEAVWFLSNITAGNQSQVQAVINVGLLPKIIENLSKGEFQTQKEAA 384

Human   423 WAITNATSGGTPEQIRYLVALGCIKPLCDLLTVMDSKIVQVALNGLENILRLGEQESKQNGIGIN 487
            |||:|.|..|..||:..|:..|.|.|.||||:..|::::.|.|:||.|:|::.:..       :.
  Fly   385 WAISNLTISGNREQVFTLIKEGVIPPFCDLLSCQDTQVINVVLDGLNNMLKVADSH-------VE 442

Human   488 PYCALIEEAYGLDKIEFLQSHENQEIYQKAFDLIEHYFGVEEDDPSIVPQVDENQQQFIFQQQEA 552
            .....|||..||.|||.||||||.|||:.|:::|:.||..|.:..::.|..|..|..|.......
  Fly   443 AVANCIEECEGLAKIERLQSHENVEIYKLAYEIIDQYFTDEGEQTNMAPTSDGAQYNFDPHADRL 507

Human   553 PMDGF 557
            .|:.|
  Fly   508 TMNSF 512

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
KPNA5	NP_001353233.1	SRP1	56..541	CDD:227396	224/484 (46%)
		armadillo repeat	142..175	CDD:293788	14/32 (44%)
		armadillo repeat	183..219	CDD:293788	22/35 (63%)
		armadillo repeat	225..260	CDD:293788	11/34 (32%)
		armadillo repeat	277..302	CDD:293788	9/24 (38%)
		armadillo repeat	310..346	CDD:293788	20/35 (57%)
		armadillo repeat	354..386	CDD:293788	18/31 (58%)
		armadillo repeat	394..430	CDD:293788	20/35 (57%)
		armadillo repeat	437..471	CDD:293788	13/33 (39%)
Kap-alpha3	NP_731377.1	SRP1	8..500	CDD:227396	236/511 (46%)
		armadillo repeat	104..137	CDD:293788	14/33 (42%)
		armadillo repeat	145..181	CDD:293788	22/35 (63%)
		armadillo repeat	187..222	CDD:293788	11/34 (32%)
		armadillo repeat	239..264	CDD:293788	9/24 (38%)
		armadillo repeat	272..308	CDD:293788	20/35 (57%)
		armadillo repeat	314..348	CDD:293788	20/33 (61%)
		armadillo repeat	356..390	CDD:293788	19/33 (58%)
		armadillo repeat	399..433	CDD:293788	13/33 (39%)