Protein Alignment KPNA5 and Pen

DIOPT Version :10

• Sequence 1: NP_001353233.1
• Gene: KPNA5 / 3841
• HGNCID: 6398
• Length: 559
• Species: Homo sapiens
• Sequence 2: NP_477041.1
• Gene: Pen / 34338
• FlyBaseID: FBgn0287720
• Length: 522
• Species: Drosophila melanogaster
• Alignment Length: 539
• Identity: 254/539 - (47%)
• Similarity: 338/539 - (62%)
• Gaps: 27/539 - (5%)

Human    26 SPGKDNYRMKSYKNKALNPQEMRRRREEEGIQLRKQKREEQLFKRRNVYLPRNDESMLESPIQDP 90
            |....|.|..|||..::|.|:.|.||.|..|:|||.|:|:|:|||||:    |||. |.||:::.
  Fly     2 SKADSNSRQGSYKANSINTQDSRMRRHEVTIELRKSKKEDQMFKRRNI----NDED-LTSPLKEL 61

Human    91 DISSTVPIPEEEVVTTDMVQMIFSNNADQQLTATQKFRKLLSKEPNPPIDQVIQKPGVVQRFVKF 155
            :..|.|.:..:|:|..     :.|.:.::|....|..||:||:|.|||||.:|.. |:|...::|
  Fly    62 NGQSPVQLSVDEIVAA-----MNSEDQERQFLGMQSARKMLSRERNPPIDLMIGH-GIVPICIRF 120

Human   156 LERNENCTLQFEAAWALTNIASGTFLHTKVVIETGAVPIFIKLLNSEHEDVQEQAVWALGNIAGD 220
            |:...|..||||||||||||||||...|:.|||..|||.|:.||.|:..::.|||||||||||||
  Fly   121 LQNTNNSMLQFEAAWALTNIASGTSDQTRCVIEHNAVPHFVALLQSKSMNLAEQAVWALGNIAGD 185

Human   221 NAECRDFVLNCEILPPLLELLTNSNRLTTTRNAVWALSNLCRGKNPPPNFSKVSPCLNVLSRLLF 285
            .|..||.|::..::..:|.|:.|...|:..||.||.:|||||.|||.|.|.:|...|.|||:||.
  Fly   186 GAAARDIVIHHNVIDGILPLINNETPLSFLRNIVWLMSNLCRNKNPSPPFDQVKRLLPVLSQLLL 250

Human   286 SSDPDVLADVCWALSYLSDGPNDKIQAVIDSGVCRRLVELLMHNDYKVVSPALRAVGNIVTGDDI 350
            |.|..||||.||||||::|..|.|||||:||....|||:||..::..::.||||:|||||||.|.
  Fly   251 SQDIQVLADACWALSYVTDDDNTKIQAVVDSDAVPRLVKLLQMDEPSIIVPALRSVGNIVTGTDQ 315

Human   351 QTQVILNCSALPCLLHLLSSPKESIRKEACWTVSNITAGNRAQIQAVIDANIFPVLIEILQKAEF 415
            ||.|::....||.|..||...|.:|.|||.||||||||||:.||||||.|.||..|..:|:|.:|
  Fly   316 QTDVVIASGGLPRLGLLLQHNKSNIVKEAAWTVSNITAGNQKQIQAVIQAGIFQQLRTVLEKGDF 380

Human   416 RTRKEAAWAITNATSGGTPEQI-----RYLVALGCIKPLCDLLTVMDSKIVQVALNGLENILRLG 475
            :.:||||||:||.|:.||||||     :|.:    :||..|||...|.:.::|...||.|:..|.
  Fly   381 KAQKEAAWAVTNTTTSGTPEQIVDLIEKYKI----LKPFIDLLDTKDPRTIKVVQTGLSNLFALA 441

Human   476 EQESKQNGIGINPYCALIEEAYGLDKIEFLQSHENQEIYQKAFDLIEHYF--GVEEDDPSIVPQV 538
            |:..     |....|.::||..||||:|.||.|||:|:|:||:.:|:.||  |.:|.:..:.||.
  Fly   442 EKLG-----GTENLCLMVEEMGGLDKLETLQQHENEEVYKKAYAIIDTYFSNGDDEAEQELAPQE 501

Human   539 DENQQQFIFQQQEAPMDGF 557
            .....:|...|.:||..|:
  Fly   502 VNGALEFNATQPKAPEGGY 520

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
KPNA5	NP_001353233.1	SRP1	56..541	CDD:227396	237/491 (48%)
		armadillo repeat	142..175	CDD:293788	16/32 (50%)
		armadillo repeat	183..219	CDD:293788	21/35 (60%)
		armadillo repeat	225..260	CDD:293788	12/34 (35%)
		armadillo repeat	277..302	CDD:293788	17/24 (71%)
		armadillo repeat	310..346	CDD:293788	19/35 (54%)
		armadillo repeat	354..386	CDD:293788	15/31 (48%)
		armadillo repeat	394..430	CDD:293788	20/35 (57%)
		armadillo repeat	437..471	CDD:293788	11/38 (29%)
Pen	NP_477041.1	SRP1	2..517	CDD:227396	252/534 (47%)
		HEAT repeat	70..102	CDD:293787	10/36 (28%)
		armadillo repeat	108..140	CDD:293788	16/32 (50%)
		armadillo repeat	148..184	CDD:293788	21/35 (60%)
		armadillo repeat	190..225	CDD:293788	12/34 (35%)
		armadillo repeat	359..396	CDD:293788	21/36 (58%)
		armadillo repeat	402..437	CDD:293788	11/38 (29%)