Protein Alignment KPNA5 and Kap-alpha1

DIOPT Version :10

• Sequence 1: NP_001353233.1
• Gene: KPNA5 / 3841
• HGNCID: 6398
• Length: 559
• Species: Homo sapiens
• Sequence 2: NP_524167.1
• Gene: Kap-alpha1 / 40160
• FlyBaseID: FBgn0024889
• Length: 543
• Species: Drosophila melanogaster
• Alignment Length: 540
• Identity: 335/540 - (62%)
• Similarity: 399/540 - (73%)
• Gaps: 26/540 - (4%)

Human    37 YKNKALNPQEMRRRREEEGIQLRKQKREEQLFKRRNVYL-PRND------ESMLESPIQDPDI-- 92
            |||.||:..||||||||.||||||.|||:||||||||.| |...      ||..::..|..|:
  Fly     9 YKNAALDSTEMRRRREEVGIQLRKNKREQQLFKRRNVVLEPATSSTSAGVESNTDNEQQAADMHM 73

Human    93 --SSTVPIPEE--------EVVTTDMVQMIFSNNADQQLTATQKFRKLLSKEPNPPIDQVIQKPG 147
              |||....||        .|:..:|:||:||...::||.||||||||||::|||||::|||| |
  Fly    74 ADSSTGGQNEEAAGSGAQPSVINEEMIQMLFSGRENEQLEATQKFRKLLSRDPNPPIEEVIQK-G 137

Human   148 VVQRFVKFLERNENCTLQFEAAWALTNIASGTFLHTKVVIETGAVPIFIKLLNSEHEDVQEQAVW 212
            :|.:||.||..:.|.||||||||.||||||||...||||||.|||||||.||:|.|:||||||||
  Fly   138 IVPQFVTFLRNSANATLQFEAAWTLTNIASGTSQQTKVVIEAGAVPIFIDLLSSPHDDVQEQAVW 202

Human   213 ALGNIAGDNAECRDFVLNCEILPPLLELLTNSNRLTTTRNAVWALSNLCRGKNPPPNFSKVSPCL 277
            ||||||||:..|||.:|...||.|||.:|:||:|:|..|||||.||||||||:||.:|:|:|..|
  Fly   203 ALGNIAGDSPMCRDHLLGSGILEPLLHVLSNSDRITMIRNAVWTLSNLCRGKSPPADFAKISHGL 267

Human   278 NVLSRLLFSSDPDVLADVCWALSYLSDGPNDKIQAVIDSGVCRRLVELLMHNDYKVVSPALRAVG 342
            .:|:|||..:|.|||:|.|||:.|||||||||||||||:||||||||||:|....|.:.||||||
  Fly   268 PILARLLKYTDADVLSDTCWAIGYLSDGPNDKIQAVIDAGVCRRLVELLLHPQQNVSTAALRAVG 332

Human   343 NIVTGDDIQTQVILNCSALPCLLHLLSSPKESIRKEACWTVSNITAGNRAQIQAVIDANIFPVLI 407
            |||||||.||||||..:||.|:.|||.|..|:|:||:|||:|||.||||.||||:|:|||||.|:
  Fly   333 NIVTGDDQQTQVILGYNALTCISHLLHSTAETIKKESCWTISNIAAGNREQIQALINANIFPQLM 397

Human   408 EILQKAEFRTRKEAAWAITNATSGGTPEQIRYLVALGCIKPLCDLLTVMDSKIVQVALNGLENIL 472
            .|:|.|||:||||||||||||||.||.|||.|||.:||:.|:||.|||:||.|||||||.|||||
  Fly   398 VIMQTAEFKTRKEAAWAITNATSSGTHEQIHYLVQVGCVPPMCDFLTVVDSDIVQVALNALENIL 462

Human   473 RLGEQESKQNGIGINPYCALIEEAYGLDKIEFLQSHENQEIYQKAFDLIEHYFGVEEDDPSIVPQ 537
            :.||:...:.    |||...|||..||||||:||:|||::||.|:|.:||.|||.||:|..:.|.
  Fly   463 KAGEKFQTRP----NPYAITIEECGGLDKIEYLQAHENRDIYHKSFYIIEQYFGNEEEDSRVAPV 523

Human   538 VDENQQQFIFQQQEAPMDGF 557
            .  ..|||.|.....|..||
  Fly   524 A--GTQQFEFDPDNMPSTGF 541

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
KPNA5	NP_001353233.1	SRP1	56..541	CDD:227396	314/503 (62%)
		armadillo repeat	142..175	CDD:293788	21/32 (66%)
		armadillo repeat	183..219	CDD:293788	30/35 (86%)
		armadillo repeat	225..260	CDD:293788	20/34 (59%)
		armadillo repeat	277..302	CDD:293788	13/24 (54%)
		armadillo repeat	310..346	CDD:293788	26/35 (74%)
		armadillo repeat	354..386	CDD:293788	18/31 (58%)
		armadillo repeat	394..430	CDD:293788	27/35 (77%)
		armadillo repeat	437..471	CDD:293788	23/33 (70%)
Kap-alpha1	NP_524167.1	SRP1	1..543	CDD:227396	335/540 (62%)
		armadillo repeat	133..165	CDD:293788	21/32 (66%)
		armadillo repeat	173..209	CDD:293788	30/35 (86%)
		armadillo repeat	215..250	CDD:293788	20/34 (59%)
		armadillo repeat	267..292	CDD:293788	13/24 (54%)
		armadillo repeat	300..336	CDD:293788	26/35 (74%)
		armadillo repeat	342..376	CDD:293788	20/33 (61%)
		armadillo repeat	384..421	CDD:293788	28/36 (78%)
		armadillo repeat	427..461	CDD:293788	23/33 (70%)